Secondary hemophagocytic lymphohistiocytosis linked to pathogenic microorganisms in pediatrics, pathophysiology and diagnosis: A review.

Secondary hemophagocytic lymphohistiocytosis (s-HLH) is an acute systemic inflammatory disorder caused by uncontrolled activation of the immune system which produces a cytokine storm. This disorder is caused by infections, autoimmune diseases or malignancy and is more prevalent in adults, therefore...

Full description

Autores:
Tipo de recurso:
Fecha de publicación:
2022
Institución:
Pontificia Universidad Javeriana Cali
Repositorio:
Vitela
Idioma:
spa
OAI Identifier:
oai:vitela.javerianacali.edu.co:11522/440
Acceso en línea:
https://revistas.javerianacali.edu.co/index.php/salutemscientiaspiritus/article/view/633
https://vitela.javerianacali.edu.co/handle/11522/440
Palabra clave:
Linfohistiocitosis hemofagocítica secundaria
Infección
Fisiopatología
Respuesta inmunológica
Diagnóstico
Pediatría
Secondary hemophagocytic lymphohistiocytosis
Infection
Physiopathology
Immunologic responde
Diagnosis
Pediatrics
Rights
License
Derechos de autor 2022 Salutem Scientia Spiritus
id Vitela2_87b7037c3c8aa8b1d0b29881facab5ea
oai_identifier_str oai:vitela.javerianacali.edu.co:11522/440
network_acronym_str Vitela2
network_name_str Vitela
repository_id_str
spelling Bermeo-Botero, CamilaDussán-Rodríguez, Jenniffer2022-12-232023-10-11T04:34:52Z2023-10-11T04:34:52Zhttps://revistas.javerianacali.edu.co/index.php/salutemscientiaspiritus/article/view/633https://vitela.javerianacali.edu.co/handle/11522/440Secondary hemophagocytic lymphohistiocytosis (s-HLH) is an acute systemic inflammatory disorder caused by uncontrolled activation of the immune system which produces a cytokine storm. This disorder is caused by infections, autoimmune diseases or malignancy and is more prevalent in adults, therefore it has few studies in pediatric patients. The aim of this review is to describe the pathophysiological relationship of s-HLH in pediatric patients according to infectious microorganisms and their diagnostic association. PubMed, Embase, SCOPUS and LILACS databases were used until May 2022. It was identified an association between s-HLH in pediatric patients and infection by different intracellular pathogens, whose pathophysiology produced similar clinical manifestations such as fever, pancytopenia and hepatosplenomegaly. Therefore, the presence of such findings should be considered to include s-HLH in the differential diagnosis.La linfohistiocitosis hemofagocítica secundaria (s-HLH) es un trastorno inflamatorio sistémico agudo dado por activación descontrolada del sistema inmune produciendo, a su vez, una tormenta de citoquinas. Este trastorno es causado por infecciones, enfermedades autoinmunes o malignidad y es más prevalente en población adulta, por lo que cuenta con pocos estudios en pacientes pediátricos. El objetivo de esta revisión es describir la relación fisiopatológica de la s-HLH en pacientes pediátricos según los microorganismos infecciosos y su asociación diagnóstica. Se utilizaron las bases de datos PubMed, Embase, SCOPUS y LILACS hasta mayo de 2022. Se identificó una relación entre la s-HLH en pacientes pediátricos y la infección por diferentes patógenos intracelulares, cuya fisiopatología se relacionó con manifestaciones clínicas similares como fiebre, pancitopenia y hepatoesplenomegalia, hallazgos que deben ser considerados para incluir dentro del diagnóstico diferencial a la s-HLH.application/pdfspaPontificia Universidad Javeriana Calihttps://revistas.javerianacali.edu.co/index.php/salutemscientiaspiritus/article/view/633/536Derechos de autor 2022 Salutem Scientia Spiritushttps://creativecommons.org/licenses/by-nc-nd/4.0Salutem Scientia Spiritus; Vol. 8 No. 4 (2022): Revista Salutem Scientia Spiritus; 64-76Salutem Scientia Spiritus; Vol. 8 Núm. 4 (2022): Revista Salutem Scientia Spiritus; 64-762463-1426Linfohistiocitosis hemofagocítica secundariaInfecciónFisiopatologíaRespuesta inmunológicaDiagnósticoPediatríaSecondary hemophagocytic lymphohistiocytosisInfectionPhysiopathologyImmunologic respondeDiagnosisPediatricsSecondary hemophagocytic lymphohistiocytosis linked to pathogenic microorganisms in pediatrics, pathophysiology and diagnosis: A review.Linfohistiocitosis hemofagocítica secundaria asociada a microorganismos patógenos en pediatría, fisiopatología y diagnóstico: Revisión de tema.info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRevisión de la literatura11522/440oai:vitela.javerianacali.edu.co:11522/4402024-06-25 05:12:42.242metadata.onlyhttps://vitela.javerianacali.edu.coRepositorio Vitelavitela.mail@javerianacali.edu.co
dc.title.en-US.fl_str_mv Secondary hemophagocytic lymphohistiocytosis linked to pathogenic microorganisms in pediatrics, pathophysiology and diagnosis: A review.
dc.title.es-ES.fl_str_mv Linfohistiocitosis hemofagocítica secundaria asociada a microorganismos patógenos en pediatría, fisiopatología y diagnóstico: Revisión de tema.
title Secondary hemophagocytic lymphohistiocytosis linked to pathogenic microorganisms in pediatrics, pathophysiology and diagnosis: A review.
spellingShingle Secondary hemophagocytic lymphohistiocytosis linked to pathogenic microorganisms in pediatrics, pathophysiology and diagnosis: A review.
Bermeo-Botero, Camila
Linfohistiocitosis hemofagocítica secundaria
Infección
Fisiopatología
Respuesta inmunológica
Diagnóstico
Pediatría
Secondary hemophagocytic lymphohistiocytosis
Infection
Physiopathology
Immunologic responde
Diagnosis
Pediatrics
title_short Secondary hemophagocytic lymphohistiocytosis linked to pathogenic microorganisms in pediatrics, pathophysiology and diagnosis: A review.
title_full Secondary hemophagocytic lymphohistiocytosis linked to pathogenic microorganisms in pediatrics, pathophysiology and diagnosis: A review.
title_fullStr Secondary hemophagocytic lymphohistiocytosis linked to pathogenic microorganisms in pediatrics, pathophysiology and diagnosis: A review.
title_full_unstemmed Secondary hemophagocytic lymphohistiocytosis linked to pathogenic microorganisms in pediatrics, pathophysiology and diagnosis: A review.
title_sort Secondary hemophagocytic lymphohistiocytosis linked to pathogenic microorganisms in pediatrics, pathophysiology and diagnosis: A review.
dc.creator.none.fl_str_mv Bermeo-Botero, Camila
Dussán-Rodríguez, Jenniffer
author Bermeo-Botero, Camila
author_facet Bermeo-Botero, Camila
Dussán-Rodríguez, Jenniffer
author_role author
author2 Dussán-Rodríguez, Jenniffer
author2_role author
dc.subject.es-ES.fl_str_mv Linfohistiocitosis hemofagocítica secundaria
Infección
Fisiopatología
Respuesta inmunológica
Diagnóstico
Pediatría
topic Linfohistiocitosis hemofagocítica secundaria
Infección
Fisiopatología
Respuesta inmunológica
Diagnóstico
Pediatría
Secondary hemophagocytic lymphohistiocytosis
Infection
Physiopathology
Immunologic responde
Diagnosis
Pediatrics
dc.subject.en-US.fl_str_mv Secondary hemophagocytic lymphohistiocytosis
Infection
Physiopathology
Immunologic responde
Diagnosis
Pediatrics
description Secondary hemophagocytic lymphohistiocytosis (s-HLH) is an acute systemic inflammatory disorder caused by uncontrolled activation of the immune system which produces a cytokine storm. This disorder is caused by infections, autoimmune diseases or malignancy and is more prevalent in adults, therefore it has few studies in pediatric patients. The aim of this review is to describe the pathophysiological relationship of s-HLH in pediatric patients according to infectious microorganisms and their diagnostic association. PubMed, Embase, SCOPUS and LILACS databases were used until May 2022. It was identified an association between s-HLH in pediatric patients and infection by different intracellular pathogens, whose pathophysiology produced similar clinical manifestations such as fever, pancytopenia and hepatosplenomegaly. Therefore, the presence of such findings should be considered to include s-HLH in the differential diagnosis.
publishDate 2022
dc.date.accessioned.none.fl_str_mv 2023-10-11T04:34:52Z
dc.date.available.none.fl_str_mv 2023-10-11T04:34:52Z
dc.date.none.fl_str_mv 2022-12-23
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
dc.type.es-ES.fl_str_mv Revisión de la literatura
status_str publishedVersion
dc.identifier.none.fl_str_mv https://revistas.javerianacali.edu.co/index.php/salutemscientiaspiritus/article/view/633
dc.identifier.uri.none.fl_str_mv https://vitela.javerianacali.edu.co/handle/11522/440
url https://revistas.javerianacali.edu.co/index.php/salutemscientiaspiritus/article/view/633
https://vitela.javerianacali.edu.co/handle/11522/440
dc.language.none.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv https://revistas.javerianacali.edu.co/index.php/salutemscientiaspiritus/article/view/633/536
dc.rights.es-ES.fl_str_mv Derechos de autor 2022 Salutem Scientia Spiritus
https://creativecommons.org/licenses/by-nc-nd/4.0
rights_invalid_str_mv Derechos de autor 2022 Salutem Scientia Spiritus
https://creativecommons.org/licenses/by-nc-nd/4.0
dc.format.none.fl_str_mv application/pdf
dc.publisher.es-ES.fl_str_mv Pontificia Universidad Javeriana Cali
dc.source.en-US.fl_str_mv Salutem Scientia Spiritus; Vol. 8 No. 4 (2022): Revista Salutem Scientia Spiritus; 64-76
dc.source.es-ES.fl_str_mv Salutem Scientia Spiritus; Vol. 8 Núm. 4 (2022): Revista Salutem Scientia Spiritus; 64-76
dc.source.none.fl_str_mv 2463-1426
institution Pontificia Universidad Javeriana Cali
repository.name.fl_str_mv Repositorio Vitela
repository.mail.fl_str_mv vitela.mail@javerianacali.edu.co
_version_ 1812095066104135680

Publicaciones similares