Evaluación del proceso de extracción de sustancias bioactivas de Orellana (Pleurotus Ostreatus) por maceración dinámica
Incluye figuras y tablas.
- Autores:
-
Duarte Trujillo, Astrid Stefanía
González Trujillo, Camila Alejandra
- Tipo de recurso:
- Trabajo de grado de pregrado
- Fecha de publicación:
- 2018
- Institución:
- Universidad de los Llanos
- Repositorio:
- Repositorio Digital Universidad de los LLanos
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.unillanos.edu.co:001/2939
- Acceso en línea:
- https://repositorio.unillanos.edu.co/handle/001/2939
https://repositorio.unillanos.edu.co/
- Palabra clave:
- Maceración
Extracción
Optimización
Pleurotus
Sustancias bioactivas
Maceration
Extraction
Optimization
Bioactive substances
- Rights
- openAccess
- License
- Derechos Reservados - Universidad de los Llanos, 2018
| id |
Unillanos2_cf517d2e4646ecd444929c5a6d4bec96 |
|---|---|
| oai_identifier_str |
oai:repositorio.unillanos.edu.co:001/2939 |
| network_acronym_str |
Unillanos2 |
| network_name_str |
Repositorio Digital Universidad de los LLanos |
| repository_id_str |
|
| dc.title.spa.fl_str_mv |
Evaluación del proceso de extracción de sustancias bioactivas de Orellana (Pleurotus Ostreatus) por maceración dinámica |
| title |
Evaluación del proceso de extracción de sustancias bioactivas de Orellana (Pleurotus Ostreatus) por maceración dinámica |
| spellingShingle |
Evaluación del proceso de extracción de sustancias bioactivas de Orellana (Pleurotus Ostreatus) por maceración dinámica Maceración Extracción Optimización Pleurotus Sustancias bioactivas Maceration Extraction Optimization Bioactive substances |
| title_short |
Evaluación del proceso de extracción de sustancias bioactivas de Orellana (Pleurotus Ostreatus) por maceración dinámica |
| title_full |
Evaluación del proceso de extracción de sustancias bioactivas de Orellana (Pleurotus Ostreatus) por maceración dinámica |
| title_fullStr |
Evaluación del proceso de extracción de sustancias bioactivas de Orellana (Pleurotus Ostreatus) por maceración dinámica |
| title_full_unstemmed |
Evaluación del proceso de extracción de sustancias bioactivas de Orellana (Pleurotus Ostreatus) por maceración dinámica |
| title_sort |
Evaluación del proceso de extracción de sustancias bioactivas de Orellana (Pleurotus Ostreatus) por maceración dinámica |
| dc.creator.fl_str_mv |
Duarte Trujillo, Astrid Stefanía González Trujillo, Camila Alejandra |
| dc.contributor.advisor.none.fl_str_mv |
Jiménez Forero, Javier Pineda Insuasti, Julio Amilcar |
| dc.contributor.author.none.fl_str_mv |
Duarte Trujillo, Astrid Stefanía González Trujillo, Camila Alejandra |
| dc.subject.proposal.spa.fl_str_mv |
Maceración Extracción Optimización Pleurotus Sustancias bioactivas |
| topic |
Maceración Extracción Optimización Pleurotus Sustancias bioactivas Maceration Extraction Optimization Bioactive substances |
| dc.subject.proposal.eng.fl_str_mv |
Maceration Extraction Optimization Bioactive substances |
| description |
Incluye figuras y tablas. |
| publishDate |
2018 |
| dc.date.issued.none.fl_str_mv |
2018 |
| dc.date.accessioned.none.fl_str_mv |
2023-07-14T14:54:35Z |
| dc.date.available.none.fl_str_mv |
2023-07-14T14:54:35Z |
| dc.type.spa.fl_str_mv |
Trabajo de grado - Pregrado |
| dc.type.driver.spa.fl_str_mv |
info:eu-repo/semantics/bachelorThesis |
| dc.type.version.spa.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_7a1f |
| dc.type.content.spa.fl_str_mv |
Text |
| dc.type.coarversion.spa.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| format |
http://purl.org/coar/resource_type/c_7a1f |
| status_str |
publishedVersion |
| dc.identifier.citation.spa.fl_str_mv |
Duarte Trujillo, Astrid S., & González Trujillo, Camila A. (2018). Evaluación del proceso de extracción de sustancias bioactivas de Orellana (Pleurotus Ostreatus) por maceración dinámica [Trabajo de grado, Universidad de los Llanos]. Repositorio digital Universidad de los Llanos. |
| dc.identifier.uri.none.fl_str_mv |
https://repositorio.unillanos.edu.co/handle/001/2939 |
| dc.identifier.instname.spa.fl_str_mv |
Universidad de los Llanos |
| dc.identifier.reponame.spa.fl_str_mv |
Repositorio digital Universidad de los Llanos |
| dc.identifier.repourl.spa.fl_str_mv |
https://repositorio.unillanos.edu.co/ |
| identifier_str_mv |
Duarte Trujillo, Astrid S., & González Trujillo, Camila A. (2018). Evaluación del proceso de extracción de sustancias bioactivas de Orellana (Pleurotus Ostreatus) por maceración dinámica [Trabajo de grado, Universidad de los Llanos]. Repositorio digital Universidad de los Llanos. Universidad de los Llanos Repositorio digital Universidad de los Llanos |
| url |
https://repositorio.unillanos.edu.co/handle/001/2939 https://repositorio.unillanos.edu.co/ |
| dc.language.iso.spa.fl_str_mv |
spa |
| language |
spa |
| dc.relation.references.spa.fl_str_mv |
ACEVEDO, Adolfo y LINARES, Martha. El enfoque y rol del ingeniero industrial para la gestión y decisión en el mundo de las organizaciones. En: Industrial data. 2012. Vol. 15, no. 1, p. 13. Disponible en: http://www.redalyc.org/pdf/816/81624969002.pdf AGRICULTURAL MARKETING RESOURCE CENTER (AMRC). Mushrooms profile. 2014. Recuperado a partir de http://www.agmrc.org/commodities-products/specialtycrops/mushrooms-profile/ ALAM, Nuhu et al. Antioxidant Activities and Tyrosinase Inhibitory Effects of Different Extracts from Pleurotus ostreatus Fruiting Bodies. En: Mycobiology. 2010, vol. 38, no. 4, p. 295-301. Disponible en: https://doi.org/10.4489/MYCO.2010.38.4.295 ALBERTS, J. F., et al. Degradation of aflatoxin B1 by fungal laccase enzymes. En: International Journal of Food Microbiology. 2009, vol. 135, no. 1, p. 47–52. Disponible en: https://doi.org/10.1016/j.ijfoodmicro.2009.07.022 ALBUQUERQUE, Bianca R, et al. Catechin-based extract optimization obtained from Arbutus unedo L. fruits using maceration/microwave/ultrasound extraction techniques. En: Industrial Crops and Products. 2017, Vol. 95, p. 404–415. Disponible en: https://doi.org/10.1016/j.indcrop.2016.10.050 AMIRULLAH, Nur Amalina; ZAINAL ABIDIN, Nurhayati y ABDULLAH, Noorlidah. The potential applications of mushrooms against some facets of atherosclerosis: A review. En: Food Research International. 2018, vol. 105, p. 517–536. Disponible en: https://doi.org/10.1016/j.foodres.2017.11.023 ANSCOMBE, Jonathan, et al. Nutraceuticals: The front line of the battle for consumer health [en línea]. 2014. Disponible en: https://www.atkearney.com ARGENTINA. COMISIÓN PERMANENTE DE LA FARMACOPEA ARGENTINA. Farmacopea Argentina. 7 ed. Buenos Aires: ANMAT, 1996. 2745 p. ISBN 9567419175 Disponible en: http://www.anmat.gov.ar/webanmat/fna/pfds/Farmacopea_Argentina_2013_Ed.7.pdf ASSOCIATION OF OFFICIAL ANALYTICAL CHEMISTS [AOAC]. Official methods of analysis of the Association of Official Analytical Chemists. 15th ed. Washington, DC: AOAC; 1990. ÁVILA, Ramona, et al. Contenido de azúcares totales, reductores y no reductores en Agave cocui Trelease. En: Multiciencias. 2012, vol. 12, no. 2, p. 129–135. Disponible en: https://doi.org/10.5897/AJB11.3143 AZMIR, J., et al. Techniques for extraction of bioactive compounds from plant materials: A review. En: Journal of Food Engineering. 2013, vol. 117, no. 4, p. 426–436. Disponible en: https://doi.org/10.1016/j.jfoodeng.2013.01.014 BAGGIO, Cristiane Hatsuko, et al. Antinociception of β-D-glucan from Pleurotus pulmonarius is possibly related to protein kinase C inhibition. En: International journal of biological macromolecules. 2012, vol. 50, no. 3, p. 872–877. Disponible en: https://doi.org/10.1016/j.ijbiomac.2011.10.023 BANO, Zakia y RAJARATHNAM, S. Pleurotus mushrooms. Part II, nutritional value, postharvest physiology, preservation and role as human food. En: CRC Critical Food Science and Nutrition. 1988, vol. 27, no. 2, p. 87-158. Disponible en: http://dx.doi.org/10.1080/10408398809527480 BERGENDIOVA, Katarina; TIBENSKA, Elena y MAJTAN, Jurak. Pleuran (β-glucan from Pleurotus ostreatus) supplementation, cellular immune response and respiratory tract infections in athletes. En: European Journal of Applied Physiology. 2011, vol. 111, no. 9, p. 2033–2040. Disponible en: https://doi.org/10.1007/s00421-011-1837-z BERNAL RODRÍGUEZ, Carlos Alfonso. Contribución al estudio farmacotécnico del extracto estandarizado de frutos de Physalis peruviana L. con miras a la obtención de un producto fitoterapéutico. Tesis de Magíster en Ciencias Farmacéuticas. Bogotá D.C.: Universidad Nacional de Colombia. Facultad de farmacia, 2012. p. 5. Disponible en: http://www.bdigital.unal.edu.co/9016/1/192546.2012.pdf BERNHOFT, Aksel. Bioactive Compounds in Plants: Benefits and Risks for Man and Animals. En: FORLAG, Novus. Proceedings from a Symposium Held in Norwegian Academy of Science and Letters. 13 - 14 November, 2008. Oslo: Det Norske Videnskaps-Akademi. 2010, p. 11–17. ISBN 978-82-7099-583-7. BHATTACHARYA, M.; SRIVASTAV, P. P. y MISHRA, H. N. Optimization of process variables for supercritical fluid extraction of ergothioneine and polyphenols from Pleurotus ostreatus and correlation to free-radical scavenging activity. En: The Journal of Supercritical Fluids. 2014, vol. 95, p. 51-59. Disponible en: https://doi.org/10.1016/j.supflu.2014.07.031 BONATTI, Mariane, et al. Evaluation of Pleurotus ostreatus and Pleurotus sajor-caju nutritional characteristics when cultivated in different lignocellulosic wastes. En: Food Chemistry. 2004, vol. 88, no. 3, p. 425–428. Disponible en: https://doi.org/10.1016/j.foodchem.2004.01.050 BRADFORD, Marion M. A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding. En: Analytical Biochemistry. 1976, vol. 72, p. 248–254. Disponible en: http://hoffman.cm.utexas.edu/courses/bradford_assay.pdf BRAVO, Karent E., et al. Desarrollo de un método para la extracción de polifenol oxidasa de uchuva (Physalis peruviana l.) y aislamiento por sistemas bifásicos acuosos. En: Vitae, vol. 18, no. 2, p. 124–132. Disponible en http://www.scielo.org.co/pdf/vitae/v18n2/v18n2a03.pdf BRECHTEL, Rolf; WÄTZIG, Hermann y RÜDIGER, Harold. The lectin from the mushroom Pleurotus ostreatus: A phosphatase-activating protein that is closely associated with an α-galactosidase activity: A part of this paper has been presented as a preliminary report at the 17th interlec. Meeting 1997 in Würzburg, Germany. En: Plant Science. 2001, vol. 160, no. 5, p. 1025–1033. Disponible en: https://doi.org/10.1016/S01689452(01)00349-1 CANADÁ. AGRICULTURE AND AGRI-FOOD. Consumer trends: functional foods. Market Analysis Report. El Ministerio: December, 2009. p. 4. Disponible en: https://www.gov.mb.ca/agriculture/market-prices-and-statistics/food-and-value-addedagriculture-statistics/pubs/consumer_trends_functional_foods_en.pdf CARDONA URREA, Luis Fernando. Anotaciones acerca de la bromatología y el cultivo del hongo comestible Pleurotus ostreatus. En: Crónica Forestal y del Medio Ambiente. 2001, vol. 16, p. 99–119. CHANG, Shu-Ting y MILES, Philip G. Mushrooms: Cultivation, nutritional value, medicinal effect, and environmental impact. 2. ed. Florida: CRC Press, 2004. p. 8. ISBN 0-84931043-1. CHAUHAN, Baby, et al. Current concepts and prospects of herbal nutraceutical: A review. En: J Adv Pharm Technol Res. 2013, vol. 4, no. 1, p. 4–8. Disponible en: https://doi.org/10.4103/2231-4040.107494 CHEN, Lei, et al. Cell wall structure of mushroom sclerotium (Pleurotus tuber regium): Part 1. Fractionation and characterization of soluble cell wall polysaccharides. En: Food Hydrocolloids. 2014, vol. 36, p. 189–195. Disponible en: https://doi.org/10.1016/j.foodhyd.2013.09.023 CHEN, Shin Yu, et al. Contents of lovastatin, γ-aminobutyric acid and ergothioneine in mushroom fruiting bodies and mycelia. En: LWT - Food Science and Technology. 2012, vol. 47, no. 2, p. 274–278. Disponible en: https://doi.org/10.1016/j.lwt.2012.01.019 CHITIVA JARAMILLO, Adriana, et al. Contribución al estudio de microhongos filamentosos en los ecosistemas Páramo de Guasca y El Tablazo. Estudio preliminar de mohos de páramos colombianos. Bogotá D.C.: Universidad Pontificia Bolivariana, 2007. p. 3. Disponible en: http://www.javeriana.edu.co/gifuj/hongos_%20ecosistemas_%20paramo.pdf CHILDS, Nancy M. Obesity policy: Opportunities for Funcional Food Market Growth. En: Handbook of Nutraceuticals and Functional Foods. 2 ed. Boca Raton, Florida: Robert E. C. Wildman, 2007. p. 1–22. ISBN: 978-1-4200-0618-6. Disponible en: https://doi.org/10.1201/9781420006186 CHOBOT, Vladimir, et al. Ergosta-4,6,8,22-tetraen-3-one from the edible fungus, Pleurotus ostreatus (oyster fungus). En: Nutrition. 1997, vol. 45, no. 8, p. 1669–1671. Disponible en: https://doi.org/10.1016/S0031-9422(97)00249-5 CHOI, Jae Ho et al. Topical application of Pleurotus eryngii extracts inhibits 2,4dinitrochlorobenzene-induced atopic dermatitis in NC/Nga mice by the regulation of Th1/Th2 balance. En: Food and Chemical Toxicology. 2013, vol. 53, p. 38–45. Disponible en: https://doi.org/10.1016/j.fct.2012.11.025 CHOU, Youn-Min; POLANSKY, Alan M y MASON, Robert L. Transforming non-normal data to normality in statistical process control. En: Journal of Quality Technology. 1998, vol. 30, no. 2, p. 133–141. Disponible en: https://goo.gl/zzmnWR CILERDZIC, Jasmina, et al. Antioxidant and Antifungal Potential of Pleurotus ostreatus and Agrocybe cylindracea Basidiocarps and Mycelia. En: Current Pharmaceutical Biotechnology. 2015, vol. 17, no. 2, p. 179–186. Disponible en: http://www.ingentaconnect.com/content/ben/cpb/2015/00000016/00000002/art00010 COLOMBIA. DEPARTAMENTO NACIONAL DE PLANEACIÓN (DNP). Bases del Plan Nacional de Desarrollo 2014-2018. Bogotá D.C.: El departamento, 2014. 783 p. Disponible en: https://colaboracion.dnp.gov.co/cdt/prensa/bases%20plan%20nacional%20de%20des arrollo%202014-2018.pdf COLOMBIA. MINISTERIO DE LA PROTECCIÓN SOCIAL. Decreto Número 2266 (14, julio, 2004). Por el cual se reglamentan los regímenes de registros sanitarios, y de vigilancia y control sanitario y publicidad de los productos fitoterapéuticos. Bogotá D.C.: El Ministerio, 2004. p. 3. Disponible en: http://biblioteca.saludcapital.gov.co/img_upload/03d591f205ab80e521292987c313699 c/decreto_2266_2004.pdf CONRAD, Fritz y RÜDIGER, Harold. The lectin from Pleurotus ostreatus: Purification, characterization and interaction with a phosphatase. En: Phytochemistry. 1994, vol. 36, no. 2, p. 277–283. Disponible en: https://doi.org/10.1016/S0031-9422(00)97061-4 ĆUJIĆ, Nada, et al. Optimization of polyphenols extraction from dried chokeberry using maceration as traditional technique. En: Food Chemistry. 2016, vol. 194, p. 135–142. Disponible en: https://doi.org/10.1016/j.foodchem.2015.08.008 DALONSO, Nicole, et al. Characterization and antineoplasic effect of extracts obtained from Pleurotus sajor-caju fruiting bodies. En: Applied Biochemistry and Biotechnology. 2010, vol. 160, no. 8, p. 2265 – 2274. Disponible en: https://doi.org/10.1007/s12010009-8678-9 DEEPALAKSHMI, Krishnamoorthy y MIRUNALINI, Sankaran. Efficacy of Pleurotus ostreatus (Jacq. Ex Fr.) P. kumm. on 7,12-dimethylbenz(a)anthracene induced mammary carcinogenesis in female Sprague-Dawley rats. En: New Horizons in Translational Medicine. 2016, vol. 3, no. 2, p. 73–82. Disponible en: https://doi.org/10.1016/j.nhtm.2016.06.002 DEVI, K. Sanjana P, et al. Characterization and lectin microarray of an immunomodulatory heteroglucan from Pleurotus ostreatus mycelia. En: Carbohydrate Polymers. 2013, vol. 94, no. 2, p. 857–865. Disponible en: https://doi.org/10.1016/j.carbpol.2013.02.017 DEVI, K. Sanjana P, et al. Immune augmentation and Dalton’s Lymphoma tumor inhibition by glucans/glycans isolated from the mycelia and fruit body of Pleurotus ostreatus. En: International Immunopharmacology. 2015, vol. 25, no. 1, p. 207–217. Disponible en: https://doi.org/10.1016/j.intimp.2015.01.026 DIEM, Konrad. Tablas Cientificas: Documenta Geigy. Basilea: J.R. Geigy S. A., 1965. p. 320-321 DUBOIS, Michel, et al. Colorimetric method for determination of sugars and related substances. En: Analytical Chemistry. 1956, vol. 28, no. 3, p. 350–356. Disponible en: https://doi.org/10.1021/ac60111a017 ELISASHVILI, Vladimir, et al. Use of Pleurotus dryinus for lignocellulolytic enzymes production in submerged fermentation of mandarin peels and tree leaves. En: Enzyme and Microbial Technology. 2006, vol. 38, no.7, p. 998–1004. Disponible en: https://doi.org/10.1016/j.enzmictec.2005.08.033 EL-FAKHARANY, Esmail M., et al. Oyster Mushroom Laccase Inhibits Hepatitis C Virus Entry into Periph- eral Blood Cells and Hepatoma Cells. En: Protein & Peptide Letters. 2010, vol. 17, no. 1, p. 1031–1039. Disponible en: https://doi.org/10.2174/092986610791498948 FACCHINI, Jean Mary, et al. Antitumor activity of Pleurotus ostreatus polysaccharide fractions on Ehrlich tumor and Sarcoma 180. En: International Journal of Biological Macromolecules. 2014, vol. 68, p. 72–77. Disponible en: https://doi.org/10.1016/J.IJBIOMAC.2014.04.033 FINIMUNDY, Tiane C., et al. Aqueous extracts of Lentinula edodes and Pleurotus sajorcaju exhibit high antioxidant capability and promising in vitro antitumor activity. En: Nutr. Res. 2013, vol. 33, p. 76–84. Disponible en: https://doi.org/10.1016/j.nutres.2012.11.005 FLORES, Maria Victoria, VOGET, C. y ERTOLA, J. Permeabilization of yeast cells (Kluyveromyces lactis) with organic solvents. En: Enzyme and Microbial Technology. 1994, vol. 16, no. 4, p. 340–346. Disponible en: https://doi.org/10.1016/01410229(94)90177-5 FONTES VIEIRA, Patrícia A. et al. Antioxidant activities, total phenolics and metal contents in Pleurotus ostreatus mushrooms enriched with iron, zinc or lithium. En: LWT - Food Science and Technology. 2013, vol. 54, no. 2, p. 421–425. Disponible en: https://doi.org/10.1016/j.lwt.2013.06.016 FOOD AND AGRICULTURE ORGANIZATION OF THE UNITED NATIONS (FAO). Statistics. [en línea]. Disponible en: http://faostat3.fao.org/home/E AO, Wenjuan, et al. Mushroom lectin enhanced immunogenicity of HBV DNA vaccine in C57BL/6 and HBsAg-transgenic mice. En: Vaccine. 2013, vol. 31, no. 18, p. 2273– 2280. Disponible en: https://doi.org/10.1016/j.vaccine.2013.02.062 GASECKA, Monika, et al. The effect of selenium on phenolics and flavonoids in selected edible white rot fungi. En: LWT - Food Science and Technology. 2015, vol. 63, no, 1, p. 726–731. Disponible en: https://doi.org/10.1016/j.lwt.2015.03.046 GIL RAMÍREZ, Alicia, et al. Mushrooms do not contain flavonoids. En: Journal of Functional Foods. 2016, vol. 25, p. 1–13. Disponible en: https://doi.org/10.1016/j.jff.2016.05.005 GIL RAMÍREZ, Alicia, et al. Screening of edible mushrooms and extraction by pressurized water (PWE) of 3-hydroxy-3-methyl-glutaryl CoA reductase inhibitors. En: Journal of Functional Foods. 2012, vol. 5, p. 244-250. Disponible en: https://doi.org/10.1016/j.jff.2012.10.013 GOMES CORRÊA, Rúbia Carvalho, et al. Biotechnological, nutritional and therapeutic uses of Pleurotus spp. (Oyster mushroom) related with its chemical composition: A review on the past decade findings. En: Trends in Food Science & Technology. 2016, vol. 50, p. 103–117. Disponible en: https://doi.org/10.1016/j.tifs.2016.01.012 GRIFFIN, Roger D. Principles of Hazardous Materials Management. 2. ed. Boca Raton: CRC Press, 2009. P. 216.ISBN 9781420089714. GULLÓN, Beatriz, et al. Rutin: A review on extraction, identification and purification methods, biological activities and approaches to enhance its bioavailability. En: Trends in Food Science & Technology. 2017, no. 67. p. 220-235. Disponible en: https://doi.org/10.1016/j.tifs.2017.07.008 GUNAWARDENA, Dhanushka, et al. Anti-inflammatory effects of five commercially available mushroom species determined in lipopolysaccharide and interferon-γ activated murine macrophages. En: Food Chemistry. 2014, vol. 148, p. 92–96. Disponible en: https://doi.org/10.1016/j.foodchem.2013.10.015 HAPSARI, Riani; ELYA, Berna y AMIN, Juheini. Formulation and evaluation of antioxidant and tyrosinase inhibitory effect from gel containing the 70% ethanolic Pleurotus ostreatus extract. En: Int. J. Med. Arom. Plants. 2012, vol. 2, no. 1, p. 135–140. Disponible en: https://goo.gl/b3nSXE HASHIM, Shima N. N. S., et al. Recovery of ergosterol from the medicinal mushroom, Ganoderma tsugae var. Janniae, with a molecularly imprinted polymer derived from a cleavable monomer-template composite. En: Journal of Chromatography A. 2016, vol. 1468, p. 1–9. Disponible en: https://doi.org/10.1016/j.chroma.2016.09.004 HATHCOCK, John N., & SHAO, Andrew. Risk assessment for coenzyme Q10 (Ubiquinone). En: Regulatory Toxicology and Pharmacology. 2006, vol. 45, no. 3, p. 282–288. Disponible en: https://doi.org/10.1016/j.yrtph.2006.05.006 HU, Shu Hui et al. Antihyperlipidemic and Antioxidant Effects of Extracts from Pleurotus citrinopileatus. En: Journal of Agricultural and Food Chemistry. 2006, vol. 54, no. 6, p. 2103–2110. Disponible en: https://doi.org/10.1021/jf052890d HUANG, Shih Jeng; LIN, Chun Ping y TSAI, Shu Yao. Vitamin D2 content and antioxidant properties of fruit body and mycelia of edible mushrooms by UV-B irradiation. En: Journal of Food Composition and Analysis. 2015, vol. 42, p. 38–45. Disponible en: https://doi.org/10.1016/j.jfca.2015.02.005 KEWUCHI, J. C., et al. Moderation of hematological and plasma biochemical indices of sub-chronic salt-loaded rats by aqueous extract of the sclerotia of Pleurotus tuberregium (Fr) Sing’s: Implications for the reduction of cardiovascular risk. En: Journal of Ethnopharmacology. 2013, vol. 150, no. 2, p. 466–476. Disponible en: https://doi.org/10.1016/j.jep.2013.09.002 INSTITUTO COLOMBIANO DE NORMALIZACIÓN Y CERTIFICACIÓN. Sistemas de Gestión de la Calidad: fundamentos y vocabulario. NTC-ISO 9000. Bogotá D.C.: El instituto, 2005. p. 10. Disponible en: https://tienda.icontec.org/wp- content/uploads/pdfs/NTC-ISO9000-2015.pdf WALOKUN, Bamidele, et al. Comparative phytochemical evaluation, antimicrobial antioxidant properties of Pleurotus ostreatus. African Journal of Biotechnology. 2007, vol 6, no. 15, p. 1732-1739. Disponible en: http://www.ajol.info/index.php/ajblarticle/download/57767/46134 JAYAKUMAR, T., et al. Pleurotus ostreatus, an oyster mushroom, decreases the oxidative stress induced by carbon tetrachloride in rat kidneys, heart and brain. En: ChemicoBiological Interactions. 2008, vol. 176, no. 2–3, p. 108–120. Disponible en: https://doi.org/10.1016/j.cbi.2008.08.006 JESENAK, Milos, et al. Anti-allergic effect of Pleuran (β-glucan from Pleurotus ostreatus) in children with recurrent respiratory tract infections. En: Phytotherapy Research. 2014, vol. 28, no. 3, p. 471–474. Disponible en: https://doi.org/10.1002/ptr.5020 JESENAK, Milos, et al. Immunomodulatory effect of Pleuran (β-glucan from Pleurotus ostreatus) in children with recurrent respiratory tract infections. En: International Immunopharmacology. 2013, vol. 15, no. 2, p. 395-399. Disponible en: https://doi.org/10.1016/j.intimp.2012.11.020 JIAO, Fengping, et al. Processing optimization and anti-oxidative activity of enzymatic extractable polysaccharides from Pleurotus djamor. En: International Journal of Biological Macromolecules. 2017, vol. 98, p. 469–478. Disponible en: https://doi.org/10.1016/J.IJBIOMAC.2017.01.126 JOVANOVIĆ, Aleksandra A., et al. Optimization of the extraction process of polyphenols from Thymus serpyllum L. herb using maceration, heat- and ultrasound-assisted techniques. En: Separation and Purification Technology. 2017, vol. 179, p. 369–380. Disponible en: https://doi.org/10.1016/j.seppur.2017.01.055 KAKON, A. J.; CHOUDHURY, Md Bazlul Karim y SAHA, Shusmita. Mushroom in an ideal food supplement. En: Journal of Dhaka National Medical College & Hospital. 2012, vol. 18, p. 58-62. Disponible en: http://dx.doi.org/10.3329/jdnmch.v18i1.12243 KALARAS, Michael D., et al. Mushrooms: A rich source of the antioxidants ergothioneine and glutathione. En: Food Chemistry. 2017, vol. 233, p. 429–433. Disponible en: https://doi.org/10.1016/j.foodchem.2017.04.109 KAWAGISHI, Hirokazu, et al. A lectin from an edible mushroom Pleurotus ostreatus as a food intake-suppressing substance. En: Biochimica et Biophysica Acta - General Subjects. 2000, vol. 1474, no. 3, p. 299–308. Disponible en: https://doi.org/10.1016/S0304-4165(00)00027-1 KHAN, Asma Ashraf, et al. Structural, rheological, antioxidant, and functional properties of β–glucan extracted from edible mushrooms Agaricus bisporus, Pleurotus ostreatus and Coprinus attrimentarius. En: Bioactive Carbohydrates and Dietary Fibre. 2017, vol. 11, p. 67–74. Disponible en: https://doi.org/10.1016/J.BCDF.2017.07.006 KHARB, Simmi y SINGH, Veena. Nutriceuticals in health and disease prevention. En: Indian Journal of Chemical Biochemistry. 2004, vol. 59, no. 1, p. 50-53. Disponible en: https://doi.org/10.1007/BF02872389 KHATUN, Selima, et al. Nutritional qualities and antioxidant activity of three edible oyster mushrooms (Pleurotus spp.). En: NJAS - Wageningen J Life Sci. 2015, vol. 72, p. 1–5. Disponible en: https://doi.org/10.1016/j.njas.2012.03.003 KIM, Gyuri, et al. Statin use and the risk of hepatocellular carcinoma in patients at high risk: a nationwide nested case-control study. En: Journal of Hepatology. 2017. In press. Disponible en: https://doi.org/10.1016/j.jhep.2017.10.018 KNOP, Doriv; YARDEN, Oded y HADAR, Yitzhak. The ligninolytic peroxidases in the genus Pleurotus: divergence in activities, expression and potencial applications. En: Applied Microbiology and Biotechnology. 2015, vol. 99, p. 1025-1038. Disponible en: https://doi.org/10.1007/s00253-014-6256-8 KO, Yuan-Tih y LIN, Yu-Ling. 1,3-D-Glucan Quantification by a Fluorescence Microassay and Analysis of Its Distribution in Foods. En: Journal of agricultural and food chemistry, 2004, vol. 13, p. 3313–3318. Disponible en: https://doi.org/10.1021/jf0354085 KOENIG, Steven, et al. Quantitative assay of β-(1,3)–β-(1,6)–glucans from fermentation broth using aniline blue. En: Carbohydrate Polymers. 2017, vol. 174, p. 57–64. Disponible en: https://doi.org/10.1016/j.carbpol.2017.06.047 KOMURA, Dirce L., et al. Water-soluble polysaccharides from Pleurotus ostreatus var. florida mycelial biomass. En: International Journal of Biological Macromolecules. 2014, vol. 70, p. 354–359. Disponible en: https://doi.org/10.1016/j.ijbiomac.2014.06.007 KONG, Fanli. Anti-tumor and macrophage activation induced by alkali-extracted polysaccharide from Pleurotus ostreatus. En: International Journal of Biological Macromolecules. 2014, vol. 69, p. 561–566. Disponible en: https://doi.org/10.1016/j.ijbiomac.2014.05.045 KRINGS, Ulrich y BERGER, Ralf G. Dynamics of sterols and fatty acids during UV-B treatment of oyster mushroom. En: Food Chemistry. 2014, vol. 149, p. 10–14. Disponible en: https://doi.org/10.1016/j.foodchem.2013.10.064 LAVI, Iris, et al. An aqueous polysaccharide extract from the edible mushroom Pleurotus ostreatus induces anti-proliferative and pro-apoptotic effects on HT-29 colon cancer cells. En: Cancer Letters. 2006, vol. 244, no. 1, p. 61–70. Disponible en: https://doi.org/10.1016/j.canlet.2005.12.007 LEÓN, Orfelio G. y MONTERO, Ignacio. Cómo explicar el concepto de interacción sin estadística: análisis gráfico de todos los casos posibles en un diseño 2 x 2. En: Psicothema. 2001, vol. 13, no. 1, p. 159-165. Disponible en: http://www.redalyc.org/html/727/72713123/ LIANG, Zeng-Chin, et al. Utilization of grass plants for cultivation of Pleurotus citrinopileatus. En: International Biodeterioration & Biodegradation. 2009, vol. 63, no. 4, p. 509–514. Disponible en: https://doi.org/10.1016/j.ibiod.2008.12.006 LIMA, Marcos Dos Santos, et al. Phenolic compounds, organic acids and antioxidant activity of grape juices produced in industrial scale by different processes of maceration. En: Food Chemistry. 2015, vol. 188, p. 384–392. Disponible en: https://doi.org/10.1016/j.foodchem.2015.04.014 LI, Jinyao, et al. Pleurotus ferulae water extract enhances the maturation and function of murine bone marrow-derived dendritic cells through TLR4 signaling pathway. En: Vaccine. 2015, vol. 33, p. 1923–33. Disponible en: https://doi.org/10.1016/j.vaccine.2015.02.063 LI, Siqian y SHAH, Nagendra P. Effects of Pleurotus eryngii polysaccharides on bacterial growth, texture properties, proteolytic capacity, and angiotensin-I-converting enzymeinhibitory activities of fermented milk. En: J Dairy Sci. 2015, vol. 98, p. 2949 – 2961. Disponible en: https://doi.org/10.3168/jds.2014-9116 LIU, Xiaonan, et al. Extraction and antioxidant activities of intracellular polysaccharide from Pleurotus sp. mycelium. En: International Journal of Biological Macromolecules. 2010, vol. 47, no. 2, p. 116–119. Disponible en: https://doi.org/10.1016/J.IJBIOMAC.2010.05.012 LIU, Xinkui et al. Structure characterization and antitumor activity of a polysaccharide from the alkaline extract of king oyster mushroom. En: Carbohydrate Polymers. 2015, vol. 118, p. 101–106. Disponible en: https://doi.org/10.1016/j.carbpol.2014.10.058 LLAURADÓ, Gabriel, et al. In-vitro antimicrobial activity and complement/macrophage stimulating effects of a hot-water extract from mycelium of the oyster mushroom Pleurotus sp. En: Innovative Food Science & Emerging Technologies. 2015, vol. 30, p. 177–183. Disponible en: https://doi.org/10.1016/j.ifset.2015.05.002 LLAURADÓ, Gabriel, et al. Oral administration of an aqueous extract from the oyster mushroom Pleurotus ostreatus enhances the immunonutritional recovery of malnourished mice. En: Biomedicine and Pharmacotherapy. 2016, vol. 83, p. 1456– 1463. Disponible en: https://doi.org/10.1016/j.biopha.2016.08.067 MACÁKOVÁ, Kateřina, et al. Tannins and their Influence on Health. En: UR-RAHMAN, Atta y CHOUDHARY, Muhammad Iqbal (Eds.), Recent Advances in Medicinal Chemistry Recent Advances in Medicinal Chemistry. Amsterdam: Bentham Science Publishers, 2014. p. 159–208. ISBN: 9780128039618 MACHADO ROCHA, Leandro. Extracción de materias primas vegetales. En: PINZÓN, Roberto. Fundamentos de Tecnología de Productos Fitoterapéuticos. Bogotá D.C.: Área de Ciencia y Tecnología del Convenio Andrés Bello & Red Iberoamericana de Productos Fitofarmacéuticos (RIPROFITO) del subprograma X del CYTED, 2000. p. 61-70. ISBN 9586980014. MA, Gaoxing, et al. Purification, characterization and antitumor activity of polysaccharides from Pleurotus eryngii residue. En: Carbohydr Polym. 2014, vol. 114, p. 297–305. Disponible en: https://doi.org/10.1016/j.carbpol.2014.07.069 MAITY, Kousik, et al. Structural characterization and study of immunoenhancing and antioxidant property of a novel polysaccharide isolated from the aqueous extract of a somatic hybrid mushroom of Pleurotus florida and Calocybe indica variety APK2. En: International Journal of Biological Macromolecules. 2011, Vol. 48, no. 2, p. 304–310. Disponible en: https://doi.org/10.1016/j.ijbiomac.2010.12.003 MANZI, Pamela y PIZZOFERRATO, Laura. Beta-glucans in edible mushrooms. En: Food Chemistry. 2000, vol. 68, no. 3, p. 315–318. Disponible en: https://doi.org/10.1016/S0308-8146(99)00197-1 MARTÍNEZ-RINCÓN, Leydi Johana. Colombia y Brasil, complejidad logística: ¿verdad o mito? EAFIT, 2016. p. 1. Disponible en: http://hdl.handle.net/10784/11244 MARTÍNEZ-SÁNCHEZ, Angel y PÉREZ-PÉREZ, Manuela. R&D project efficiency management in the Spanish industry. En: International Journal of Project Management. 2002. vol. 20, no. 7, p. 545. Disponible en: https://doi.org/10.1016/S0263-7863(01)00024-2 MASSADEH, Muhannad I.; FRAIJA, Abeer y FANDIB, Khalid. Effect of Carbon Sources on The Extracellular Lignocellulolytic Enzymetic System of Pleurotus Sajor-Caju. En: Jordan journal of Biological Science. 2010, vol. 3, no.2, p. 51–54. Disponible en: https://eis.hu.edu.jo/deanshipfiles/pub105086141.pdf MATTILA, Pirjo, et al. Basic composition and amino acid contents of mushrooms cultivated in Finland. En: Journal of Agricultural and Food Chemistry. 2002, vol. 50, no. 22, p. 6419–6422. Disponible en: https://doi.org/10.1021/jf020608m MAU, Jeng Leun, et al. Nonvolatile taste components of ear mushrooms. En: Journal of Agricultura and food chemistry. 1998, vol. 46, no.11 p. 4583 – 4586. Disponible en: https://10.1021/jf9805606 McCLEAR, Barry y GLENNIE-HOLMES, Malcolm. Enzymatic quantification of (1-3)(1-4)beta-D-Glucan in barley and malt. En: Journal of the Institute of Brewing. 1985, vol. 9, p. 285–295. Disponible en: https://doi.org/10.1002/j.2050-0416.1985.tb04345.x MILLER, Gail Lorenz. Use of Dinitrosalicylic Acid Reagent for Determination of Reducing Sugar. En: Analytical Chemistry. 1959, vol. 31, no. 3, p. 426–428. ISSN 0003-2700. Disponible en: https://doi.org/10.1021/ac60147a030 MITRA, Amal K. y RODRÍGUEZ FERNANDEZ, Gisella. Latin America and the Caribbean: assessment of the advances in public health for the achievement of the Millennium Development Goals. En: Int J Environ Res Public Health. 2010, vol. 7, no. 5, p. 2238– 2255. Disponible en: https://doi.org/10.3390/ijerph7052238 MITRA, Payel; KHATUA, Somanjana y ACHARYA, Krishnendu. Free radical scavenging and nos activation properties of water soluble crude polysaccharide from Pleurotus ostreatus. En: Asian Journal of Pharmaceutical and Clinical Research. 2013, vol. 6, no. 3, p. 67–70. Disponible en: http://www.ajpcr.com/Vol6Issue3/53.pdf MIZUNO, Masashi, et al. Contents of AntiTumor Polysaccharides in Certain Mushroomsand Their Immunomodulating Activities. En: Food Science and Technology Research2001, vol. 7, no. 1, p. 31–34. Disponible en: https://doi.org/10.3136/fstr.7.31 MUÑOZ, Carlos. Cómo elaborar y asesorar una investigación de tesis. 2 ed. Ciudad de México: Pearson educación, 2011. 320 p. Disponible en: http://www.unamerida.com/documentos/bileidis/ElaborarTesis.pdf NASRI, Hamid, et al. New Concepts in Nutraceuticals as Alternative for Pharmaceuticals. En: Int J Prev Med. 2014, vol. 5, no. 12, p. 1487–1499. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4336979/ NATTOH, Godfrey, et al. Towards profiling differential distribution of bioactive molecules across four phenologies in Pleurotus djamor R22. En: Asian Pacific J Trop Dis. 2016, vol. 6, no. 6, p. 472–480. Disponible en: https://doi.org/10.1016/S2222-1808(16)6107x NITSCHKE, Jörg, et al. A new colorimetric method to quantify β-1,3-1,6-glucans in comparison with total β-1,3-glucans in edible mushrooms. En: Food chemistry. 2011 vol. 127, no. 2, p. 791–796. Disponible en: https://doi.org/10.1016/j.foodchem.2010.12.149 NIKIFOROVA, Svetlana V.; POZDNYAKOVA, Natalia N. y TURKOVSKAYA, Olga V. Emulsifying agent production during PAHs degradation by the white rot fungus Pleurotus Ostreatus D1. En: Current Microbiology. 2009, vol. 58, no. 6, p. 554–558. https://doi.org/10.1007/s00284-009-9367-1 NIKSIC, Miomir; KLAUS, Anita y ARGYROPOULOS, Dimitrios. Safety of foods based on mushrooms. En: PRAKASH, Vishweshwaraiah, et al. Regulating Safety of Traditional and Ethnic Foods. Waltham, Massachusetts: Academic Press, 2016. p. 423-425. ISBN 9780128006054. NNADIUKWU, Tochukwu Anthony; MONAGO, C. C. y CHUKU, L. C. Histological Effect of Combined Ethanol Extract of Moringa oleifera and Pleurotus ostreatus on the Pancreas of Alloxan-induced Diabetic Wistar Albino Rats. En: Journal of Applied Life Sciences International. 2016, vol. 5, no. 3, p. 1–8. Disponible en: https://doi.org/10.9734/JALSI/2016/26108 ORGANIZACIÓN DE LAS NACIONES UNIDAS (ONU). Objetivos de Desarrollo Sostenible. En: Cumbre Mundial sobre el Desarrollo Sostenible. Recuperado de http://www.un.org/sustainabledevelopment/es/summit/ ORGANIZACIÓN MUNDIAL DE LA SALUD (OMS). Informe mundial sobre el envejecimiento y la salud. Estados Unidos: OMS, 2015. 282 p. ISBN: 978-92-4069487 3. Disponible en: http://apps.who.int/iris/bitstream/10665/186466/1/9789240694873_spa.pdf ORTIZ MORENO, Martha Lucía. Macromicetos en Zona Rural de Villavicencio. En: Rev Orinoquia. 2010, vol. 14, no. 2, p. 125 – 132. Disponible en: http://orinoquia.unillanos.edu.co/index.php/orinoquia/article/view/68/544 PAHILA, Jade et al. Effects of ergothioneine-rich mushroom extracts on lipid oxidation and discoloration in salmon muscle stored at low temperatures. En: Food Chemistry. 2017, vol. 233, p. 273–281. Disponible en: https://doi.org/10.1016/j.foodchem.2017.04.130 PALACIOS, Irene. Novel isolation of water-soluble polysaccharides from the fruiting bodies of Pleurotus ostreatus mushrooms. En: Carbohydrate Research. 2012, vol. 358, p. 72–77. Disponible en: https://doi.org/10.1016/j.carres.2012.06.016 PALMIERI, Gianna, et al. Copper Induction of Laccase Isoenzymes in the Ligninolytic Fungus Pleurotus ostreatus. En: Applied And Environmental Microbiology. 2000, vol. 66, no 3, pp. 920–924. Disponible en: https://doi.org/10.1128/AEM.66.3.920-924.2000 PALMER, Michelle y CHAGUTURU, Rathnam. Academia–pharma partnerships for novel drug discovery: essential or nice to have? En: Expert Opinion on Drug Discovery. 2017, p. 1. Disponible en: https://doi.org/10.1080/17460441.2017.1318124 PAPASPYRIDI, Lefki-Maria, et al. Production of bioactive metabolites with pharmaceutical and nutraceutical interest by submerged fermentation of Pleurotus ostreatus in a batch stirred tank bioreactor. En: Procedia Food Science. 2011, vol. 1, no. 11, p. 1746–1752. Disponible en: https://doi.org/10.1016/j.profoo.2011.09.257 PATRA, Sukesh, et al. A heteroglycan from the mycelia of Pleurotus ostreatus: Structure determination and study of antioxidant properties. En: Carbohydrate Research. 2013, vol. 368, p. 16–21. Disponible en: https://doi.org/10.1016/j.carres.2012.12.003 PEDNEAULT, Karine, et al. Fatty acid profiles of polar and non-polar lipids of Pleurotus ostreatus and P. cornucopiae var. “citrinopileatus” grown at different temperaturas En: Mycological Research. 2007, vol. 111, no. 10, p. 1228–1234. Disponible en: https://doi.org/10.1016/j.mycres.2007.06.014 PÉREZ-MARTÍNEZ, Ana S., et al. A perspective on the use of Pleurotus for the development of convenient fungi-made oral subunit vaccines. En: Vaccine. 2015, vol. 33, no. 1, p. 25–33. Disponible en: https://doi.org/10.1016/j.vaccine.2014.10.059 PHAT, Chanvorleak; MOON, Bokyung y LEE, Chan. Evaluation of umami taste in mushroom extracts by chemical analysis, sensory evaluation, and an electronic tongue system. En: Food Chemistry. 2016, vol. 192, p. 1068–1077. Disponible en: https://doi.org/10.1016/j.foodchem.2015.07.113 PINEDA INSUASTI, Julio Almicar. Desarrollo de una tecnología para la producción a pequeña escala de la biomasa del hongo ostra (Pleurotus ostreatus). Tesis de doctorado en Ciencias Técnicas. Universidad de Camagüey Ignacio Agramonte Loynaz. Facultad de Química. Departamento de Ingeniería Química. 203 p. Disponible en: http://repositorio.educacionsuperior.gob.ec/bitstream/28000/1586/1/TSENESCYT-00704.pdf PLEMENITAŠ, Ana, et al. Steroidogenesis in the fungus Pleurotus ostreatus. En: Comparative Biochemistry and Physiology – B: Biochemistry and Molecular Biology. 1999, vol. 123, no. 2, p. 175–179. Disponible en: https://doi.org/10.1016/S03050491(99)00053-X RADZKI, Wojciech, et al. Effect of processing on the content and biological activity of polysaccharides from Pleurotus ostreatus mushroom. En: LWT - Food Science and Technology. 2016, vol. 66, p. 27–33. Disponible en: https://doi.org/10.1016/j.lwt.2015.10.016 RAMESH, CH y PATTAR, Manohar G. Antimicrobial properties, antioxidant activity and bioactive compounds from six wild edible mushrooms of western ghats of Karnataka, India. En: Pharmacognosy Res. 2010, vol. 2, p. 107–112. Disponible en: https://doi.org/10.4103/0974-8490.62953 RAMÍREZ-NIÑO, Miguel Ángel. Identificación y Cuantificación de carbohidratos totales. Guía de laboratorio de Química Agroindustrial. Villavicencio, Colombia: Universidad de Los Llanos, 2017. 4 p. RANA, Tanmoy, et al. Pleurotus florida lectin normalizes duration dependent hepatic oxidative stress responses caused by arsenic in rat. En: Experimental and Toxicologic Pathology. 2012, vol. 64, no. 7–8, p. 665–671. Disponible en: https://doi.org/10.1016/j.etp.2010.12.010 REDDY, Gorla V., et al. Utilization of banana waste for the production of lignolytic and cellulolytic enzymes by solid substrate fermentation using two Pleurotus species (P. ostreatus and P. sajor-caju). En: Process Biochemistry. 2003, vol. 38, no. 10, pp. 1457–1462. Disponible en: https://doi.org/10.1016/S0032-9592(03)00025-6 REN, Daoyuan, et al. Antioxidant and antitumor effects of polysaccharides from the fungus Pleurotus abalonus. En: Chem Biol Interact. 2015, vol. 237, p. 166–74. Disponible en: https://doi.org/10.1016/j.cbi.2015.06.017 REN, Lu, et al. Antibacterial and antioxidant activities of aqueous extracts of eight edible mushrooms. En: Bioactive Carbohydrates and Dietary Fibre. 2014, vol. 3, no. 2, p. 41–51. Disponible en: https://doi.org/10.1016/j.bcdf.2014.01.003 REN, Qilong, et al. Recent Advances in Separation of Bioactive Natural Products. En: Chinese Journal of Chemical Engineering. 2013, vol. 21, no. 9, p. 937–952. Disponible en: https://doi.org/10.1016/S1004-9541(13)60560-1 RITCHER, Hermann Eberhard. Arzneitaschenbuch zur: Farmacopea Germanica. 5 ed. 178 p. Berlin: Springer Berlin Heidelberg, 1885. ISBN: 978-3-662-39333-8. Disponible en: https://doi.org/10.1007/978-3-662-40374-7 ROP, Otakar; MLCEK, Jiri y JURIKOVA, Tunde. Beta-glucans in higher fungi and their health effects. En: Nutrition Reviews. 2009, vol. 67, no. 11, p. 624–631. Disponible en: https://doi.org/10.1111/j.1753-4887.2009.00230.x SAFDAR, Muhammad N., et al. Extraction and quantification of polyphenols from kinnow (Citrus reticulate L.) peel using ultrasound and maceration techniques. En: Journal of Food and Drug Analysis. 2017, vol. 25, no. 3, p. 488-500. Disponible en: https://doi.org/10.1016/j.jfda.2016.07.010 SALAS DE LA TORRE, N, et al. Deshidratación de hongos comestibles Pleurotus Ostreatus. En: Revista Peruana de Química Ingeniería Química 2003, vol 6, no. 1, p. 55-59. Disponible en: http://revistasinvestigacion.unmsm.edu.pe/index.php/quim/article/viewFile/4490/3576 SANTOS-NEVES, Juliana C. et al. A novel branched αβ-glucan isolated from the basidiocarps of the edible mushroom Pleurotus florida. En: Carbohydrate Polymers. 2008, vol. 73, no. 2, p. 309–314. Disponible en: http://doi.org/10.1016/j.carbpol.2007.11.030 SARANGI, Itisam, et al. Anti-tumor and immunomodulating effects of Pleurotus ostreatus mycelia-derived proteoglycans. En: International Immunopharmacology. 2006, vol. 6, no. 8, p. 1287–1297. Disponible en: https://doi.org/10.1016/j.intimp.2006.04.002 SCHNEIDER, Inga, et al. Lipid lowering effects of oyster mushroom (Pleurotus ostreatus) in humans. En: Journal of Functional Foods. 2011, vol. 3, no. 1, p. 17–24. Disponible en: https://doi.org/10.1016/j.jff.2010.11.004 SEMEDO, Magda C., KARMALI, Amín y FONSECA, Luís. A high throughput colorimetric assay of β-1,3-D-glucans by Congo red dye. En: Journal of microbiological methods. 2015, vol. 109, p. 140–148. Disponible en: https://doi.org/10.1016/j.mimet.2014.12.020 SHAH, Z. A.; ASHRAFF, M. y ISHTIAQ, M. Comparative study on cultivation and yield performance of oyster mushroom (Pleurotus ostreatus) on the different substrates (wheat straw, leaves, sawdust). En: Pak J Nut. 2004, vol. 3, no. 3, p. 158–160. Disponible: https://doi.org/10.3923/pjn.2004.158.160 SHI, Lei. Bioactivities, isolation and purification methods of polysaccharides from natural products: A review. En: International Journal of Biological Macromolecules. 2015, vol. 92, p. 37–48. Disponible en: https://doi.org/10.1016/j.ijbiomac.2016.06.100 SINGLETON, Vernon L.; ORTHOFER, Rudolf y LAMUELA RAVENTÓS, Rosa M. Analysis of total phenols and other oxidation substrates and antioxidants by means of FolinCiocalteu reagent. En: Methods in Enzymology. 1999, vol. 299, p. 152–178. Disponible en: http://doi.org/10.1016/S0076-6879(99)99017-1 SMIDERLE, Fhernanda R, et al. A 3-O-methylated mannogalactan from Pleurotus pulmonarius: Structure and antinociceptive effect. En: Phytochemistry. 2008, vol. 69, p.2731–2736. Disponible en: https://doi.org/10.1016/j.phytochem.2008.08.006 SMIDERLE, Fhernanda R, et al. Anti-inflammatory and analgesic properties in a rodent model of a (1-->3), (1-->6)-linked beta-glucan isolated from Pleurotus pulmonarius. En: European Journal of Pharmacology. 2008, vol. 597, no. 1–3, p. 86–91. Disponible en: https://doi.org/10.1016/j.ejphar.2008.08.028 SMITH, JF; LÓPEZ MARTÍNEZ, de Alva, MARTÍNEZ CARRERA, Daniel. La producción comercial de hongos comestibles en Bolivia y Colombia. En: MARTÍNEZ-CARRERA, Daniel, et al. Hacia un Desarrollo sustentable de Producción-Consumo de los Hongos Comestibles y Medicinales en Latinoamérica: Avances y Perspectivas en el siglo XXI. Puebla: Red Latinoamericana de Hongos Comestibles y Medicinales-COLPOS-UNSCONACYT-AMC-UAEMUPAEP-IMINAP, 2010. p. 425–436. ISBN 970-9752-01-4. SMITH, Roger M. Before the injection - Modern methods of sample preparation for separation techniques. En: Journal of Chromatography A. 2003, vol. 1000, no. 1–2, p. 3–27. Disponible en: https://doi.org/10.1016/S0021-9673(03)00511-9 SOOD, Ankita y GUPTA, Mahesh. Extraction process optimization for bioactive compounds in pomegranate peel. En: Food Bioscience. 2015, vol. 12, p. 100–106 Disponible en: https://doi.org/10.1016/j.fbio.2015.09.004 SUÁREZ ARANGO, Carolina y NIETO, Ivonne Jeannette. Cultivo biotecnológico de macrohongos comestibles: una alternativa en la obtención de nutracéuticos. En: Revista Iberoamericana de Micología. 2013, vol. 30, no. 1, p. 1–8. Disponible en: https://doi.org/10.1016/j.riam.2012.03.011 SULISTIANY, Henny, et al. Production of Fruiting Body and Antioxidant Activity of Wild Pleurotus. En: HAYATI Journal of Biosciences, 2016, vol. 23, no. 4, p. 191–195. Disponible en: https://doi.org/10.1016/J.HJB.2016.07.003 SUN, Wu Ping, et al. Comparison of the effects of nicotinic acid and nicotinamide degradation on plasma betaine and choline levels. En: Clinical Nutrition. 2017, vol, 36, no. 4, p. 1136–1142. Disponible en: https://doi.org/10.1016/j.clnu.2016.07.016 SUN, Yongxu y LIU, Jicheng. Purification, structure and immunobiological activity of a water-soluble polysaccharide from the fruiting body of Pleurotus ostreatus. En: Bioresource Technology. 2009, vol. 100, no. 2, p. 983–986. Disponible en: https://doi.org/10.1016/j.biortech.2008.06.036 SUN, Yongxu, et al. Technology optimization for polysaccharides (POP) extraction from the fruiting bodies of Pleurotus ostreatus by Box-Behnken statistical design. En: Carbohydrate Polymers. 2010, vol. 80, no. 1, p. 242–247. Disponible en: https://doi.org/10.1016/j.carbpol.2009.11.018 SZWENGIEl, Artur y STACHOWIAK, Bárbara. Deproteinization of water-soluble ß-glucan during acid extraction from fruiting bodies of Pleurotus ostreatus mushrooms. En: Carbohydrate Polymers. 2016, vol. 146, p. 310–319. Disponible en: https://doi.org/10.1016/j.carbpol.2016.03.015 SYNYTSYA, Andriy, et al. Glucans from fruit bodies of cultivated mushrooms Pleurotus ostreatus and Pleurotus eryngii: Structure and potential prebiotic activity. En: Carbohydrate Polymers. 2009, vol76, no.4, p. 548–556. Disponible en: http://doi.org/10.1016/j.carbpol.2008.11.021 SYNYTSYA, Andriy y NOVÁK, Miroslav. Structural diversity of fungal glucans. En: Carbohydrate Polymers. 2013, vol. 92, no. 1, p. 792–809. Disponible en: https://doi.org/10.1016/j.carbpol.2012.09.077 TAOFIQ, Oludemi, et al. Mushrooms extracts and compounds in cosmetics, cosmeceuticals and nutricosmetics-A review. En: Industrial Crops and Products. 2016, vol. 90, p. 38–48. Disponible en: https://doi.org/10.1016/j.indcrop.2016.06.012 TAOFIQ, Oludemi, et al. UV-irradiated mushrooms as a source of vitamin D2: A review. En: Trends in Food Science & Technology. 2017, vol. 70, p. 82-74. Disponible en: https://doi.org/10.1016/j.tifs.2017.10.008 TEHRANI, Mohammad Hassan Houshdar, et al. Search for Proteins in the Liquid Extract of Edible Mushroom, Agaricusbisporus, and Studying their Antibacterial Effects. En: Iran J Pharm Res. 2012 Winter, vol 11, p. 145–150. TERRY, Paul, et al. Fruit, vegetables, dietary fiber, and risk of colorectal cancer. En: Journal of the National Cancer Institute. 2001, vol. 93, no 7, pp. 525–533. Disponible en: https://doi.org/10.1093/jnci/93.7.525 THORPE, Edgar y THORPE, Showick. The Pearson General Knowledge Manual. India: Pearson, 2010. p. B27. ISBN 978-81-317-2790-4. TONG, Haibin, et al. Structural characterization and in vitro antitumor activity of a novel polysaccharide isolated from the fruiting bodies of Pleurotus ostreatus. En: Bioresource Technology. 2009, vol. 100, no. 4, p. 1682–1686. Disponible en: https://doi.org/10.1016/j.biortech.2008.09.004 TORRES-CABRA, Eneida; HERNÁNDEZ-FERNÁNDEZ, Javier y PÉREZ-RUBIANO, Claudia. Cuantificación de proteínas totales en extractos crudos de cepas nativas de Bacillus thuringiensis aisladas de Boyacá y Cundinamarca. En: Conexión Agropecuaria JDC. 2013, vol. 3, no. 2, p. 37–43. Disponible en: http://www.revistasjdc.com/main/index.php/conexagro/article/view/314 UNEKWU, Hamzah Rabiat, et al. Phytochemical screening and antioxidant activity of methanolic extract of selected wild edible Nigerian mushrooms. En: Asian Pacific Journal of Tropical Disease. 2014, vol. 4, no. S1. Disponible en: https://doi.org/10.1016/S2222-1808(14)60431-X VALVERDE, Elizabeth y DOS SANTOS, Macedo. Extracción de materias primas vegetales. En: PINZÓN, Roberto. Fundamentos de Tecnología de Productos Fitoterapéuticos. Bogotá D.C.: Área de Ciencia y Tecnología del Convenio Andrés Bello & Red Iberoamericana de Productos Fitofarmacéuticos (RIPROFITO) del subprograma X del CYTED, 2000. p. 38. ISBN 9586980014. VALVERDE, María Elena; HERNÁNDEZ-PEREZ, Talía y PAREDES-LÓPEZ, Octavio. Edible mushrooms: improving human health and promoting quality life. En: Int J Microbiol. 2013, p. 1–14. Disponible en: https://doi.org/10.1155/2015/376387 VAMANU, Emanuel. In vitro antioxidant and antimicrobial activities of two edible mushroom mycelia obtained in the presence of different nitrogen sources. En: Journal of Medicinal Food. 2013, vol. 16, no. 2, p. 155–166. Disponible en: https://doi.org/10.1089/jmf.2012.0030 WANG, Hexiang; GAO, Jiquan y NG, T. B. A new lectin with highly potent antihepatoma and antisarcoma activities from the oyster mushroom Pleurotus ostreatus. En: Biochemical and biophysical research communications. 2000. Vol. 275, nol. 3, p. 810– 816. Disponible en: https://doi.org/10.1006/bbrc.2000.3373 WANG, Hexiang X. y NG, T. B. Isolation of a novel ubiquitin-like protein from Pleurotus ostreatus mushroom with anti-human immunodeficiency virus, translation-inhibitory, and ribonuclease activities. En: Biochemical and biophysical research communications. 2000, vol. 276, no. 2, p. 587–593. Disponible en: https://doi.org/DOI 10.1006/bbrc.2000.3540 WASSER, S. P. Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides. En: Appl Microbiol Biotechnol. 2002, Vol. 60, p. 258–274. Disponible en: https://doi.org/10.1007/s00253-002-1076-7 WILDMAN, Robert E. C. y KELLEY, Mike. Nutraceutical and Functional Foods. En: Handbook of Nutraceuticals and Functional Foods. 2 ed. Boca Raton, Florida: Robert E. C. Wildman, 2007. p. 1–22. Disponible en: https://doi.org/10.1201/9781420006186 XIA, Fengguo, et al. Antioxidant effects of a water-soluble proteoglycan isolated from the fruiting bodies of Pleurotus ostreatus. En: Journal of the Taiwan Institute of Chemical Engineers. 2011, vol. 42, no. 3, p. 402–407. Disponible en: https://doi.org/10.1016/j.jtice.2010.08.012 XU, Xiaofei, et al. Bioactive proteins from mushrooms. En: Biotechnology Advances. 2011, vol. 29, no. 6, p. 667–674. Disponible en: https://doi.org/10.1016/j.biotechadv.2011.05.003 YAN, Bingju; JING, Liying y WANG, Jun. A polysaccharide (PNPA) from Pleurotus nebrodensis offers cardiac protection against ischemia–reperfusion injury in rats. En: Carbohydr Polym. 2015, vol. 133, p. 1–7. Disponible en: https://doi.org/10.1016/j.carbpol.2015.06.076 YANG, Qi, et al. Gastroprotective activities of a polysaccharide from the fruiting bodies of Pleurotus ostreatus in rats. En: International Journal of Biological Macromolecules. 2012, vol. 50, no. 5, p. 1224–1228. Disponible en: https://doi.org/10.1016/j.ijbiomac.2012.03.020 YONG NAM, Sang y MOO LEE, Young. Pervaporation separation of methanol/methyl tbutyl ether through chitosan composite membrane modified with surfactants. En: Journal of Membrane Science. 1999, vol. 157, no. 1, p. 63–71. https://doi.org/10.1016/S0376-7388(98)00368-8 YOSHIOKA, Yûko, et al. Antitumor polysaccharides from P. ostreatus (Fr.) quél.: Isolation and structure of a β-glucan. En: Carbohydrate Research. 1985, vol. 140, no. 1, p. 93– 100. Disponible en: https://doi.org/10.1016/0008-6215(85)85052-7 YUSEF, Hasan M., THRELFALL, D. R. y GOODWIN, T. W. Some lipids of the oidia of Pleurotus ostreatus. En: Phytochemistry. 1965, vol. 4, no. 4, p. 559–562. Disponible en: https://doi.org/10.1016/S0031-9422(00)86216-0 ZEKOVIĆ, Djordje B, et al. Natural and Modified (1→3)-β-D-Glucans in Health Promotion and Disease Alleviation. En: Critical Reviews in Biotechnology. 2005, vol. 25, no. 4, p. 205–230. Disponible en: https://doi.org/10.1080/07388550500376166 ZERVAKIS, Georgios y BALIS, Constantinos. A pluralistic approach in the study of Pleurotus species with emphasis on compatibility and physiology of the European morphotaxa. En: Mycological Research. 1996, vol. 100, no. 6, p. 717–731. Disponible en: https://doi.org/10.1016/S0953-7562(96)80205-X ZHANG, Chen, et al. Antioxidant and hepatoprotective activities of intracellular polysaccharide from Pleurotus eryngii SI-04. En: Int J Biol Macromol. 2016, vol. 91, p. 568–577. Disponible en: https://doi.org/10.1016/j.ijbiomac.2016.05.104 ZHANG, Chengdong, et al. Edible fungus degrade bisphenol A with no harmful effect on its fatty acid composition. En: Ecotoxicology and Environmental Safety. 2015, vol. 118, p. 126–132. Disponible en: https://doi.org/10.1016/j.ecoenv.2015.04.020 ZHANG, Jie, et al. Antitumor polysaccharides from a Chinese mushroom, “yuhuangmo,” the fruiting body of Pleurotus citrinopileatus. En: Bioscience, biotechnology, and biochemistry. 1994, vol. 58, no. 7, p. 1195–1201. Disponible en: https://doi.org/10.1271/bbb.58.1195 ZHANG, Yan, et al. Antidiabetic effect of polysaccharides from Pleurotus ostreatus in streptozotocin-induced diabetic rats. En: International Journal of Biological Macromolecules. 2016, vol. 83, p. 126–132. Disponible en: https://doi.org/10.1016/j.ijbiomac.2015.11.045 ZHANG, Yan, et al. Polysaccharides from Pleurotus ostreatus alleviate cognitive impairment in a rat model of Alzheimer’s disease. En: International Journal of Biological Macromolecules. 2016, vol. 92, p. 935–941. Disponible en: https://doi.org/10.1016/j.ijbiomac.2016.08.008 ZHANG, Yan et al. Regulating dyslipidemia effect of polysaccharides from Pleurotus ostreatus on fat-emulsion-induced hyperlipidemia rats. En: International Journal of Biological Macromolecules. 2017, vol. 101, p. 107–116. Disponible en: https://doi.org/10.1016/J.IJBIOMAC.2017.03.084 ZHANG, Weimin, et al. Feeding with supplemental squalene enhances the productive performance in boars. En: Animal Reproduction Science. 2008, vol. 104, no. 2–4, p. 445–449. Disponible en: https://doi.org/10.1016/j.anireprosci.2007.08.003 ZHANG, Yunxia, et al. Characterization and in vitro antioxidant activities of polysaccharides from Pleurotus ostreatus. En: International Journal of Biological Macromolecules. 2012, vol. 51, no. 3, p. 259–265. Disponible en: https://doi.org/10.1016/j.ijbiomac.2012.05.003 ZHU, Fengmei, et al. Beta-glucans from edible and medicinal mushrooms: Characteristics, physicochemical and biological activities. En: Journal of Food Composition and Analysis. 2015, vol. 41, p. 165–173. Disponible en: https://doi.org/10.1016/j.jfca.2015.01.019 |
| dc.relation.indexed.spa.fl_str_mv |
N/A |
| dc.rights.spa.fl_str_mv |
Derechos Reservados - Universidad de los Llanos, 2018 |
| dc.rights.uri.spa.fl_str_mv |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| dc.rights.license.spa.fl_str_mv |
Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0) |
| dc.rights.accessrights.spa.fl_str_mv |
info:eu-repo/semantics/openAccess |
| dc.rights.coar.spa.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
| rights_invalid_str_mv |
Derechos Reservados - Universidad de los Llanos, 2018 https://creativecommons.org/licenses/by-nc-nd/4.0/ Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0) http://purl.org/coar/access_right/c_abf2 |
| eu_rights_str_mv |
openAccess |
| dc.format.extent.spa.fl_str_mv |
166 páginas |
| dc.format.mimetype.spa.fl_str_mv |
application/pdf |
| dc.publisher.spa.fl_str_mv |
Universidad de los Llanos |
| dc.publisher.faculty.spa.fl_str_mv |
Facultad de Ciencias Agropecuarias y Recursos Naturales |
| dc.publisher.place.spa.fl_str_mv |
Villavicencio |
| institution |
Universidad de los Llanos |
| bitstream.url.fl_str_mv |
https://dspace7-unillanos.metacatalogo.org/bitstreams/b173591d-213d-4578-8e25-598240f17e0b/download https://dspace7-unillanos.metacatalogo.org/bitstreams/11fe1979-0b24-44f5-9e02-3d70dc94d5ea/download https://dspace7-unillanos.metacatalogo.org/bitstreams/447697c7-7cc4-4734-9e78-ee02601285d2/download https://dspace7-unillanos.metacatalogo.org/bitstreams/938935c3-8411-44ee-8923-d8416c1aea10/download https://dspace7-unillanos.metacatalogo.org/bitstreams/4c098ff3-afac-4c83-8b6a-6d237e839533/download https://dspace7-unillanos.metacatalogo.org/bitstreams/80cf96e4-dae4-4f4f-a078-6499e2b1aba6/download https://dspace7-unillanos.metacatalogo.org/bitstreams/b4c4f66c-474e-40f0-941e-dde607fb7605/download |
| bitstream.checksum.fl_str_mv |
031fd282a5584ef4467357258c6619d0 d0829f1f2ca46a455887b93ce347aa5c f661acf14bedbf9f5d13897a0387e751 f4da2b5d9aded2295c4131ed3e0e2bb0 e1c06d85ae7b8b032bef47e42e4c08f9 e9fb06ea87d9ba27e9185df0c92073cd 60568eb98b8482e5234ef28f7c874a4f |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositorio Universidad de Los Llanos |
| repository.mail.fl_str_mv |
repositorio@unillanos.edu.co |
| _version_ |
1808490979201646592 |
| spelling |
Jiménez Forero, Javier2c4c4b7014465dd9e4d379b438bb9137Pineda Insuasti, Julio Amilcarbf796513604db9bae41165ee5f0f9c88Duarte Trujillo, Astrid Stefanía885d699da62055d6bdc3b48d05cc0c2aGonzález Trujillo, Camila Alejandrabf4065dd64561dfd93a034964d89a3e32023-07-14T14:54:35Z2023-07-14T14:54:35Z2018Duarte Trujillo, Astrid S., & González Trujillo, Camila A. (2018). Evaluación del proceso de extracción de sustancias bioactivas de Orellana (Pleurotus Ostreatus) por maceración dinámica [Trabajo de grado, Universidad de los Llanos]. Repositorio digital Universidad de los Llanos.https://repositorio.unillanos.edu.co/handle/001/2939Universidad de los LlanosRepositorio digital Universidad de los Llanoshttps://repositorio.unillanos.edu.co/Incluye figuras y tablas.La orellana (Pleurotus ostreatus) es un hongo nutracéutico cuya acción farmacológica ha sido ampliamente reportada en la literatura. La maceración es un método sencillo y económico de extracción de las sustancias bioactivas del hongo, que no pone en riesgo la biodisponibilidad, pero que presenta baja eficiencia de extracción. En este contexto, el objetivo de este trabajo es evaluar el proceso de extracción de sustancias bioactivas de Orellana por maceración dinámica, para determinar qué tratamiento permite la máxima eficiencia de extracción total y por componentes, analizando a su vez la influencia de los factores de operación.Oyster mushroom (Pleurotus ostreatus) is a nutraceutical fungus whose pharmacological action has been widely reported in the literature. Maceration is a simple and economical method of extracting the bioactive substances from the fungus, which does not jeopardize bioavailability, but which has low extraction efficiency. In this context, the objective of this work is to evaluate the extraction process of bioactive substances of oyster mushroom by dynamic maceration, to determine which treatment allows the maximum total and specific efficiency, analyzing both the influence of the operating factors.Resumen. -- Introducción. -- Objetivos. -- General: -- Específicos: -- Marco teórico y estado del arte. -- Marco teórico. -- Los nutracéuticos. -- Los hongos comestibles como nutracéuticos. -- Las orellanas (pleurotus spp.). -- Sustancias bioactivas de pleurotus ostreatus. -- Los extractos. -- Extractos de orellana. -- Preparación de extractos de orellana por maceración dinámica. -- Eficiencia de extracción. -- Parámetros que afectan la extracción de sustancias bioactivas. -- Estado del arte. -- Metodología. -- Determinación de parámetros de operación. -- Diseño experimental. -- Microorganismos. -- Preparación del material biológico. -- Maceración dinámica. -- Cálculo de la eficiencia de extracción. -- Cuantificación de sustancias bioactivas. -- Carbohidratos totales. -- Azúcares reductores. -- Polisacáridos totales. -- Polifenoles. -- Proteínas. -- Betaglucanos. -- Tratamiento estadístico. -- Resultados y discusión de resultados. -- Evaluación del proceso de extracción en general. -- Análisis del tamaño de partícula. -- Monitoreo de la temperatura. -- Evaluación de eficiencia de extracción. -- Evaluación del proceso de extracción por sustancia bioactiva en particular. -- Cuantificación del contenido de sustancias bioactivas. -- Evaluación de la extracción de carbohidratos totales. -- Evaluación de la extracción de azucares reductores. -- Evaluación de la extracción de polisacáridos totales. -- Evaluación de la extracción de polifenoles totales. -- Evaluación de la extracción de proteínas totales. -- Evaluación de la extracción de betaglucanos. -- Conclusiones. -- Referencias. -- Anexos.PregradoIngeniero(a) AgroindustrialIngeniería Agroindustrial166 páginasapplication/pdfspaUniversidad de los LlanosFacultad de Ciencias Agropecuarias y Recursos NaturalesVillavicencioDerechos Reservados - Universidad de los Llanos, 2018https://creativecommons.org/licenses/by-nc-nd/4.0/Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Evaluación del proceso de extracción de sustancias bioactivas de Orellana (Pleurotus Ostreatus) por maceración dinámicaTrabajo de grado - Pregradoinfo:eu-repo/semantics/bachelorThesisinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_7a1fTexthttp://purl.org/coar/version/c_970fb48d4fbd8a85ACEVEDO, Adolfo y LINARES, Martha. El enfoque y rol del ingeniero industrial para la gestión y decisión en el mundo de las organizaciones. En: Industrial data. 2012. Vol. 15, no. 1, p. 13. Disponible en: http://www.redalyc.org/pdf/816/81624969002.pdfAGRICULTURAL MARKETING RESOURCE CENTER (AMRC). Mushrooms profile. 2014. Recuperado a partir de http://www.agmrc.org/commodities-products/specialtycrops/mushrooms-profile/ALAM, Nuhu et al. Antioxidant Activities and Tyrosinase Inhibitory Effects of Different Extracts from Pleurotus ostreatus Fruiting Bodies. En: Mycobiology. 2010, vol. 38, no. 4, p. 295-301. Disponible en: https://doi.org/10.4489/MYCO.2010.38.4.295ALBERTS, J. F., et al. Degradation of aflatoxin B1 by fungal laccase enzymes. En: International Journal of Food Microbiology. 2009, vol. 135, no. 1, p. 47–52. Disponible en: https://doi.org/10.1016/j.ijfoodmicro.2009.07.022ALBUQUERQUE, Bianca R, et al. Catechin-based extract optimization obtained from Arbutus unedo L. fruits using maceration/microwave/ultrasound extraction techniques. En: Industrial Crops and Products. 2017, Vol. 95, p. 404–415. Disponible en: https://doi.org/10.1016/j.indcrop.2016.10.050AMIRULLAH, Nur Amalina; ZAINAL ABIDIN, Nurhayati y ABDULLAH, Noorlidah. The potential applications of mushrooms against some facets of atherosclerosis: A review. En: Food Research International. 2018, vol. 105, p. 517–536. Disponible en: https://doi.org/10.1016/j.foodres.2017.11.023ANSCOMBE, Jonathan, et al. Nutraceuticals: The front line of the battle for consumer health [en línea]. 2014. Disponible en: https://www.atkearney.comARGENTINA. COMISIÓN PERMANENTE DE LA FARMACOPEA ARGENTINA. Farmacopea Argentina. 7 ed. Buenos Aires: ANMAT, 1996. 2745 p. ISBN 9567419175 Disponible en: http://www.anmat.gov.ar/webanmat/fna/pfds/Farmacopea_Argentina_2013_Ed.7.pdfASSOCIATION OF OFFICIAL ANALYTICAL CHEMISTS [AOAC]. Official methods of analysis of the Association of Official Analytical Chemists. 15th ed. Washington, DC: AOAC; 1990.ÁVILA, Ramona, et al. Contenido de azúcares totales, reductores y no reductores en Agave cocui Trelease. En: Multiciencias. 2012, vol. 12, no. 2, p. 129–135. Disponible en: https://doi.org/10.5897/AJB11.3143AZMIR, J., et al. Techniques for extraction of bioactive compounds from plant materials: A review. En: Journal of Food Engineering. 2013, vol. 117, no. 4, p. 426–436. Disponible en: https://doi.org/10.1016/j.jfoodeng.2013.01.014BAGGIO, Cristiane Hatsuko, et al. Antinociception of β-D-glucan from Pleurotus pulmonarius is possibly related to protein kinase C inhibition. En: International journal of biological macromolecules. 2012, vol. 50, no. 3, p. 872–877. Disponible en: https://doi.org/10.1016/j.ijbiomac.2011.10.023BANO, Zakia y RAJARATHNAM, S. Pleurotus mushrooms. Part II, nutritional value, postharvest physiology, preservation and role as human food. En: CRC Critical Food Science and Nutrition. 1988, vol. 27, no. 2, p. 87-158. Disponible en: http://dx.doi.org/10.1080/10408398809527480BERGENDIOVA, Katarina; TIBENSKA, Elena y MAJTAN, Jurak. Pleuran (β-glucan from Pleurotus ostreatus) supplementation, cellular immune response and respiratory tract infections in athletes. En: European Journal of Applied Physiology. 2011, vol. 111, no. 9, p. 2033–2040. Disponible en: https://doi.org/10.1007/s00421-011-1837-zBERNAL RODRÍGUEZ, Carlos Alfonso. Contribución al estudio farmacotécnico del extracto estandarizado de frutos de Physalis peruviana L. con miras a la obtención de un producto fitoterapéutico. Tesis de Magíster en Ciencias Farmacéuticas. Bogotá D.C.: Universidad Nacional de Colombia. Facultad de farmacia, 2012. p. 5. Disponible en: http://www.bdigital.unal.edu.co/9016/1/192546.2012.pdfBERNHOFT, Aksel. Bioactive Compounds in Plants: Benefits and Risks for Man and Animals. En: FORLAG, Novus. Proceedings from a Symposium Held in Norwegian Academy of Science and Letters. 13 - 14 November, 2008. Oslo: Det Norske Videnskaps-Akademi. 2010, p. 11–17. ISBN 978-82-7099-583-7.BHATTACHARYA, M.; SRIVASTAV, P. P. y MISHRA, H. N. Optimization of process variables for supercritical fluid extraction of ergothioneine and polyphenols from Pleurotus ostreatus and correlation to free-radical scavenging activity. En: The Journal of Supercritical Fluids. 2014, vol. 95, p. 51-59. Disponible en: https://doi.org/10.1016/j.supflu.2014.07.031BONATTI, Mariane, et al. Evaluation of Pleurotus ostreatus and Pleurotus sajor-caju nutritional characteristics when cultivated in different lignocellulosic wastes. En: Food Chemistry. 2004, vol. 88, no. 3, p. 425–428. Disponible en: https://doi.org/10.1016/j.foodchem.2004.01.050BRADFORD, Marion M. A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding. En: Analytical Biochemistry. 1976, vol. 72, p. 248–254. Disponible en: http://hoffman.cm.utexas.edu/courses/bradford_assay.pdfBRAVO, Karent E., et al. Desarrollo de un método para la extracción de polifenol oxidasa de uchuva (Physalis peruviana l.) y aislamiento por sistemas bifásicos acuosos. En: Vitae, vol. 18, no. 2, p. 124–132. Disponible en http://www.scielo.org.co/pdf/vitae/v18n2/v18n2a03.pdfBRECHTEL, Rolf; WÄTZIG, Hermann y RÜDIGER, Harold. The lectin from the mushroom Pleurotus ostreatus: A phosphatase-activating protein that is closely associated with an α-galactosidase activity: A part of this paper has been presented as a preliminary report at the 17th interlec. Meeting 1997 in Würzburg, Germany. En: Plant Science. 2001, vol. 160, no. 5, p. 1025–1033. Disponible en: https://doi.org/10.1016/S01689452(01)00349-1CANADÁ. AGRICULTURE AND AGRI-FOOD. Consumer trends: functional foods. Market Analysis Report. El Ministerio: December, 2009. p. 4. Disponible en: https://www.gov.mb.ca/agriculture/market-prices-and-statistics/food-and-value-addedagriculture-statistics/pubs/consumer_trends_functional_foods_en.pdfCARDONA URREA, Luis Fernando. Anotaciones acerca de la bromatología y el cultivo del hongo comestible Pleurotus ostreatus. En: Crónica Forestal y del Medio Ambiente. 2001, vol. 16, p. 99–119.CHANG, Shu-Ting y MILES, Philip G. Mushrooms: Cultivation, nutritional value, medicinal effect, and environmental impact. 2. ed. Florida: CRC Press, 2004. p. 8. ISBN 0-84931043-1.CHAUHAN, Baby, et al. Current concepts and prospects of herbal nutraceutical: A review. En: J Adv Pharm Technol Res. 2013, vol. 4, no. 1, p. 4–8. Disponible en: https://doi.org/10.4103/2231-4040.107494CHEN, Lei, et al. Cell wall structure of mushroom sclerotium (Pleurotus tuber regium): Part 1. Fractionation and characterization of soluble cell wall polysaccharides. En: Food Hydrocolloids. 2014, vol. 36, p. 189–195. Disponible en: https://doi.org/10.1016/j.foodhyd.2013.09.023CHEN, Shin Yu, et al. Contents of lovastatin, γ-aminobutyric acid and ergothioneine in mushroom fruiting bodies and mycelia. En: LWT - Food Science and Technology. 2012, vol. 47, no. 2, p. 274–278. Disponible en: https://doi.org/10.1016/j.lwt.2012.01.019CHITIVA JARAMILLO, Adriana, et al. Contribución al estudio de microhongos filamentosos en los ecosistemas Páramo de Guasca y El Tablazo. Estudio preliminar de mohos de páramos colombianos. Bogotá D.C.: Universidad Pontificia Bolivariana, 2007. p. 3. Disponible en: http://www.javeriana.edu.co/gifuj/hongos_%20ecosistemas_%20paramo.pdfCHILDS, Nancy M. Obesity policy: Opportunities for Funcional Food Market Growth. En: Handbook of Nutraceuticals and Functional Foods. 2 ed. Boca Raton, Florida: Robert E. C. Wildman, 2007. p. 1–22. ISBN: 978-1-4200-0618-6. Disponible en: https://doi.org/10.1201/9781420006186CHOBOT, Vladimir, et al. Ergosta-4,6,8,22-tetraen-3-one from the edible fungus, Pleurotus ostreatus (oyster fungus). En: Nutrition. 1997, vol. 45, no. 8, p. 1669–1671. Disponible en: https://doi.org/10.1016/S0031-9422(97)00249-5CHOI, Jae Ho et al. Topical application of Pleurotus eryngii extracts inhibits 2,4dinitrochlorobenzene-induced atopic dermatitis in NC/Nga mice by the regulation of Th1/Th2 balance. En: Food and Chemical Toxicology. 2013, vol. 53, p. 38–45. Disponible en: https://doi.org/10.1016/j.fct.2012.11.025CHOU, Youn-Min; POLANSKY, Alan M y MASON, Robert L. Transforming non-normal data to normality in statistical process control. En: Journal of Quality Technology. 1998, vol. 30, no. 2, p. 133–141. Disponible en: https://goo.gl/zzmnWRCILERDZIC, Jasmina, et al. Antioxidant and Antifungal Potential of Pleurotus ostreatus and Agrocybe cylindracea Basidiocarps and Mycelia. En: Current Pharmaceutical Biotechnology. 2015, vol. 17, no. 2, p. 179–186. Disponible en: http://www.ingentaconnect.com/content/ben/cpb/2015/00000016/00000002/art00010COLOMBIA. DEPARTAMENTO NACIONAL DE PLANEACIÓN (DNP). Bases del Plan Nacional de Desarrollo 2014-2018. Bogotá D.C.: El departamento, 2014. 783 p. Disponible en: https://colaboracion.dnp.gov.co/cdt/prensa/bases%20plan%20nacional%20de%20des arrollo%202014-2018.pdfCOLOMBIA. MINISTERIO DE LA PROTECCIÓN SOCIAL. Decreto Número 2266 (14, julio, 2004). Por el cual se reglamentan los regímenes de registros sanitarios, y de vigilancia y control sanitario y publicidad de los productos fitoterapéuticos. Bogotá D.C.: El Ministerio, 2004. p. 3. Disponible en: http://biblioteca.saludcapital.gov.co/img_upload/03d591f205ab80e521292987c313699 c/decreto_2266_2004.pdfCONRAD, Fritz y RÜDIGER, Harold. The lectin from Pleurotus ostreatus: Purification, characterization and interaction with a phosphatase. En: Phytochemistry. 1994, vol. 36, no. 2, p. 277–283. Disponible en: https://doi.org/10.1016/S0031-9422(00)97061-4ĆUJIĆ, Nada, et al. Optimization of polyphenols extraction from dried chokeberry using maceration as traditional technique. En: Food Chemistry. 2016, vol. 194, p. 135–142. Disponible en: https://doi.org/10.1016/j.foodchem.2015.08.008DALONSO, Nicole, et al. Characterization and antineoplasic effect of extracts obtained from Pleurotus sajor-caju fruiting bodies. En: Applied Biochemistry and Biotechnology. 2010, vol. 160, no. 8, p. 2265 – 2274. Disponible en: https://doi.org/10.1007/s12010009-8678-9DEEPALAKSHMI, Krishnamoorthy y MIRUNALINI, Sankaran. Efficacy of Pleurotus ostreatus (Jacq. Ex Fr.) P. kumm. on 7,12-dimethylbenz(a)anthracene induced mammary carcinogenesis in female Sprague-Dawley rats. En: New Horizons in Translational Medicine. 2016, vol. 3, no. 2, p. 73–82. Disponible en: https://doi.org/10.1016/j.nhtm.2016.06.002DEVI, K. Sanjana P, et al. Characterization and lectin microarray of an immunomodulatory heteroglucan from Pleurotus ostreatus mycelia. En: Carbohydrate Polymers. 2013, vol. 94, no. 2, p. 857–865. Disponible en: https://doi.org/10.1016/j.carbpol.2013.02.017DEVI, K. Sanjana P, et al. Immune augmentation and Dalton’s Lymphoma tumor inhibition by glucans/glycans isolated from the mycelia and fruit body of Pleurotus ostreatus. En: International Immunopharmacology. 2015, vol. 25, no. 1, p. 207–217. Disponible en: https://doi.org/10.1016/j.intimp.2015.01.026DIEM, Konrad. Tablas Cientificas: Documenta Geigy. Basilea: J.R. Geigy S. A., 1965. p. 320-321DUBOIS, Michel, et al. Colorimetric method for determination of sugars and related substances. En: Analytical Chemistry. 1956, vol. 28, no. 3, p. 350–356. Disponible en: https://doi.org/10.1021/ac60111a017ELISASHVILI, Vladimir, et al. Use of Pleurotus dryinus for lignocellulolytic enzymes production in submerged fermentation of mandarin peels and tree leaves. En: Enzyme and Microbial Technology. 2006, vol. 38, no.7, p. 998–1004. Disponible en: https://doi.org/10.1016/j.enzmictec.2005.08.033EL-FAKHARANY, Esmail M., et al. Oyster Mushroom Laccase Inhibits Hepatitis C Virus Entry into Periph- eral Blood Cells and Hepatoma Cells. En: Protein & Peptide Letters. 2010, vol. 17, no. 1, p. 1031–1039. Disponible en: https://doi.org/10.2174/092986610791498948FACCHINI, Jean Mary, et al. Antitumor activity of Pleurotus ostreatus polysaccharide fractions on Ehrlich tumor and Sarcoma 180. En: International Journal of Biological Macromolecules. 2014, vol. 68, p. 72–77. Disponible en: https://doi.org/10.1016/J.IJBIOMAC.2014.04.033FINIMUNDY, Tiane C., et al. Aqueous extracts of Lentinula edodes and Pleurotus sajorcaju exhibit high antioxidant capability and promising in vitro antitumor activity. En: Nutr. Res. 2013, vol. 33, p. 76–84. Disponible en: https://doi.org/10.1016/j.nutres.2012.11.005FLORES, Maria Victoria, VOGET, C. y ERTOLA, J. Permeabilization of yeast cells (Kluyveromyces lactis) with organic solvents. En: Enzyme and Microbial Technology. 1994, vol. 16, no. 4, p. 340–346. Disponible en: https://doi.org/10.1016/01410229(94)90177-5FONTES VIEIRA, Patrícia A. et al. Antioxidant activities, total phenolics and metal contents in Pleurotus ostreatus mushrooms enriched with iron, zinc or lithium. En: LWT - Food Science and Technology. 2013, vol. 54, no. 2, p. 421–425. Disponible en: https://doi.org/10.1016/j.lwt.2013.06.016FOOD AND AGRICULTURE ORGANIZATION OF THE UNITED NATIONS (FAO). Statistics. [en línea]. Disponible en: http://faostat3.fao.org/home/EAO, Wenjuan, et al. Mushroom lectin enhanced immunogenicity of HBV DNA vaccine in C57BL/6 and HBsAg-transgenic mice. En: Vaccine. 2013, vol. 31, no. 18, p. 2273– 2280. Disponible en: https://doi.org/10.1016/j.vaccine.2013.02.062GASECKA, Monika, et al. The effect of selenium on phenolics and flavonoids in selected edible white rot fungi. En: LWT - Food Science and Technology. 2015, vol. 63, no, 1, p. 726–731. Disponible en: https://doi.org/10.1016/j.lwt.2015.03.046GIL RAMÍREZ, Alicia, et al. Mushrooms do not contain flavonoids. En: Journal of Functional Foods. 2016, vol. 25, p. 1–13. Disponible en: https://doi.org/10.1016/j.jff.2016.05.005GIL RAMÍREZ, Alicia, et al. Screening of edible mushrooms and extraction by pressurized water (PWE) of 3-hydroxy-3-methyl-glutaryl CoA reductase inhibitors. En: Journal of Functional Foods. 2012, vol. 5, p. 244-250. Disponible en: https://doi.org/10.1016/j.jff.2012.10.013GOMES CORRÊA, Rúbia Carvalho, et al. Biotechnological, nutritional and therapeutic uses of Pleurotus spp. (Oyster mushroom) related with its chemical composition: A review on the past decade findings. En: Trends in Food Science & Technology. 2016, vol. 50, p. 103–117. Disponible en: https://doi.org/10.1016/j.tifs.2016.01.012GRIFFIN, Roger D. Principles of Hazardous Materials Management. 2. ed. Boca Raton: CRC Press, 2009. P. 216.ISBN 9781420089714.GULLÓN, Beatriz, et al. Rutin: A review on extraction, identification and purification methods, biological activities and approaches to enhance its bioavailability. En: Trends in Food Science & Technology. 2017, no. 67. p. 220-235. Disponible en: https://doi.org/10.1016/j.tifs.2017.07.008GUNAWARDENA, Dhanushka, et al. Anti-inflammatory effects of five commercially available mushroom species determined in lipopolysaccharide and interferon-γ activated murine macrophages. En: Food Chemistry. 2014, vol. 148, p. 92–96. Disponible en: https://doi.org/10.1016/j.foodchem.2013.10.015HAPSARI, Riani; ELYA, Berna y AMIN, Juheini. Formulation and evaluation of antioxidant and tyrosinase inhibitory effect from gel containing the 70% ethanolic Pleurotus ostreatus extract. En: Int. J. Med. Arom. Plants. 2012, vol. 2, no. 1, p. 135–140. Disponible en: https://goo.gl/b3nSXEHASHIM, Shima N. N. S., et al. Recovery of ergosterol from the medicinal mushroom, Ganoderma tsugae var. Janniae, with a molecularly imprinted polymer derived from a cleavable monomer-template composite. En: Journal of Chromatography A. 2016, vol. 1468, p. 1–9. Disponible en: https://doi.org/10.1016/j.chroma.2016.09.004HATHCOCK, John N., & SHAO, Andrew. Risk assessment for coenzyme Q10 (Ubiquinone). En: Regulatory Toxicology and Pharmacology. 2006, vol. 45, no. 3, p. 282–288. Disponible en: https://doi.org/10.1016/j.yrtph.2006.05.006HU, Shu Hui et al. Antihyperlipidemic and Antioxidant Effects of Extracts from Pleurotus citrinopileatus. En: Journal of Agricultural and Food Chemistry. 2006, vol. 54, no. 6, p. 2103–2110. Disponible en: https://doi.org/10.1021/jf052890dHUANG, Shih Jeng; LIN, Chun Ping y TSAI, Shu Yao. Vitamin D2 content and antioxidant properties of fruit body and mycelia of edible mushrooms by UV-B irradiation. En: Journal of Food Composition and Analysis. 2015, vol. 42, p. 38–45. Disponible en: https://doi.org/10.1016/j.jfca.2015.02.005KEWUCHI, J. C., et al. Moderation of hematological and plasma biochemical indices of sub-chronic salt-loaded rats by aqueous extract of the sclerotia of Pleurotus tuberregium (Fr) Sing’s: Implications for the reduction of cardiovascular risk. En: Journal of Ethnopharmacology. 2013, vol. 150, no. 2, p. 466–476. Disponible en: https://doi.org/10.1016/j.jep.2013.09.002INSTITUTO COLOMBIANO DE NORMALIZACIÓN Y CERTIFICACIÓN. Sistemas de Gestión de la Calidad: fundamentos y vocabulario. NTC-ISO 9000. Bogotá D.C.: El instituto, 2005. p. 10. Disponible en: https://tienda.icontec.org/wp- content/uploads/pdfs/NTC-ISO9000-2015.pdfWALOKUN, Bamidele, et al. Comparative phytochemical evaluation, antimicrobial antioxidant properties of Pleurotus ostreatus. African Journal of Biotechnology. 2007, vol 6, no. 15, p. 1732-1739. Disponible en: http://www.ajol.info/index.php/ajblarticle/download/57767/46134JAYAKUMAR, T., et al. Pleurotus ostreatus, an oyster mushroom, decreases the oxidative stress induced by carbon tetrachloride in rat kidneys, heart and brain. En: ChemicoBiological Interactions. 2008, vol. 176, no. 2–3, p. 108–120. Disponible en: https://doi.org/10.1016/j.cbi.2008.08.006JESENAK, Milos, et al. Anti-allergic effect of Pleuran (β-glucan from Pleurotus ostreatus) in children with recurrent respiratory tract infections. En: Phytotherapy Research. 2014, vol. 28, no. 3, p. 471–474. Disponible en: https://doi.org/10.1002/ptr.5020JESENAK, Milos, et al. Immunomodulatory effect of Pleuran (β-glucan from Pleurotus ostreatus) in children with recurrent respiratory tract infections. En: International Immunopharmacology. 2013, vol. 15, no. 2, p. 395-399. Disponible en: https://doi.org/10.1016/j.intimp.2012.11.020JIAO, Fengping, et al. Processing optimization and anti-oxidative activity of enzymatic extractable polysaccharides from Pleurotus djamor. En: International Journal of Biological Macromolecules. 2017, vol. 98, p. 469–478. Disponible en: https://doi.org/10.1016/J.IJBIOMAC.2017.01.126JOVANOVIĆ, Aleksandra A., et al. Optimization of the extraction process of polyphenols from Thymus serpyllum L. herb using maceration, heat- and ultrasound-assisted techniques. En: Separation and Purification Technology. 2017, vol. 179, p. 369–380. Disponible en: https://doi.org/10.1016/j.seppur.2017.01.055KAKON, A. J.; CHOUDHURY, Md Bazlul Karim y SAHA, Shusmita. Mushroom in an ideal food supplement. En: Journal of Dhaka National Medical College & Hospital. 2012, vol. 18, p. 58-62. Disponible en: http://dx.doi.org/10.3329/jdnmch.v18i1.12243KALARAS, Michael D., et al. Mushrooms: A rich source of the antioxidants ergothioneine and glutathione. En: Food Chemistry. 2017, vol. 233, p. 429–433. Disponible en: https://doi.org/10.1016/j.foodchem.2017.04.109KAWAGISHI, Hirokazu, et al. A lectin from an edible mushroom Pleurotus ostreatus as a food intake-suppressing substance. En: Biochimica et Biophysica Acta - General Subjects. 2000, vol. 1474, no. 3, p. 299–308. Disponible en: https://doi.org/10.1016/S0304-4165(00)00027-1KHAN, Asma Ashraf, et al. Structural, rheological, antioxidant, and functional properties of β–glucan extracted from edible mushrooms Agaricus bisporus, Pleurotus ostreatus and Coprinus attrimentarius. En: Bioactive Carbohydrates and Dietary Fibre. 2017, vol. 11, p. 67–74. Disponible en: https://doi.org/10.1016/J.BCDF.2017.07.006KHARB, Simmi y SINGH, Veena. Nutriceuticals in health and disease prevention. En: Indian Journal of Chemical Biochemistry. 2004, vol. 59, no. 1, p. 50-53. Disponible en: https://doi.org/10.1007/BF02872389KHATUN, Selima, et al. Nutritional qualities and antioxidant activity of three edible oyster mushrooms (Pleurotus spp.). En: NJAS - Wageningen J Life Sci. 2015, vol. 72, p. 1–5. Disponible en: https://doi.org/10.1016/j.njas.2012.03.003KIM, Gyuri, et al. Statin use and the risk of hepatocellular carcinoma in patients at high risk: a nationwide nested case-control study. En: Journal of Hepatology. 2017. In press. Disponible en: https://doi.org/10.1016/j.jhep.2017.10.018KNOP, Doriv; YARDEN, Oded y HADAR, Yitzhak. The ligninolytic peroxidases in the genus Pleurotus: divergence in activities, expression and potencial applications. En: Applied Microbiology and Biotechnology. 2015, vol. 99, p. 1025-1038. Disponible en: https://doi.org/10.1007/s00253-014-6256-8KO, Yuan-Tih y LIN, Yu-Ling. 1,3-D-Glucan Quantification by a Fluorescence Microassay and Analysis of Its Distribution in Foods. En: Journal of agricultural and food chemistry, 2004, vol. 13, p. 3313–3318. Disponible en: https://doi.org/10.1021/jf0354085KOENIG, Steven, et al. Quantitative assay of β-(1,3)–β-(1,6)–glucans from fermentation broth using aniline blue. En: Carbohydrate Polymers. 2017, vol. 174, p. 57–64. Disponible en: https://doi.org/10.1016/j.carbpol.2017.06.047KOMURA, Dirce L., et al. Water-soluble polysaccharides from Pleurotus ostreatus var. florida mycelial biomass. En: International Journal of Biological Macromolecules. 2014, vol. 70, p. 354–359. Disponible en: https://doi.org/10.1016/j.ijbiomac.2014.06.007KONG, Fanli. Anti-tumor and macrophage activation induced by alkali-extracted polysaccharide from Pleurotus ostreatus. En: International Journal of Biological Macromolecules. 2014, vol. 69, p. 561–566. Disponible en: https://doi.org/10.1016/j.ijbiomac.2014.05.045KRINGS, Ulrich y BERGER, Ralf G. Dynamics of sterols and fatty acids during UV-B treatment of oyster mushroom. En: Food Chemistry. 2014, vol. 149, p. 10–14. Disponible en: https://doi.org/10.1016/j.foodchem.2013.10.064LAVI, Iris, et al. An aqueous polysaccharide extract from the edible mushroom Pleurotus ostreatus induces anti-proliferative and pro-apoptotic effects on HT-29 colon cancer cells. En: Cancer Letters. 2006, vol. 244, no. 1, p. 61–70. Disponible en: https://doi.org/10.1016/j.canlet.2005.12.007LEÓN, Orfelio G. y MONTERO, Ignacio. Cómo explicar el concepto de interacción sin estadística: análisis gráfico de todos los casos posibles en un diseño 2 x 2. En: Psicothema. 2001, vol. 13, no. 1, p. 159-165. Disponible en: http://www.redalyc.org/html/727/72713123/LIANG, Zeng-Chin, et al. Utilization of grass plants for cultivation of Pleurotus citrinopileatus. En: International Biodeterioration & Biodegradation. 2009, vol. 63, no. 4, p. 509–514. Disponible en: https://doi.org/10.1016/j.ibiod.2008.12.006LIMA, Marcos Dos Santos, et al. Phenolic compounds, organic acids and antioxidant activity of grape juices produced in industrial scale by different processes of maceration. En: Food Chemistry. 2015, vol. 188, p. 384–392. Disponible en: https://doi.org/10.1016/j.foodchem.2015.04.014LI, Jinyao, et al. Pleurotus ferulae water extract enhances the maturation and function of murine bone marrow-derived dendritic cells through TLR4 signaling pathway. En: Vaccine. 2015, vol. 33, p. 1923–33. Disponible en: https://doi.org/10.1016/j.vaccine.2015.02.063LI, Siqian y SHAH, Nagendra P. Effects of Pleurotus eryngii polysaccharides on bacterial growth, texture properties, proteolytic capacity, and angiotensin-I-converting enzymeinhibitory activities of fermented milk. En: J Dairy Sci. 2015, vol. 98, p. 2949 – 2961. Disponible en: https://doi.org/10.3168/jds.2014-9116LIU, Xiaonan, et al. Extraction and antioxidant activities of intracellular polysaccharide from Pleurotus sp. mycelium. En: International Journal of Biological Macromolecules. 2010, vol. 47, no. 2, p. 116–119. Disponible en: https://doi.org/10.1016/J.IJBIOMAC.2010.05.012LIU, Xinkui et al. Structure characterization and antitumor activity of a polysaccharide from the alkaline extract of king oyster mushroom. En: Carbohydrate Polymers. 2015, vol. 118, p. 101–106. Disponible en: https://doi.org/10.1016/j.carbpol.2014.10.058LLAURADÓ, Gabriel, et al. In-vitro antimicrobial activity and complement/macrophage stimulating effects of a hot-water extract from mycelium of the oyster mushroom Pleurotus sp. En: Innovative Food Science & Emerging Technologies. 2015, vol. 30, p. 177–183. Disponible en: https://doi.org/10.1016/j.ifset.2015.05.002LLAURADÓ, Gabriel, et al. Oral administration of an aqueous extract from the oyster mushroom Pleurotus ostreatus enhances the immunonutritional recovery of malnourished mice. En: Biomedicine and Pharmacotherapy. 2016, vol. 83, p. 1456– 1463. Disponible en: https://doi.org/10.1016/j.biopha.2016.08.067MACÁKOVÁ, Kateřina, et al. Tannins and their Influence on Health. En: UR-RAHMAN, Atta y CHOUDHARY, Muhammad Iqbal (Eds.), Recent Advances in Medicinal Chemistry Recent Advances in Medicinal Chemistry. Amsterdam: Bentham Science Publishers, 2014. p. 159–208. ISBN: 9780128039618MACHADO ROCHA, Leandro. Extracción de materias primas vegetales. En: PINZÓN, Roberto. Fundamentos de Tecnología de Productos Fitoterapéuticos. Bogotá D.C.: Área de Ciencia y Tecnología del Convenio Andrés Bello & Red Iberoamericana de Productos Fitofarmacéuticos (RIPROFITO) del subprograma X del CYTED, 2000. p. 61-70. ISBN 9586980014.MA, Gaoxing, et al. Purification, characterization and antitumor activity of polysaccharides from Pleurotus eryngii residue. En: Carbohydr Polym. 2014, vol. 114, p. 297–305. Disponible en: https://doi.org/10.1016/j.carbpol.2014.07.069MAITY, Kousik, et al. Structural characterization and study of immunoenhancing and antioxidant property of a novel polysaccharide isolated from the aqueous extract of a somatic hybrid mushroom of Pleurotus florida and Calocybe indica variety APK2. En: International Journal of Biological Macromolecules. 2011, Vol. 48, no. 2, p. 304–310. Disponible en: https://doi.org/10.1016/j.ijbiomac.2010.12.003MANZI, Pamela y PIZZOFERRATO, Laura. Beta-glucans in edible mushrooms. En: Food Chemistry. 2000, vol. 68, no. 3, p. 315–318. Disponible en: https://doi.org/10.1016/S0308-8146(99)00197-1MARTÍNEZ-RINCÓN, Leydi Johana. Colombia y Brasil, complejidad logística: ¿verdad o mito? EAFIT, 2016. p. 1. Disponible en: http://hdl.handle.net/10784/11244MARTÍNEZ-SÁNCHEZ, Angel y PÉREZ-PÉREZ, Manuela. R&D project efficiency management in the Spanish industry. En: International Journal of Project Management. 2002. vol. 20, no. 7, p. 545. Disponible en: https://doi.org/10.1016/S0263-7863(01)00024-2MASSADEH, Muhannad I.; FRAIJA, Abeer y FANDIB, Khalid. Effect of Carbon Sources on The Extracellular Lignocellulolytic Enzymetic System of Pleurotus Sajor-Caju. En: Jordan journal of Biological Science. 2010, vol. 3, no.2, p. 51–54. Disponible en: https://eis.hu.edu.jo/deanshipfiles/pub105086141.pdfMATTILA, Pirjo, et al. Basic composition and amino acid contents of mushrooms cultivated in Finland. En: Journal of Agricultural and Food Chemistry. 2002, vol. 50, no. 22, p. 6419–6422. Disponible en: https://doi.org/10.1021/jf020608mMAU, Jeng Leun, et al. Nonvolatile taste components of ear mushrooms. En: Journal of Agricultura and food chemistry. 1998, vol. 46, no.11 p. 4583 – 4586. Disponible en: https://10.1021/jf9805606McCLEAR, Barry y GLENNIE-HOLMES, Malcolm. Enzymatic quantification of (1-3)(1-4)beta-D-Glucan in barley and malt. En: Journal of the Institute of Brewing. 1985, vol. 9, p. 285–295. Disponible en: https://doi.org/10.1002/j.2050-0416.1985.tb04345.xMILLER, Gail Lorenz. Use of Dinitrosalicylic Acid Reagent for Determination of Reducing Sugar. En: Analytical Chemistry. 1959, vol. 31, no. 3, p. 426–428. ISSN 0003-2700. Disponible en: https://doi.org/10.1021/ac60147a030MITRA, Amal K. y RODRÍGUEZ FERNANDEZ, Gisella. Latin America and the Caribbean: assessment of the advances in public health for the achievement of the Millennium Development Goals. En: Int J Environ Res Public Health. 2010, vol. 7, no. 5, p. 2238– 2255. Disponible en: https://doi.org/10.3390/ijerph7052238MITRA, Payel; KHATUA, Somanjana y ACHARYA, Krishnendu. Free radical scavenging and nos activation properties of water soluble crude polysaccharide from Pleurotus ostreatus. En: Asian Journal of Pharmaceutical and Clinical Research. 2013, vol. 6, no. 3, p. 67–70. Disponible en: http://www.ajpcr.com/Vol6Issue3/53.pdfMIZUNO, Masashi, et al. Contents of AntiTumor Polysaccharides in Certain Mushroomsand Their Immunomodulating Activities. En: Food Science and Technology Research2001, vol. 7, no. 1, p. 31–34. Disponible en: https://doi.org/10.3136/fstr.7.31MUÑOZ, Carlos. Cómo elaborar y asesorar una investigación de tesis. 2 ed. Ciudad de México: Pearson educación, 2011. 320 p. Disponible en: http://www.unamerida.com/documentos/bileidis/ElaborarTesis.pdfNASRI, Hamid, et al. New Concepts in Nutraceuticals as Alternative for Pharmaceuticals. En: Int J Prev Med. 2014, vol. 5, no. 12, p. 1487–1499. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4336979/NATTOH, Godfrey, et al. Towards profiling differential distribution of bioactive molecules across four phenologies in Pleurotus djamor R22. En: Asian Pacific J Trop Dis. 2016, vol. 6, no. 6, p. 472–480. Disponible en: https://doi.org/10.1016/S2222-1808(16)6107xNITSCHKE, Jörg, et al. A new colorimetric method to quantify β-1,3-1,6-glucans in comparison with total β-1,3-glucans in edible mushrooms. En: Food chemistry. 2011 vol. 127, no. 2, p. 791–796. Disponible en: https://doi.org/10.1016/j.foodchem.2010.12.149NIKIFOROVA, Svetlana V.; POZDNYAKOVA, Natalia N. y TURKOVSKAYA, Olga V. Emulsifying agent production during PAHs degradation by the white rot fungus Pleurotus Ostreatus D1. En: Current Microbiology. 2009, vol. 58, no. 6, p. 554–558. https://doi.org/10.1007/s00284-009-9367-1NIKSIC, Miomir; KLAUS, Anita y ARGYROPOULOS, Dimitrios. Safety of foods based on mushrooms. En: PRAKASH, Vishweshwaraiah, et al. Regulating Safety of Traditional and Ethnic Foods. Waltham, Massachusetts: Academic Press, 2016. p. 423-425. ISBN 9780128006054.NNADIUKWU, Tochukwu Anthony; MONAGO, C. C. y CHUKU, L. C. Histological Effect of Combined Ethanol Extract of Moringa oleifera and Pleurotus ostreatus on the Pancreas of Alloxan-induced Diabetic Wistar Albino Rats. En: Journal of Applied Life Sciences International. 2016, vol. 5, no. 3, p. 1–8. Disponible en: https://doi.org/10.9734/JALSI/2016/26108ORGANIZACIÓN DE LAS NACIONES UNIDAS (ONU). Objetivos de Desarrollo Sostenible. En: Cumbre Mundial sobre el Desarrollo Sostenible. Recuperado de http://www.un.org/sustainabledevelopment/es/summit/ORGANIZACIÓN MUNDIAL DE LA SALUD (OMS). Informe mundial sobre el envejecimiento y la salud. Estados Unidos: OMS, 2015. 282 p. ISBN: 978-92-4069487 3. Disponible en: http://apps.who.int/iris/bitstream/10665/186466/1/9789240694873_spa.pdfORTIZ MORENO, Martha Lucía. Macromicetos en Zona Rural de Villavicencio. En: Rev Orinoquia. 2010, vol. 14, no. 2, p. 125 – 132. Disponible en: http://orinoquia.unillanos.edu.co/index.php/orinoquia/article/view/68/544PAHILA, Jade et al. Effects of ergothioneine-rich mushroom extracts on lipid oxidation and discoloration in salmon muscle stored at low temperatures. En: Food Chemistry. 2017, vol. 233, p. 273–281. Disponible en: https://doi.org/10.1016/j.foodchem.2017.04.130PALACIOS, Irene. Novel isolation of water-soluble polysaccharides from the fruiting bodies of Pleurotus ostreatus mushrooms. En: Carbohydrate Research. 2012, vol. 358, p. 72–77. Disponible en: https://doi.org/10.1016/j.carres.2012.06.016PALMIERI, Gianna, et al. Copper Induction of Laccase Isoenzymes in the Ligninolytic Fungus Pleurotus ostreatus. En: Applied And Environmental Microbiology. 2000, vol. 66, no 3, pp. 920–924. Disponible en: https://doi.org/10.1128/AEM.66.3.920-924.2000PALMER, Michelle y CHAGUTURU, Rathnam. Academia–pharma partnerships for novel drug discovery: essential or nice to have? En: Expert Opinion on Drug Discovery. 2017, p. 1. Disponible en: https://doi.org/10.1080/17460441.2017.1318124PAPASPYRIDI, Lefki-Maria, et al. Production of bioactive metabolites with pharmaceutical and nutraceutical interest by submerged fermentation of Pleurotus ostreatus in a batch stirred tank bioreactor. En: Procedia Food Science. 2011, vol. 1, no. 11, p. 1746–1752. Disponible en: https://doi.org/10.1016/j.profoo.2011.09.257PATRA, Sukesh, et al. A heteroglycan from the mycelia of Pleurotus ostreatus: Structure determination and study of antioxidant properties. En: Carbohydrate Research. 2013, vol. 368, p. 16–21. Disponible en: https://doi.org/10.1016/j.carres.2012.12.003PEDNEAULT, Karine, et al. Fatty acid profiles of polar and non-polar lipids of Pleurotus ostreatus and P. cornucopiae var. “citrinopileatus” grown at different temperaturas En: Mycological Research. 2007, vol. 111, no. 10, p. 1228–1234. Disponible en: https://doi.org/10.1016/j.mycres.2007.06.014PÉREZ-MARTÍNEZ, Ana S., et al. A perspective on the use of Pleurotus for the development of convenient fungi-made oral subunit vaccines. En: Vaccine. 2015, vol. 33, no. 1, p. 25–33. Disponible en: https://doi.org/10.1016/j.vaccine.2014.10.059PHAT, Chanvorleak; MOON, Bokyung y LEE, Chan. Evaluation of umami taste in mushroom extracts by chemical analysis, sensory evaluation, and an electronic tongue system. En: Food Chemistry. 2016, vol. 192, p. 1068–1077. Disponible en: https://doi.org/10.1016/j.foodchem.2015.07.113PINEDA INSUASTI, Julio Almicar. Desarrollo de una tecnología para la producción a pequeña escala de la biomasa del hongo ostra (Pleurotus ostreatus). Tesis de doctorado en Ciencias Técnicas. Universidad de Camagüey Ignacio Agramonte Loynaz. Facultad de Química. Departamento de Ingeniería Química. 203 p. Disponible en: http://repositorio.educacionsuperior.gob.ec/bitstream/28000/1586/1/TSENESCYT-00704.pdfPLEMENITAŠ, Ana, et al. Steroidogenesis in the fungus Pleurotus ostreatus. En: Comparative Biochemistry and Physiology – B: Biochemistry and Molecular Biology. 1999, vol. 123, no. 2, p. 175–179. Disponible en: https://doi.org/10.1016/S03050491(99)00053-XRADZKI, Wojciech, et al. Effect of processing on the content and biological activity of polysaccharides from Pleurotus ostreatus mushroom. En: LWT - Food Science and Technology. 2016, vol. 66, p. 27–33. Disponible en: https://doi.org/10.1016/j.lwt.2015.10.016RAMESH, CH y PATTAR, Manohar G. Antimicrobial properties, antioxidant activity and bioactive compounds from six wild edible mushrooms of western ghats of Karnataka, India. En: Pharmacognosy Res. 2010, vol. 2, p. 107–112. Disponible en: https://doi.org/10.4103/0974-8490.62953RAMÍREZ-NIÑO, Miguel Ángel. Identificación y Cuantificación de carbohidratos totales. Guía de laboratorio de Química Agroindustrial. Villavicencio, Colombia: Universidad de Los Llanos, 2017. 4 p.RANA, Tanmoy, et al. Pleurotus florida lectin normalizes duration dependent hepatic oxidative stress responses caused by arsenic in rat. En: Experimental and Toxicologic Pathology. 2012, vol. 64, no. 7–8, p. 665–671. Disponible en: https://doi.org/10.1016/j.etp.2010.12.010REDDY, Gorla V., et al. Utilization of banana waste for the production of lignolytic and cellulolytic enzymes by solid substrate fermentation using two Pleurotus species (P. ostreatus and P. sajor-caju). En: Process Biochemistry. 2003, vol. 38, no. 10, pp. 1457–1462. Disponible en: https://doi.org/10.1016/S0032-9592(03)00025-6REN, Daoyuan, et al. Antioxidant and antitumor effects of polysaccharides from the fungus Pleurotus abalonus. En: Chem Biol Interact. 2015, vol. 237, p. 166–74. Disponible en: https://doi.org/10.1016/j.cbi.2015.06.017REN, Lu, et al. Antibacterial and antioxidant activities of aqueous extracts of eight edible mushrooms. En: Bioactive Carbohydrates and Dietary Fibre. 2014, vol. 3, no. 2, p. 41–51. Disponible en: https://doi.org/10.1016/j.bcdf.2014.01.003REN, Qilong, et al. Recent Advances in Separation of Bioactive Natural Products. En: Chinese Journal of Chemical Engineering. 2013, vol. 21, no. 9, p. 937–952. Disponible en: https://doi.org/10.1016/S1004-9541(13)60560-1RITCHER, Hermann Eberhard. Arzneitaschenbuch zur: Farmacopea Germanica. 5 ed. 178 p. Berlin: Springer Berlin Heidelberg, 1885. ISBN: 978-3-662-39333-8. Disponible en: https://doi.org/10.1007/978-3-662-40374-7ROP, Otakar; MLCEK, Jiri y JURIKOVA, Tunde. Beta-glucans in higher fungi and their health effects. En: Nutrition Reviews. 2009, vol. 67, no. 11, p. 624–631. Disponible en: https://doi.org/10.1111/j.1753-4887.2009.00230.xSAFDAR, Muhammad N., et al. Extraction and quantification of polyphenols from kinnow (Citrus reticulate L.) peel using ultrasound and maceration techniques. En: Journal of Food and Drug Analysis. 2017, vol. 25, no. 3, p. 488-500. Disponible en: https://doi.org/10.1016/j.jfda.2016.07.010SALAS DE LA TORRE, N, et al. Deshidratación de hongos comestibles Pleurotus Ostreatus. En: Revista Peruana de Química Ingeniería Química 2003, vol 6, no. 1, p. 55-59. Disponible en: http://revistasinvestigacion.unmsm.edu.pe/index.php/quim/article/viewFile/4490/3576SANTOS-NEVES, Juliana C. et al. A novel branched αβ-glucan isolated from the basidiocarps of the edible mushroom Pleurotus florida. En: Carbohydrate Polymers. 2008, vol. 73, no. 2, p. 309–314. Disponible en: http://doi.org/10.1016/j.carbpol.2007.11.030SARANGI, Itisam, et al. Anti-tumor and immunomodulating effects of Pleurotus ostreatus mycelia-derived proteoglycans. En: International Immunopharmacology. 2006, vol. 6, no. 8, p. 1287–1297. Disponible en: https://doi.org/10.1016/j.intimp.2006.04.002SCHNEIDER, Inga, et al. Lipid lowering effects of oyster mushroom (Pleurotus ostreatus) in humans. En: Journal of Functional Foods. 2011, vol. 3, no. 1, p. 17–24. Disponible en: https://doi.org/10.1016/j.jff.2010.11.004SEMEDO, Magda C., KARMALI, Amín y FONSECA, Luís. A high throughput colorimetric assay of β-1,3-D-glucans by Congo red dye. En: Journal of microbiological methods. 2015, vol. 109, p. 140–148. Disponible en: https://doi.org/10.1016/j.mimet.2014.12.020SHAH, Z. A.; ASHRAFF, M. y ISHTIAQ, M. Comparative study on cultivation and yield performance of oyster mushroom (Pleurotus ostreatus) on the different substrates (wheat straw, leaves, sawdust). En: Pak J Nut. 2004, vol. 3, no. 3, p. 158–160. Disponible: https://doi.org/10.3923/pjn.2004.158.160SHI, Lei. Bioactivities, isolation and purification methods of polysaccharides from natural products: A review. En: International Journal of Biological Macromolecules. 2015, vol. 92, p. 37–48. Disponible en: https://doi.org/10.1016/j.ijbiomac.2016.06.100SINGLETON, Vernon L.; ORTHOFER, Rudolf y LAMUELA RAVENTÓS, Rosa M. Analysis of total phenols and other oxidation substrates and antioxidants by means of FolinCiocalteu reagent. En: Methods in Enzymology. 1999, vol. 299, p. 152–178. Disponible en: http://doi.org/10.1016/S0076-6879(99)99017-1SMIDERLE, Fhernanda R, et al. A 3-O-methylated mannogalactan from Pleurotus pulmonarius: Structure and antinociceptive effect. En: Phytochemistry. 2008, vol. 69, p.2731–2736. Disponible en: https://doi.org/10.1016/j.phytochem.2008.08.006SMIDERLE, Fhernanda R, et al. Anti-inflammatory and analgesic properties in a rodent model of a (1-->3), (1-->6)-linked beta-glucan isolated from Pleurotus pulmonarius. En: European Journal of Pharmacology. 2008, vol. 597, no. 1–3, p. 86–91. Disponible en: https://doi.org/10.1016/j.ejphar.2008.08.028SMITH, JF; LÓPEZ MARTÍNEZ, de Alva, MARTÍNEZ CARRERA, Daniel. La producción comercial de hongos comestibles en Bolivia y Colombia. En: MARTÍNEZ-CARRERA, Daniel, et al. Hacia un Desarrollo sustentable de Producción-Consumo de los Hongos Comestibles y Medicinales en Latinoamérica: Avances y Perspectivas en el siglo XXI. Puebla: Red Latinoamericana de Hongos Comestibles y Medicinales-COLPOS-UNSCONACYT-AMC-UAEMUPAEP-IMINAP, 2010. p. 425–436. ISBN 970-9752-01-4.SMITH, Roger M. Before the injection - Modern methods of sample preparation for separation techniques. En: Journal of Chromatography A. 2003, vol. 1000, no. 1–2, p. 3–27. Disponible en: https://doi.org/10.1016/S0021-9673(03)00511-9SOOD, Ankita y GUPTA, Mahesh. Extraction process optimization for bioactive compounds in pomegranate peel. En: Food Bioscience. 2015, vol. 12, p. 100–106 Disponible en: https://doi.org/10.1016/j.fbio.2015.09.004SUÁREZ ARANGO, Carolina y NIETO, Ivonne Jeannette. Cultivo biotecnológico de macrohongos comestibles: una alternativa en la obtención de nutracéuticos. En: Revista Iberoamericana de Micología. 2013, vol. 30, no. 1, p. 1–8. Disponible en: https://doi.org/10.1016/j.riam.2012.03.011SULISTIANY, Henny, et al. Production of Fruiting Body and Antioxidant Activity of Wild Pleurotus. En: HAYATI Journal of Biosciences, 2016, vol. 23, no. 4, p. 191–195. Disponible en: https://doi.org/10.1016/J.HJB.2016.07.003SUN, Wu Ping, et al. Comparison of the effects of nicotinic acid and nicotinamide degradation on plasma betaine and choline levels. En: Clinical Nutrition. 2017, vol, 36, no. 4, p. 1136–1142. Disponible en: https://doi.org/10.1016/j.clnu.2016.07.016SUN, Yongxu y LIU, Jicheng. Purification, structure and immunobiological activity of a water-soluble polysaccharide from the fruiting body of Pleurotus ostreatus. En: Bioresource Technology. 2009, vol. 100, no. 2, p. 983–986. Disponible en: https://doi.org/10.1016/j.biortech.2008.06.036SUN, Yongxu, et al. Technology optimization for polysaccharides (POP) extraction from the fruiting bodies of Pleurotus ostreatus by Box-Behnken statistical design. En: Carbohydrate Polymers. 2010, vol. 80, no. 1, p. 242–247. Disponible en: https://doi.org/10.1016/j.carbpol.2009.11.018SZWENGIEl, Artur y STACHOWIAK, Bárbara. Deproteinization of water-soluble ß-glucan during acid extraction from fruiting bodies of Pleurotus ostreatus mushrooms. En: Carbohydrate Polymers. 2016, vol. 146, p. 310–319. Disponible en: https://doi.org/10.1016/j.carbpol.2016.03.015SYNYTSYA, Andriy, et al. Glucans from fruit bodies of cultivated mushrooms Pleurotus ostreatus and Pleurotus eryngii: Structure and potential prebiotic activity. En: Carbohydrate Polymers. 2009, vol76, no.4, p. 548–556. Disponible en: http://doi.org/10.1016/j.carbpol.2008.11.021SYNYTSYA, Andriy y NOVÁK, Miroslav. Structural diversity of fungal glucans. En: Carbohydrate Polymers. 2013, vol. 92, no. 1, p. 792–809. Disponible en: https://doi.org/10.1016/j.carbpol.2012.09.077TAOFIQ, Oludemi, et al. Mushrooms extracts and compounds in cosmetics, cosmeceuticals and nutricosmetics-A review. En: Industrial Crops and Products. 2016, vol. 90, p. 38–48. Disponible en: https://doi.org/10.1016/j.indcrop.2016.06.012TAOFIQ, Oludemi, et al. UV-irradiated mushrooms as a source of vitamin D2: A review. En: Trends in Food Science & Technology. 2017, vol. 70, p. 82-74. Disponible en: https://doi.org/10.1016/j.tifs.2017.10.008TEHRANI, Mohammad Hassan Houshdar, et al. Search for Proteins in the Liquid Extract of Edible Mushroom, Agaricusbisporus, and Studying their Antibacterial Effects. En: Iran J Pharm Res. 2012 Winter, vol 11, p. 145–150.TERRY, Paul, et al. Fruit, vegetables, dietary fiber, and risk of colorectal cancer. En: Journal of the National Cancer Institute. 2001, vol. 93, no 7, pp. 525–533. Disponible en: https://doi.org/10.1093/jnci/93.7.525THORPE, Edgar y THORPE, Showick. The Pearson General Knowledge Manual. India: Pearson, 2010. p. B27. ISBN 978-81-317-2790-4.TONG, Haibin, et al. Structural characterization and in vitro antitumor activity of a novel polysaccharide isolated from the fruiting bodies of Pleurotus ostreatus. En: Bioresource Technology. 2009, vol. 100, no. 4, p. 1682–1686. Disponible en: https://doi.org/10.1016/j.biortech.2008.09.004TORRES-CABRA, Eneida; HERNÁNDEZ-FERNÁNDEZ, Javier y PÉREZ-RUBIANO, Claudia. Cuantificación de proteínas totales en extractos crudos de cepas nativas de Bacillus thuringiensis aisladas de Boyacá y Cundinamarca. En: Conexión Agropecuaria JDC. 2013, vol. 3, no. 2, p. 37–43. Disponible en: http://www.revistasjdc.com/main/index.php/conexagro/article/view/314UNEKWU, Hamzah Rabiat, et al. Phytochemical screening and antioxidant activity of methanolic extract of selected wild edible Nigerian mushrooms. En: Asian Pacific Journal of Tropical Disease. 2014, vol. 4, no. S1. Disponible en: https://doi.org/10.1016/S2222-1808(14)60431-XVALVERDE, Elizabeth y DOS SANTOS, Macedo. Extracción de materias primas vegetales. En: PINZÓN, Roberto. Fundamentos de Tecnología de Productos Fitoterapéuticos. Bogotá D.C.: Área de Ciencia y Tecnología del Convenio Andrés Bello & Red Iberoamericana de Productos Fitofarmacéuticos (RIPROFITO) del subprograma X del CYTED, 2000. p. 38. ISBN 9586980014.VALVERDE, María Elena; HERNÁNDEZ-PEREZ, Talía y PAREDES-LÓPEZ, Octavio. Edible mushrooms: improving human health and promoting quality life. En: Int J Microbiol. 2013, p. 1–14. Disponible en: https://doi.org/10.1155/2015/376387VAMANU, Emanuel. In vitro antioxidant and antimicrobial activities of two edible mushroom mycelia obtained in the presence of different nitrogen sources. En: Journal of Medicinal Food. 2013, vol. 16, no. 2, p. 155–166. Disponible en: https://doi.org/10.1089/jmf.2012.0030WANG, Hexiang; GAO, Jiquan y NG, T. B. A new lectin with highly potent antihepatoma and antisarcoma activities from the oyster mushroom Pleurotus ostreatus. En: Biochemical and biophysical research communications. 2000. Vol. 275, nol. 3, p. 810– 816. Disponible en: https://doi.org/10.1006/bbrc.2000.3373WANG, Hexiang X. y NG, T. B. Isolation of a novel ubiquitin-like protein from Pleurotus ostreatus mushroom with anti-human immunodeficiency virus, translation-inhibitory, and ribonuclease activities. En: Biochemical and biophysical research communications. 2000, vol. 276, no. 2, p. 587–593. Disponible en: https://doi.org/DOI 10.1006/bbrc.2000.3540WASSER, S. P. Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides. En: Appl Microbiol Biotechnol. 2002, Vol. 60, p. 258–274. Disponible en: https://doi.org/10.1007/s00253-002-1076-7WILDMAN, Robert E. C. y KELLEY, Mike. Nutraceutical and Functional Foods. En: Handbook of Nutraceuticals and Functional Foods. 2 ed. Boca Raton, Florida: Robert E. C. Wildman, 2007. p. 1–22. Disponible en: https://doi.org/10.1201/9781420006186XIA, Fengguo, et al. Antioxidant effects of a water-soluble proteoglycan isolated from the fruiting bodies of Pleurotus ostreatus. En: Journal of the Taiwan Institute of Chemical Engineers. 2011, vol. 42, no. 3, p. 402–407. Disponible en: https://doi.org/10.1016/j.jtice.2010.08.012XU, Xiaofei, et al. Bioactive proteins from mushrooms. En: Biotechnology Advances. 2011, vol. 29, no. 6, p. 667–674. Disponible en: https://doi.org/10.1016/j.biotechadv.2011.05.003YAN, Bingju; JING, Liying y WANG, Jun. A polysaccharide (PNPA) from Pleurotus nebrodensis offers cardiac protection against ischemia–reperfusion injury in rats. En: Carbohydr Polym. 2015, vol. 133, p. 1–7. Disponible en: https://doi.org/10.1016/j.carbpol.2015.06.076YANG, Qi, et al. Gastroprotective activities of a polysaccharide from the fruiting bodies of Pleurotus ostreatus in rats. En: International Journal of Biological Macromolecules. 2012, vol. 50, no. 5, p. 1224–1228. Disponible en: https://doi.org/10.1016/j.ijbiomac.2012.03.020YONG NAM, Sang y MOO LEE, Young. Pervaporation separation of methanol/methyl tbutyl ether through chitosan composite membrane modified with surfactants. En: Journal of Membrane Science. 1999, vol. 157, no. 1, p. 63–71. https://doi.org/10.1016/S0376-7388(98)00368-8YOSHIOKA, Yûko, et al. Antitumor polysaccharides from P. ostreatus (Fr.) quél.: Isolation and structure of a β-glucan. En: Carbohydrate Research. 1985, vol. 140, no. 1, p. 93– 100. Disponible en: https://doi.org/10.1016/0008-6215(85)85052-7YUSEF, Hasan M., THRELFALL, D. R. y GOODWIN, T. W. Some lipids of the oidia of Pleurotus ostreatus. En: Phytochemistry. 1965, vol. 4, no. 4, p. 559–562. Disponible en: https://doi.org/10.1016/S0031-9422(00)86216-0ZEKOVIĆ, Djordje B, et al. Natural and Modified (1→3)-β-D-Glucans in Health Promotion and Disease Alleviation. En: Critical Reviews in Biotechnology. 2005, vol. 25, no. 4, p. 205–230. Disponible en: https://doi.org/10.1080/07388550500376166ZERVAKIS, Georgios y BALIS, Constantinos. A pluralistic approach in the study of Pleurotus species with emphasis on compatibility and physiology of the European morphotaxa. En: Mycological Research. 1996, vol. 100, no. 6, p. 717–731. Disponible en: https://doi.org/10.1016/S0953-7562(96)80205-XZHANG, Chen, et al. Antioxidant and hepatoprotective activities of intracellular polysaccharide from Pleurotus eryngii SI-04. En: Int J Biol Macromol. 2016, vol. 91, p. 568–577. Disponible en: https://doi.org/10.1016/j.ijbiomac.2016.05.104ZHANG, Chengdong, et al. Edible fungus degrade bisphenol A with no harmful effect on its fatty acid composition. En: Ecotoxicology and Environmental Safety. 2015, vol. 118, p. 126–132. Disponible en: https://doi.org/10.1016/j.ecoenv.2015.04.020ZHANG, Jie, et al. Antitumor polysaccharides from a Chinese mushroom, “yuhuangmo,” the fruiting body of Pleurotus citrinopileatus. En: Bioscience, biotechnology, and biochemistry. 1994, vol. 58, no. 7, p. 1195–1201. Disponible en: https://doi.org/10.1271/bbb.58.1195ZHANG, Yan, et al. Antidiabetic effect of polysaccharides from Pleurotus ostreatus in streptozotocin-induced diabetic rats. En: International Journal of Biological Macromolecules. 2016, vol. 83, p. 126–132. Disponible en: https://doi.org/10.1016/j.ijbiomac.2015.11.045ZHANG, Yan, et al. Polysaccharides from Pleurotus ostreatus alleviate cognitive impairment in a rat model of Alzheimer’s disease. En: International Journal of Biological Macromolecules. 2016, vol. 92, p. 935–941. Disponible en: https://doi.org/10.1016/j.ijbiomac.2016.08.008ZHANG, Yan et al. Regulating dyslipidemia effect of polysaccharides from Pleurotus ostreatus on fat-emulsion-induced hyperlipidemia rats. En: International Journal of Biological Macromolecules. 2017, vol. 101, p. 107–116. Disponible en: https://doi.org/10.1016/J.IJBIOMAC.2017.03.084ZHANG, Weimin, et al. Feeding with supplemental squalene enhances the productive performance in boars. En: Animal Reproduction Science. 2008, vol. 104, no. 2–4, p. 445–449. Disponible en: https://doi.org/10.1016/j.anireprosci.2007.08.003ZHANG, Yunxia, et al. Characterization and in vitro antioxidant activities of polysaccharides from Pleurotus ostreatus. En: International Journal of Biological Macromolecules. 2012, vol. 51, no. 3, p. 259–265. Disponible en: https://doi.org/10.1016/j.ijbiomac.2012.05.003ZHU, Fengmei, et al. Beta-glucans from edible and medicinal mushrooms: Characteristics, physicochemical and biological activities. En: Journal of Food Composition and Analysis. 2015, vol. 41, p. 165–173. Disponible en: https://doi.org/10.1016/j.jfca.2015.01.019N/AMaceraciónExtracciónOptimizaciónPleurotusSustancias bioactivasMacerationExtractionOptimizationBioactive substancesPublicationORIGINAL1121909485_53931006.pdf1121909485_53931006.pdfTrabajo de gradoapplication/pdf2465105https://dspace7-unillanos.metacatalogo.org/bitstreams/b173591d-213d-4578-8e25-598240f17e0b/download031fd282a5584ef4467357258c6619d0MD51Anexo 1.pdfAnexo 1.pdfCarta de autorizaciónapplication/pdf495078https://dspace7-unillanos.metacatalogo.org/bitstreams/11fe1979-0b24-44f5-9e02-3d70dc94d5ea/downloadd0829f1f2ca46a455887b93ce347aa5cMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-814775https://dspace7-unillanos.metacatalogo.org/bitstreams/447697c7-7cc4-4734-9e78-ee02601285d2/downloadf661acf14bedbf9f5d13897a0387e751MD53TEXT1121909485_53931006.pdf.txt1121909485_53931006.pdf.txtExtracted texttext/plain290475https://dspace7-unillanos.metacatalogo.org/bitstreams/938935c3-8411-44ee-8923-d8416c1aea10/downloadf4da2b5d9aded2295c4131ed3e0e2bb0MD54Anexo 1.pdf.txtAnexo 1.pdf.txtExtracted texttext/plain2https://dspace7-unillanos.metacatalogo.org/bitstreams/4c098ff3-afac-4c83-8b6a-6d237e839533/downloade1c06d85ae7b8b032bef47e42e4c08f9MD56THUMBNAIL1121909485_53931006.pdf.jpg1121909485_53931006.pdf.jpgGenerated Thumbnailimage/jpeg5994https://dspace7-unillanos.metacatalogo.org/bitstreams/80cf96e4-dae4-4f4f-a078-6499e2b1aba6/downloade9fb06ea87d9ba27e9185df0c92073cdMD55Anexo 1.pdf.jpgAnexo 1.pdf.jpgGenerated Thumbnailimage/jpeg12506https://dspace7-unillanos.metacatalogo.org/bitstreams/b4c4f66c-474e-40f0-941e-dde607fb7605/download60568eb98b8482e5234ef28f7c874a4fMD57001/2939oai:dspace7-unillanos.metacatalogo.org:001/29392024-04-17 16:38:06.433https://creativecommons.org/licenses/by-nc-nd/4.0/Derechos Reservados - Universidad de los Llanos, 2018open.accesshttps://dspace7-unillanos.metacatalogo.orgRepositorio Universidad de Los Llanosrepositorio@unillanos.edu.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 |