COVID-19-activated SREBP2 disturbs cholesterol biosynthesis and leads to cytokine storm

Sterol regulatory element binding protein-2 (SREBP-2) is activated by cytokines or pathogen, such as virus or bacteria, but its association with diminished cholesterol levels in COVID-19 patients is unknown. Here, we evaluated SREBP-2 activation in peripheral blood mononuclear cells of COVID-19 pati...

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Autores:

Tipo de recurso:

Article of investigation

Fecha de publicación:

2020

Institución:

Universidad de Bogotá Jorge Tadeo Lozano

Repositorio:

Expeditio: repositorio UTadeo

Idioma:

eng

OAI Identifier:

oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/14042

Acceso en línea:

https://doi.org/10.1038/s41392-020-00292-7
http://hdl.handle.net/20.500.12010/14042

Palabra clave:

COVID-19-activated
SREBP2
Cholesterol biosynthesis
Cytokine storm
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus

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