Subcellular hot spots of GPCR signaling promote vascular inflammation
G-coupled protein receptors (GPCRs) comprise the largest class of druggable targets. Signaling by GPCRs is initiated from subcellular hot spots including the plasma membrane, signalosomes and endosomes to contribute to vascular inflammation. GPCR-G protein signaling at the plasma membrane causes end...
- Autores:
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2020
- Institución:
- Universidad de Bogotá Jorge Tadeo Lozano
- Repositorio:
- Expeditio: repositorio UTadeo
- Idioma:
- eng
- OAI Identifier:
- oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/12479
- Acceso en línea:
- https://doi.org/10.1016/j.coemr.2020.07.011
http://hdl.handle.net/20.500.12010/12479
- Palabra clave:
- Arrestins
COVID-19
Endosomes
Endothelial
MALT1
JAK-STAT
NFκB
p38 MAPK
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
- Rights
- License
- Acceso restringido
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oai_identifier_str |
oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/12479 |
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network_name_str |
Expeditio: repositorio UTadeo |
repository_id_str |
|
dc.title.spa.fl_str_mv |
Subcellular hot spots of GPCR signaling promote vascular inflammation |
title |
Subcellular hot spots of GPCR signaling promote vascular inflammation |
spellingShingle |
Subcellular hot spots of GPCR signaling promote vascular inflammation Arrestins COVID-19 Endosomes Endothelial MALT1 JAK-STAT NFκB p38 MAPK Síndrome respiratorio agudo grave COVID-19 SARS-CoV-2 Coronavirus |
title_short |
Subcellular hot spots of GPCR signaling promote vascular inflammation |
title_full |
Subcellular hot spots of GPCR signaling promote vascular inflammation |
title_fullStr |
Subcellular hot spots of GPCR signaling promote vascular inflammation |
title_full_unstemmed |
Subcellular hot spots of GPCR signaling promote vascular inflammation |
title_sort |
Subcellular hot spots of GPCR signaling promote vascular inflammation |
dc.subject.spa.fl_str_mv |
Arrestins COVID-19 Endosomes Endothelial MALT1 JAK-STAT NFκB p38 MAPK |
topic |
Arrestins COVID-19 Endosomes Endothelial MALT1 JAK-STAT NFκB p38 MAPK Síndrome respiratorio agudo grave COVID-19 SARS-CoV-2 Coronavirus |
dc.subject.lemb.spa.fl_str_mv |
Síndrome respiratorio agudo grave COVID-19 SARS-CoV-2 Coronavirus |
description |
G-coupled protein receptors (GPCRs) comprise the largest class of druggable targets. Signaling by GPCRs is initiated from subcellular hot spots including the plasma membrane, signalosomes and endosomes to contribute to vascular inflammation. GPCR-G protein signaling at the plasma membrane causes endothelial barrier disruption and also cross-talks with growth factor receptors to promote proinflammatory signaling. A second surge of GPCR signaling is initiated by cytoplasmic NFκB activation mediated by β-arrestins and CARMA-Bcl10-MALT1 signalosomes. Once internalized, ubiquitinated GPCRs initiate signaling from endosomes via assembly of the transforming growth factor-β-activated kinase binding protein-1 (TAB1)-TAB2-p38 MAPK complex to promote vascular inflammation. Understanding the complexities of GPCR signaling is critical for development of new strategies to treat vascular inflammation such as that associated with COVID-19. |
publishDate |
2020 |
dc.date.accessioned.none.fl_str_mv |
2020-08-31T17:51:19Z |
dc.date.available.none.fl_str_mv |
2020-08-31T17:51:19Z |
dc.date.created.none.fl_str_mv |
2020 |
dc.type.local.spa.fl_str_mv |
Artículo |
dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
format |
http://purl.org/coar/resource_type/c_2df8fbb1 |
dc.identifier.issn.spa.fl_str_mv |
2451-9650 |
dc.identifier.other.spa.fl_str_mv |
https://doi.org/10.1016/j.coemr.2020.07.011 |
dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/20.500.12010/12479 |
dc.identifier.doi.spa.fl_str_mv |
https://doi.org/10.1016/j.coemr.2020.07.011 |
identifier_str_mv |
2451-9650 |
url |
https://doi.org/10.1016/j.coemr.2020.07.011 http://hdl.handle.net/20.500.12010/12479 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_f1cf |
dc.rights.local.spa.fl_str_mv |
Acceso restringido |
rights_invalid_str_mv |
Acceso restringido http://purl.org/coar/access_right/c_f1cf |
dc.format.extent.spa.fl_str_mv |
19 páginas |
dc.format.mimetype.spa.fl_str_mv |
image/jepg |
dc.publisher.spa.fl_str_mv |
Current Opinion in Endocrine and Metabolic Research |
dc.source.spa.fl_str_mv |
reponame:Expeditio Repositorio Institucional UJTL instname:Universidad de Bogotá Jorge Tadeo Lozano |
instname_str |
Universidad de Bogotá Jorge Tadeo Lozano |
institution |
Universidad de Bogotá Jorge Tadeo Lozano |
reponame_str |
Expeditio Repositorio Institucional UJTL |
collection |
Expeditio Repositorio Institucional UJTL |
bitstream.url.fl_str_mv |
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bitstream.checksum.fl_str_mv |
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repository.name.fl_str_mv |
Repositorio Institucional - Universidad Jorge Tadeo Lozano |
repository.mail.fl_str_mv |
expeditio@utadeo.edu.co |
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spelling |
2020-08-31T17:51:19Z2020-08-31T17:51:19Z20202451-9650https://doi.org/10.1016/j.coemr.2020.07.011http://hdl.handle.net/20.500.12010/12479https://doi.org/10.1016/j.coemr.2020.07.011G-coupled protein receptors (GPCRs) comprise the largest class of druggable targets. Signaling by GPCRs is initiated from subcellular hot spots including the plasma membrane, signalosomes and endosomes to contribute to vascular inflammation. GPCR-G protein signaling at the plasma membrane causes endothelial barrier disruption and also cross-talks with growth factor receptors to promote proinflammatory signaling. A second surge of GPCR signaling is initiated by cytoplasmic NFκB activation mediated by β-arrestins and CARMA-Bcl10-MALT1 signalosomes. Once internalized, ubiquitinated GPCRs initiate signaling from endosomes via assembly of the transforming growth factor-β-activated kinase binding protein-1 (TAB1)-TAB2-p38 MAPK complex to promote vascular inflammation. Understanding the complexities of GPCR signaling is critical for development of new strategies to treat vascular inflammation such as that associated with COVID-19.19 páginasimage/jepgengCurrent Opinion in Endocrine and Metabolic Researchreponame:Expeditio Repositorio Institucional UJTLinstname:Universidad de Bogotá Jorge Tadeo LozanoArrestinsCOVID-19EndosomesEndothelialMALT1JAK-STATNFκBp38 MAPKSíndrome respiratorio agudo graveCOVID-19SARS-CoV-2CoronavirusSubcellular hot spots of GPCR signaling promote vascular inflammationArtículohttp://purl.org/coar/resource_type/c_2df8fbb1Acceso restringidohttp://purl.org/coar/access_right/c_f1cfBirch, Cierra A.Molinar-Inglis, OliviaTrejo, JoAnnTHUMBNAILCaptura.PNGCaptura.PNGPortadaimage/png93716https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12479/4/Captura.PNG054e6cba1905733e05de3911999d5ff0MD54open accessSubcellular-hot-spots-of-GPCR-signaling-p_2020_Current-Opinion-in-Endocrine-.pdf.jpgSubcellular-hot-spots-of-GPCR-signaling-p_2020_Current-Opinion-in-Endocrine-.pdf.jpgIM Thumbnailimage/jpeg11237https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12479/5/Subcellular-hot-spots-of-GPCR-signaling-p_2020_Current-Opinion-in-Endocrine-.pdf.jpg4901a0329ced6e1a45858c081f1f441fMD55open accessORIGINALCaptura.PNGCaptura.PNGVer portadaimage/png93716https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12479/1/Captura.PNG054e6cba1905733e05de3911999d5ff0MD51open accessSubcellular-hot-spots-of-GPCR-signaling-p_2020_Current-Opinion-in-Endocrine-.pdfSubcellular-hot-spots-of-GPCR-signaling-p_2020_Current-Opinion-in-Endocrine-.pdfArtículo reservadoapplication/pdf1854853https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12479/3/Subcellular-hot-spots-of-GPCR-signaling-p_2020_Current-Opinion-in-Endocrine-.pdffeb7a8ac118fd63fab896d2dbc7a2b21MD53embargoed access|||2200-08-31LICENSElicense.txtlicense.txttext/plain; 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