Subcellular hot spots of GPCR signaling promote vascular inflammation

G-coupled protein receptors (GPCRs) comprise the largest class of druggable targets. Signaling by GPCRs is initiated from subcellular hot spots including the plasma membrane, signalosomes and endosomes to contribute to vascular inflammation. GPCR-G protein signaling at the plasma membrane causes end...

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Autores:
Tipo de recurso:
Article of investigation
Fecha de publicación:
2020
Institución:
Universidad de Bogotá Jorge Tadeo Lozano
Repositorio:
Expeditio: repositorio UTadeo
Idioma:
eng
OAI Identifier:
oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/12479
Acceso en línea:
https://doi.org/10.1016/j.coemr.2020.07.011
http://hdl.handle.net/20.500.12010/12479
Palabra clave:
Arrestins
COVID-19
Endosomes
Endothelial
MALT1
JAK-STAT
NFκB
p38 MAPK
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
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Acceso restringido