SARS-CoV2-mediated suppression of NRF2- signaling reveals potent antiviral and anti- inflammatory activity of 4-octyl-itaconate and dimethyl fumarate
Antiviral strategies to inhibit Severe Acute Respiratory Syndrome Coronavirus 2 (SARSCoV2) and the pathogenic consequences of COVID-19 are urgently required. Here, we demonstrate that the NRF2 antioxidant gene expression pathway is suppressed in biopsies obtained from COVID-19 patients. Further, we...
- Autores:
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2020
- Institución:
- Universidad de Bogotá Jorge Tadeo Lozano
- Repositorio:
- Expeditio: repositorio UTadeo
- Idioma:
- eng
- OAI Identifier:
- oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/14430
- Acceso en línea:
- https://doi.org/10.1038/s41467-020-18764-3
http://hdl.handle.net/20.500.12010/14430
- Palabra clave:
- SARS-CoV2
NRF2- signaling
4-octyl-itaconate
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
- Rights
- License
- Abierto (Texto Completo)