Genetic lesions of type i interferon signalling in human antiviral immunity

The concept that type I interferons (IFN-I) are essential to antiviral immunity derives from studies on animal models and cell lines. Virtually all pathogenic viruses have evolved countermeasures to IFN-I restriction, and genetic loss of viral IFN-I antagonists leads to virus attenuation. But just h...

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Autores:
Tipo de recurso:
Article of investigation
Fecha de publicación:
2020
Institución:
Universidad de Bogotá Jorge Tadeo Lozano
Repositorio:
Expeditio: repositorio UTadeo
Idioma:
eng
OAI Identifier:
oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/13831
Acceso en línea:
https://doi.org/10.1016/j.tig.2020.08.017
http://hdl.handle.net/20.500.12010/13831
Palabra clave:
Human antiviral immunity
Genetic lesions
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
Rights
License
Abierto (Texto Completo)
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dc.title.spa.fl_str_mv Genetic lesions of type i interferon signalling in human antiviral immunity
title Genetic lesions of type i interferon signalling in human antiviral immunity
spellingShingle Genetic lesions of type i interferon signalling in human antiviral immunity
Human antiviral immunity
Genetic lesions
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
title_short Genetic lesions of type i interferon signalling in human antiviral immunity
title_full Genetic lesions of type i interferon signalling in human antiviral immunity
title_fullStr Genetic lesions of type i interferon signalling in human antiviral immunity
title_full_unstemmed Genetic lesions of type i interferon signalling in human antiviral immunity
title_sort Genetic lesions of type i interferon signalling in human antiviral immunity
dc.subject.spa.fl_str_mv Human antiviral immunity
Genetic lesions
topic Human antiviral immunity
Genetic lesions
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
dc.subject.lemb.spa.fl_str_mv Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
description The concept that type I interferons (IFN-I) are essential to antiviral immunity derives from studies on animal models and cell lines. Virtually all pathogenic viruses have evolved countermeasures to IFN-I restriction, and genetic loss of viral IFN-I antagonists leads to virus attenuation. But just how important is IFN-I to antiviral defence in humans? The recent discovery of genetic defects of IFN-I signalling illuminates this and other questions of IFN biology, including the role of the mucosa-restricted type III IFNs (IFN-III), informing our understanding of the place of the IFN system within the concerted antiviral response. Here we review monogenic lesions of IFN-I signalling pathways and summarise the organising principles which emerge.
publishDate 2020
dc.date.accessioned.none.fl_str_mv 2020-09-25T20:38:12Z
dc.date.available.none.fl_str_mv 2020-09-25T20:38:12Z
dc.date.created.none.fl_str_mv 2020
dc.type.local.spa.fl_str_mv Artículo
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
format http://purl.org/coar/resource_type/c_2df8fbb1
dc.identifier.issn.spa.fl_str_mv 1362-4555
dc.identifier.other.spa.fl_str_mv https://doi.org/10.1016/j.tig.2020.08.017
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12010/13831
dc.identifier.doi.spa.fl_str_mv https://doi.org/10.1016/j.tig.2020.08.017
identifier_str_mv 1362-4555
url https://doi.org/10.1016/j.tig.2020.08.017
http://hdl.handle.net/20.500.12010/13831
dc.language.iso.spa.fl_str_mv eng
language eng
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.local.spa.fl_str_mv Abierto (Texto Completo)
rights_invalid_str_mv Abierto (Texto Completo)
http://purl.org/coar/access_right/c_abf2
dc.format.extent.spa.fl_str_mv 13 páginas
dc.format.mimetype.spa.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Trends in genetics
dc.source.spa.fl_str_mv reponame:Expeditio Repositorio Institucional UJTL
instname:Universidad de Bogotá Jorge Tadeo Lozano
instname_str Universidad de Bogotá Jorge Tadeo Lozano
institution Universidad de Bogotá Jorge Tadeo Lozano
reponame_str Expeditio Repositorio Institucional UJTL
collection Expeditio Repositorio Institucional UJTL
bitstream.url.fl_str_mv https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/13831/2/license.txt
https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/13831/3/Genetic-Lesions-of-Type-I-Interferon-Signalling-in-Human-_2020_Trends-in-Gen.pdf.jpg
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spelling 2020-09-25T20:38:12Z2020-09-25T20:38:12Z20201362-4555https://doi.org/10.1016/j.tig.2020.08.017http://hdl.handle.net/20.500.12010/13831https://doi.org/10.1016/j.tig.2020.08.017The concept that type I interferons (IFN-I) are essential to antiviral immunity derives from studies on animal models and cell lines. Virtually all pathogenic viruses have evolved countermeasures to IFN-I restriction, and genetic loss of viral IFN-I antagonists leads to virus attenuation. But just how important is IFN-I to antiviral defence in humans? The recent discovery of genetic defects of IFN-I signalling illuminates this and other questions of IFN biology, including the role of the mucosa-restricted type III IFNs (IFN-III), informing our understanding of the place of the IFN system within the concerted antiviral response. Here we review monogenic lesions of IFN-I signalling pathways and summarise the organising principles which emerge.13 páginasapplication/pdfengTrends in geneticsreponame:Expeditio Repositorio Institucional UJTLinstname:Universidad de Bogotá Jorge Tadeo LozanoHuman antiviral immunityGenetic lesionsSíndrome respiratorio agudo graveCOVID-19SARS-CoV-2CoronavirusGenetic lesions of type i interferon signalling in human antiviral immunityArtículohttp://purl.org/coar/resource_type/c_2df8fbb1Abierto (Texto Completo)http://purl.org/coar/access_right/c_abf2Duncan, Christopher J.A.Randall, Richard E.Hambleton, SophieLICENSElicense.txtlicense.txttext/plain; charset=utf-82938https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/13831/2/license.txtabceeb1c943c50d3343516f9dbfc110fMD52open accessTHUMBNAILGenetic-Lesions-of-Type-I-Interferon-Signalling-in-Human-_2020_Trends-in-Gen.pdf.jpgGenetic-Lesions-of-Type-I-Interferon-Signalling-in-Human-_2020_Trends-in-Gen.pdf.jpgIM Thumbnailimage/jpeg24605https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/13831/3/Genetic-Lesions-of-Type-I-Interferon-Signalling-in-Human-_2020_Trends-in-Gen.pdf.jpg6e09655033aca335a4c4e52d2acb0bc8MD53open access20.500.12010/13831oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/138312021-03-17 20:26:22.646metadata only accessRepositorio Institucional - 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