Genetic lesions of type i interferon signalling in human antiviral immunity

The concept that type I interferons (IFN-I) are essential to antiviral immunity derives from studies on animal models and cell lines. Virtually all pathogenic viruses have evolved countermeasures to IFN-I restriction, and genetic loss of viral IFN-I antagonists leads to virus attenuation. But just h...

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Autores:
Tipo de recurso:
Article of investigation
Fecha de publicación:
2020
Institución:
Universidad de Bogotá Jorge Tadeo Lozano
Repositorio:
Expeditio: repositorio UTadeo
Idioma:
eng
OAI Identifier:
oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/13831
Acceso en línea:
https://doi.org/10.1016/j.tig.2020.08.017
http://hdl.handle.net/20.500.12010/13831
Palabra clave:
Human antiviral immunity
Genetic lesions
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
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