Higher binding affinity of Furin to SARS-CoV-2 spike (S) protein D614G could be associated with higher SARS-CoV-2 infectivity

Objective The coronavirus disease-19 (COVID-19) pandemic has caused an exponential rise in death rates and hospitalizations. The aim of this study was to characterize the D614G mutation of SARS-CoV-2 S-protein, which may affect viral infectivity. Methods The effect of D614G mutation on the structure...

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Autores:

Tipo de recurso:

Article of investigation

Fecha de publicación:

2020

Institución:

Universidad de Bogotá Jorge Tadeo Lozano

Repositorio:

Expeditio: repositorio UTadeo

Idioma:

eng

OAI Identifier:

oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/14761

Acceso en línea:

https://doi.org/10.1016/j.ijid.2020.10.033
http://hdl.handle.net/20.500.12010/14761

Palabra clave:

SARS-CoV-2
COVID-19
Furin
S-protein
G clade
Interatomic binding
Thermodynamic stability
Molecular dynamic simulations
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus

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