The role of furin cleavage site in SARS-CoV-2 spike protein-mediated membrane fusion in the presence or absence of trypsin

Dear Editor, The rapid spread of SARS-CoV-2 (also known as 2019-nCoV and HCoV-191), a novel lineage B betacoronavirus (βCoV), has caused a global pandemic of coronavirus disease (COVID-19). It has been speculated that RRAR, a unique furin-like cleavage site (FCS) in the spike protein (S), which is a...

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Tipo de recurso:: Article of journal

Fecha de publicación:: 2020

Institución:: Universidad de Bogotá Jorge Tadeo Lozano

Repositorio:: Expeditio: repositorio UTadeo

Idioma:: eng

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dc.title.spa.fl_str_mv	The role of furin cleavage site in SARS-CoV-2 spike protein-mediated membrane fusion in the presence or absence of trypsin
title	The role of furin cleavage site in SARS-CoV-2 spike protein-mediated membrane fusion in the presence or absence of trypsin
spellingShingle	The role of furin cleavage site in SARS-CoV-2 spike protein-mediated membrane fusion in the presence or absence of trypsin trypsin HCoV-191 betacoronavirus (βCoV) transmissibility Síndrome respiratorio agudo grave COVID-19 SARS-CoV-2 Coronavirus
title_short	The role of furin cleavage site in SARS-CoV-2 spike protein-mediated membrane fusion in the presence or absence of trypsin
title_full	The role of furin cleavage site in SARS-CoV-2 spike protein-mediated membrane fusion in the presence or absence of trypsin
title_fullStr	The role of furin cleavage site in SARS-CoV-2 spike protein-mediated membrane fusion in the presence or absence of trypsin
title_full_unstemmed	The role of furin cleavage site in SARS-CoV-2 spike protein-mediated membrane fusion in the presence or absence of trypsin
title_sort	The role of furin cleavage site in SARS-CoV-2 spike protein-mediated membrane fusion in the presence or absence of trypsin
dc.subject.spa.fl_str_mv	trypsin HCoV-191 betacoronavirus (βCoV) transmissibility
topic	trypsin HCoV-191 betacoronavirus (βCoV) transmissibility Síndrome respiratorio agudo grave COVID-19 SARS-CoV-2 Coronavirus
dc.subject.lemb.spa.fl_str_mv	Síndrome respiratorio agudo grave COVID-19 SARS-CoV-2 Coronavirus
description	Dear Editor, The rapid spread of SARS-CoV-2 (also known as 2019-nCoV and HCoV-191), a novel lineage B betacoronavirus (βCoV), has caused a global pandemic of coronavirus disease (COVID-19). It has been speculated that RRAR, a unique furin-like cleavage site (FCS) in the spike protein (S), which is absent in other lineage B βCoVs, such as SARS-CoV, is responsible for its high infectivity and transmissibility.2
publishDate	2020
dc.date.accessioned.none.fl_str_mv	2020-09-04T14:03:44Z
dc.date.available.none.fl_str_mv	2020-09-04T14:03:44Z
dc.date.created.none.fl_str_mv	2020
dc.type.local.spa.fl_str_mv	Artículo
dc.type.coar.spa.fl_str_mv	http://purl.org/coar/resource_type/c_6501
format	http://purl.org/coar/resource_type/c_6501
dc.identifier.issn.spa.fl_str_mv	2059-3635
dc.identifier.other.spa.fl_str_mv	https://www.nature.com/articles/s41392-020-0184-0
dc.identifier.uri.none.fl_str_mv	http://hdl.handle.net/20.500.12010/12692
dc.identifier.doi.spa.fl_str_mv	https://doi.org/10.1038/s41392-020-0184-0
identifier_str_mv	2059-3635
url	https://www.nature.com/articles/s41392-020-0184-0 http://hdl.handle.net/20.500.12010/12692 https://doi.org/10.1038/s41392-020-0184-0
dc.language.iso.spa.fl_str_mv	eng
language	eng
dc.rights.coar.fl_str_mv	http://purl.org/coar/access_right/c_16ec
dc.rights.local.spa.fl_str_mv	Acceso restringido
rights_invalid_str_mv	Acceso restringido http://purl.org/coar/access_right/c_16ec
dc.format.extent.spa.fl_str_mv	3 páginas
dc.format.mimetype.spa.fl_str_mv	application/pdf
dc.publisher.spa.fl_str_mv	signal transduction and targeted therapy
dc.source.spa.fl_str_mv	reponame:Expeditio Repositorio Institucional UJTL instname:Universidad de Bogotá Jorge Tadeo Lozano
instname_str	Universidad de Bogotá Jorge Tadeo Lozano
institution	Universidad de Bogotá Jorge Tadeo Lozano
reponame_str	Expeditio Repositorio Institucional UJTL
collection	Expeditio Repositorio Institucional UJTL
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repository.name.fl_str_mv	Repositorio Institucional - Universidad Jorge Tadeo Lozano
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spelling	2020-09-04T14:03:44Z2020-09-04T14:03:44Z20202059-3635https://www.nature.com/articles/s41392-020-0184-0http://hdl.handle.net/20.500.12010/12692https://doi.org/10.1038/s41392-020-0184-03 páginasapplication/pdfengsignal transduction and targeted therapyreponame:Expeditio Repositorio Institucional UJTLinstname:Universidad de Bogotá Jorge Tadeo LozanotrypsinHCoV-191betacoronavirus (βCoV)transmissibilitySíndrome respiratorio agudo graveCOVID-19SARS-CoV-2CoronavirusThe role of furin cleavage site in SARS-CoV-2 spike protein-mediated membrane fusion in the presence or absence of trypsinArtículohttp://purl.org/coar/resource_type/c_6501Acceso restringidohttp://purl.org/coar/access_right/c_16ecDear Editor, The rapid spread of SARS-CoV-2 (also known as 2019-nCoV and HCoV-191), a novel lineage B betacoronavirus (βCoV), has caused a global pandemic of coronavirus disease (COVID-19). It has been speculated that RRAR, a unique furin-like cleavage site (FCS) in the spike protein (S), which is absent in other lineage B βCoVs, such as SARS-CoV, is responsible for its high infectivity and transmissibility.2Xia, ShuaiLan, QiaoshuaiSu, ShanWang, XinlingXu, WeiLiu, ZezhongZhu, YunWang, QianLu, LuJiang, ShiboLICENSElicense.txtlicense.txttext/plain; charset=utf-82938https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12692/2/license.txtabceeb1c943c50d3343516f9dbfc110fMD52open accessTHUMBNAILThe role of furin cleavage site in SARS-CoV-2 spike protein-mediated membrane fusion in the presence or absence of trypsin.pngThe role of furin cleavage site in SARS-CoV-2 spike protein-mediated membrane fusion in the presence or absence of trypsin.pngimage/png110588https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12692/4/The%20role%20of%20furin%20cleavage%20site%20in%20SARS-CoV-2%20spike%20protein-mediated%20membrane%20fusion%20in%20the%20presence%20or%20absence%20of%20trypsin.png17788c77b64b7a070a611897a866d309MD54open accessThe role of furin cleavage site in SARS-CoV-2 spike protein-mediated membrane fusion in the presence or absence of trypsin.pdf.jpgThe role of furin cleavage site in SARS-CoV-2 spike protein-mediated membrane fusion in the presence or absence of trypsin.pdf.jpgIM Thumbnailimage/jpeg25362https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12692/5/The%20role%20of%20furin%20cleavage%20site%20in%20SARS-CoV-2%20spike%20protein-mediated%20membrane%20fusion%20in%20the%20presence%20or%20absence%20of%20trypsin.pdf.jpga05356a73b7c0eba9837320bcacd1185MD55open accessORIGINALThe role of furin cleavage site in SARS-CoV-2 spike protein-mediated membrane fusion in the presence or absence of trypsin.pdfThe role of furin cleavage site in SARS-CoV-2 spike protein-mediated membrane fusion in the presence or absence of trypsin.pdfDocumento Reservadoapplication/pdf1518277https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12692/3/The%20role%20of%20furin%20cleavage%20site%20in%20SARS-CoV-2%20spike%20protein-mediated%20membrane%20fusion%20in%20the%20presence%20or%20absence%20of%20trypsin.pdff990d5fa51cdd0781faf354b9c2dafe8MD53embargoed access\|\|\|2420-09-0420.500.12010/12692oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/126922020-09-04 09:05:27.807embargoed access\|\|\|2420-09-04Repositorio Institucional - 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The role of furin cleavage site in SARS-CoV-2 spike protein-mediated membrane fusion in the presence or absence of trypsin

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