The role of furin cleavage site in SARS-CoV-2 spike protein-mediated membrane fusion in the presence or absence of trypsin

Dear Editor, The rapid spread of SARS-CoV-2 (also known as 2019-nCoV and HCoV-191), a novel lineage B betacoronavirus (βCoV), has caused a global pandemic of coronavirus disease (COVID-19). It has been speculated that RRAR, a unique furin-like cleavage site (FCS) in the spike protein (S), which is a...

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Autores:
Tipo de recurso:
Article of journal
Fecha de publicación:
2020
Institución:
Universidad de Bogotá Jorge Tadeo Lozano
Repositorio:
Expeditio: repositorio UTadeo
Idioma:
eng
OAI Identifier:
oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/12692
Acceso en línea:
https://www.nature.com/articles/s41392-020-0184-0
http://hdl.handle.net/20.500.12010/12692
https://doi.org/10.1038/s41392-020-0184-0
Palabra clave:
trypsin
HCoV-191
betacoronavirus (βCoV)
transmissibility
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
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Acceso restringido