The YAP/TAZ Signaling Pathway in the Tumor Microenvironment and Carcinogenesis: Current Knowledge and Therapeutic Promises
The yes-associated protein (YAP) and the transcriptional coactivator with PDZ-binding motif (TAZ) are transcriptional coactivators, members of the Hippo signaling pathway, which play a critical role in cell growth regulation, embryonic development, regeneration, proliferation, and cancer origin and...
- Autores:
-
Ortega, Ángel
Vera, Ivana
Diaz, Maria P.
Navarro, Carla
Rojas, Milagros
Torres, Wheeler
Parra, Heliana
Salazar, Juan
De Sanctis, Juan B.
Bermúdez, Valmore
- Tipo de recurso:
- Fecha de publicación:
- 2022
- Institución:
- Universidad Simón Bolívar
- Repositorio:
- Repositorio Digital USB
- Idioma:
- eng
- OAI Identifier:
- oai:bonga.unisimon.edu.co:20.500.12442/9506
- Palabra clave:
- YAP/TAZ
Hippo signaling pathway
carcinogenesis
Tumor microenvironment
neoplastic stem cells
cell proliferation
drug resistance
chemoresistance
immunotherapy
- Rights
- openAccess
- License
- Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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The YAP/TAZ Signaling Pathway in the Tumor Microenvironment and Carcinogenesis: Current Knowledge and Therapeutic Promises |
| title |
The YAP/TAZ Signaling Pathway in the Tumor Microenvironment and Carcinogenesis: Current Knowledge and Therapeutic Promises |
| spellingShingle |
The YAP/TAZ Signaling Pathway in the Tumor Microenvironment and Carcinogenesis: Current Knowledge and Therapeutic Promises YAP/TAZ Hippo signaling pathway carcinogenesis Tumor microenvironment neoplastic stem cells cell proliferation drug resistance chemoresistance immunotherapy |
| title_short |
The YAP/TAZ Signaling Pathway in the Tumor Microenvironment and Carcinogenesis: Current Knowledge and Therapeutic Promises |
| title_full |
The YAP/TAZ Signaling Pathway in the Tumor Microenvironment and Carcinogenesis: Current Knowledge and Therapeutic Promises |
| title_fullStr |
The YAP/TAZ Signaling Pathway in the Tumor Microenvironment and Carcinogenesis: Current Knowledge and Therapeutic Promises |
| title_full_unstemmed |
The YAP/TAZ Signaling Pathway in the Tumor Microenvironment and Carcinogenesis: Current Knowledge and Therapeutic Promises |
| title_sort |
The YAP/TAZ Signaling Pathway in the Tumor Microenvironment and Carcinogenesis: Current Knowledge and Therapeutic Promises |
| dc.creator.fl_str_mv |
Ortega, Ángel Vera, Ivana Diaz, Maria P. Navarro, Carla Rojas, Milagros Torres, Wheeler Parra, Heliana Salazar, Juan De Sanctis, Juan B. Bermúdez, Valmore |
| dc.contributor.author.none.fl_str_mv |
Ortega, Ángel Vera, Ivana Diaz, Maria P. Navarro, Carla Rojas, Milagros Torres, Wheeler Parra, Heliana Salazar, Juan De Sanctis, Juan B. Bermúdez, Valmore |
| dc.subject.eng.fl_str_mv |
YAP/TAZ Hippo signaling pathway carcinogenesis Tumor microenvironment neoplastic stem cells cell proliferation drug resistance chemoresistance immunotherapy |
| topic |
YAP/TAZ Hippo signaling pathway carcinogenesis Tumor microenvironment neoplastic stem cells cell proliferation drug resistance chemoresistance immunotherapy |
| description |
The yes-associated protein (YAP) and the transcriptional coactivator with PDZ-binding motif (TAZ) are transcriptional coactivators, members of the Hippo signaling pathway, which play a critical role in cell growth regulation, embryonic development, regeneration, proliferation, and cancer origin and progression. The mechanism involves the nuclear binding of the un-phosphorylated YAP/TAZ complex to release the transcriptional enhanced associate domain (TEAD) from its repressors. The active ternary complex is responsible for the aforementioned biological effects. Overexpression of YAP/TAZ has been reported in cancer stem cells and tumor resistance. The resistance involves chemotherapy, targeted therapy, and immunotherapy. This review provides an overview of YAP/TAZ pathways’ role in carcinogenesis and tumor microenvironment. Potential therapeutic alternatives are also discussed. |
| publishDate |
2022 |
| dc.date.accessioned.none.fl_str_mv |
2022-04-01T18:28:42Z |
| dc.date.available.none.fl_str_mv |
2022-04-01T18:28:42Z |
| dc.date.issued.none.fl_str_mv |
2022 |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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info:eu-repo/semantics/article |
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Artículo científico |
| dc.identifier.citation.eng.fl_str_mv |
Ortega, Á.; Vera, I.; Diaz, M.P.; Navarro, C.; Rojas, M.; Torres, W.; Parra, H.; Salazar, J.; Sanctis, J.B.D.; Bermúdez, V. The YAP/TAZ Signaling Pathway in the Tumor Microenvironment and Carcinogenesis: Current Knowledge and Therapeutic Promises. Int. J. Mol. Sci. 2022, 23, 430. https://doi.org/ 10.3390/ijms23010430 |
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14220067 |
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https://hdl.handle.net/20.500.12442/9506 |
| dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.3390/ijms23010430 |
| identifier_str_mv |
Ortega, Á.; Vera, I.; Diaz, M.P.; Navarro, C.; Rojas, M.; Torres, W.; Parra, H.; Salazar, J.; Sanctis, J.B.D.; Bermúdez, V. The YAP/TAZ Signaling Pathway in the Tumor Microenvironment and Carcinogenesis: Current Knowledge and Therapeutic Promises. Int. J. Mol. Sci. 2022, 23, 430. https://doi.org/ 10.3390/ijms23010430 14220067 |
| url |
https://hdl.handle.net/20.500.12442/9506 https://doi.org/10.3390/ijms23010430 |
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eng |
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eng |
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Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
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http://purl.org/coar/access_right/c_abf2 |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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info:eu-repo/semantics/openAccess |
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Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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pdf |
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MDPI |
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International Journal of Molecular Sciences |
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Vol. 23, No. 1 (2022) |
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Universidad Simón Bolívar |
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Ortega, Ángelb6a809bb-4d26-4e53-9419-e4eb9fb40a9bVera, Ivana89ef899e-d9fb-4348-b1ff-f1b3543f4019Diaz, Maria P.14ead2c3-89e6-4410-ab5e-0b5697302235Navarro, Carla9892bf34-10a9-479a-8b3a-6769d4804207Rojas, Milagrosd07a9d4d-cce2-438c-b4a0-fc5ed4af1a67Torres, Wheelera82c8c05-2160-44dc-b397-ffc2ac51becaParra, Heliana13603b25-99ce-42ac-a469-5b65a89ce794Salazar, Juanfbd053e7-5aea-424c-812f-92153ecb9181De Sanctis, Juan B.ca98a00e-c126-4f97-bdb0-a08c25ad8c59Bermúdez, Valmore29f9aa18-16a4-4fd3-8ce5-ed94a0b8663a2022-04-01T18:28:42Z2022-04-01T18:28:42Z2022Ortega, Á.; Vera, I.; Diaz, M.P.; Navarro, C.; Rojas, M.; Torres, W.; Parra, H.; Salazar, J.; Sanctis, J.B.D.; Bermúdez, V. The YAP/TAZ Signaling Pathway in the Tumor Microenvironment and Carcinogenesis: Current Knowledge and Therapeutic Promises. Int. J. Mol. Sci. 2022, 23, 430. https://doi.org/ 10.3390/ijms2301043014220067https://hdl.handle.net/20.500.12442/9506https://doi.org/10.3390/ijms23010430The yes-associated protein (YAP) and the transcriptional coactivator with PDZ-binding motif (TAZ) are transcriptional coactivators, members of the Hippo signaling pathway, which play a critical role in cell growth regulation, embryonic development, regeneration, proliferation, and cancer origin and progression. The mechanism involves the nuclear binding of the un-phosphorylated YAP/TAZ complex to release the transcriptional enhanced associate domain (TEAD) from its repressors. The active ternary complex is responsible for the aforementioned biological effects. Overexpression of YAP/TAZ has been reported in cancer stem cells and tumor resistance. The resistance involves chemotherapy, targeted therapy, and immunotherapy. This review provides an overview of YAP/TAZ pathways’ role in carcinogenesis and tumor microenvironment. Potential therapeutic alternatives are also discussed.pdfengMDPIAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2International Journal of Molecular SciencesVol. 23, No. 1 (2022)YAP/TAZHippo signaling pathwaycarcinogenesisTumor microenvironmentneoplastic stem cellscell proliferationdrug resistancechemoresistanceimmunotherapyThe YAP/TAZ Signaling Pathway in the Tumor Microenvironment and Carcinogenesis: Current Knowledge and Therapeutic Promisesinfo:eu-repo/semantics/articleArtículo científicohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_2df8fbb1Ferlay, J.; Colombet, M.; Soerjomataram, I.; Parkin, D.M.; Piñeros, M.; Znaor, A.; Bray, F. Cancer Statistics for the Year 2020: An Overview. Int. J. Cancer 2021, 149, 778–789Bizzarri, M.; Cucina, A. 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