The YAP/TAZ Signaling Pathway in the Tumor Microenvironment and Carcinogenesis: Current Knowledge and Therapeutic Promises

The yes-associated protein (YAP) and the transcriptional coactivator with PDZ-binding motif (TAZ) are transcriptional coactivators, members of the Hippo signaling pathway, which play a critical role in cell growth regulation, embryonic development, regeneration, proliferation, and cancer origin and...

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Autores:
Ortega, Ángel
Vera, Ivana
Diaz, Maria P.
Navarro, Carla
Rojas, Milagros
Torres, Wheeler
Parra, Heliana
Salazar, Juan
De Sanctis, Juan B.
Bermúdez, Valmore
Tipo de recurso:
Fecha de publicación:
2022
Institución:
Universidad Simón Bolívar
Repositorio:
Repositorio Digital USB
Idioma:
eng
OAI Identifier:
oai:bonga.unisimon.edu.co:20.500.12442/9506
Acceso en línea:
https://hdl.handle.net/20.500.12442/9506
https://doi.org/10.3390/ijms23010430
Palabra clave:
YAP/TAZ
Hippo signaling pathway
carcinogenesis
Tumor microenvironment
neoplastic stem cells
cell proliferation
drug resistance
chemoresistance
immunotherapy
Rights
openAccess
License
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Description
Summary:The yes-associated protein (YAP) and the transcriptional coactivator with PDZ-binding motif (TAZ) are transcriptional coactivators, members of the Hippo signaling pathway, which play a critical role in cell growth regulation, embryonic development, regeneration, proliferation, and cancer origin and progression. The mechanism involves the nuclear binding of the un-phosphorylated YAP/TAZ complex to release the transcriptional enhanced associate domain (TEAD) from its repressors. The active ternary complex is responsible for the aforementioned biological effects. Overexpression of YAP/TAZ has been reported in cancer stem cells and tumor resistance. The resistance involves chemotherapy, targeted therapy, and immunotherapy. This review provides an overview of YAP/TAZ pathways’ role in carcinogenesis and tumor microenvironment. Potential therapeutic alternatives are also discussed.