Diclofenac Administration after Physical Training Blunts Adaptations of Peripheral Systems and Leads to Losses in Exercise Performance: In Vivo and In Silico Analyses

Recovery in athletes is hampered by soreness and fatigue. Consequently, nonsteroidal antiinflammatory drugs are used as an effective strategy to maintain high performance. However, impact of these drugs on adaptations induced by training remains unknown. This study assessed the effects of diclofenac...

Full description

Autores:
Pillon Barcelos, Rômulo
Diniz Lima, Frederico
Alves Courtes, Aline
Kich da Silva, Ingrid
Vargas, José Eduardo
Freire Royes, Luiz Fernando
Trindade, Cristiano
González-Gallego, Javier
Antunes Soares, Félix Alexandre
Tipo de recurso:
Fecha de publicación:
2021
Institución:
Universidad Simón Bolívar
Repositorio:
Repositorio Digital USB
Idioma:
eng
OAI Identifier:
oai:bonga.unisimon.edu.co:20.500.12442/8100
Acceso en línea:
https://hdl.handle.net/20.500.12442/8100
https://doi.org/10.3390/antiox10081246
https://www.mdpi.com/2076-3921/10/8/1246
Palabra clave:
NSAIDs
Physical training
Rat
Diclofenac
Inflammation
Oxidative stress
Systems biology
Systems pharmacology
Adaptation
Rights
openAccess
License
Attribution-NonCommercial-NoDerivatives 4.0 Internacional