Common interacting genetic variation shapes susceptibility to type 1 diabetes in a Colombian Caribbean community: In search of shared genetic markers

In summary, our study outlines oligogenic common variation underpinning the susceptibility to develop T1D. These genetic polymorphisms are also shared by patients suffering from other diseases such as LN and JIA, indicating that the shared genetic architecture defined by pleiotropy and epistasis shapes the genetic susceptibility of these disorders in this multiethnic population. Given the predicted functional nature of these genetic variants, it is very likely that in this understudied multiethnic population, genes harboring these mutations are major contributors to AID immunopathology and provide new insights into the autoimmune tautology in this group of diseases.

• Autores: Garavito-De Egea, Gloria; Domínguez-Vargas, Alex; Vélez, Jorge I.; Aroca, Gustavo; Fang, Luis; Navarro-Quiroz, Elkin; Espitaleta, Zilac; Del Toro-Camargo, Kenny; Martínez-Ariza, Leticia; González-Vargas, Tatiana; García, Susana; Arcos-Burgos, Mauricio
• Fecha de publicación: 2024
• Institución: Universidad Simón Bolívar
• Repositorio: Repositorio Digital USB
• Idioma: eng
• OAI Identifier: oai:bonga.unisimon.edu.co:20.500.12442/14702
• Acceso en línea: https://hdl.handle.net/20.500.12442/14702; https://doi.org/10.1016/j.gendis.2023.06.027; https://www.sciencedirect.com/science/article/pii/S2352304223003392?via%3Dihub
• Rights: openAccess
• License: Attribution-NonCommercial-NoDerivs 3.0 United States