The effect of nitric oxide supplementation therapies in the hemodynamic response and outcome during hemorrhagic shock in an animal model

Nitric oxide (NO) production is impaired after hemorrhagic shock (HS) due to reduced vascular endothelial shear stress (SS); uncoupling of endothelial NO synthase (eNOS) and hypoxia. We propose to supplement NO during resuscitation, using NO releasing nanoparticles (NO-np) and inhaled NO. Preliminar...