Systemic delivery of human GlyR IgG antibody induces GlyR internalization into motor neurons of brainstem and spinal cord with motor dysfunction in mice

Aims Progressive encephalomyelitis with rigidity and myoclonus (PERM) is a life‐threatening condition often associated with highly raised serum antibodies to glycine receptors (GlyRs); these bind to the surface of large neurons and interneurons in rodent brain and spinal cord sections and, in vitro,...

Full description

Autores:

Carvajal-González, Alexander
Jacobson, Leslie W.
Clover, Linda M.
Wickremaratchi, Mirdhu M.
Shields, S.
Lang, Bethan
Vincent, Angela V.

Tipo de recurso:

Article of journal

Fecha de publicación:

2020

Institución:

Universidad El Bosque

Repositorio:

Repositorio U. El Bosque

Idioma:

eng

OAI Identifier:

oai:repositorio.unbosque.edu.co:20.500.12495/4463

Acceso en línea:

http://hdl.handle.net/20.500.12495/4463
https://doi.org/10.1111/nan.12666

Palabra clave:

Animal model
Antibody-mediated autoimmune disease
Glycine receptor
PERM
Progressive encephalomyelitis with rigidity and myoclonus
Stiff person syndrome

Rights

openAccess

License

Attribution 4.0 International