A liaF codon deletion abolishes daptomycin bactericidal activity against vancomycin-resistant enterococcus faecalis
The genetic bases for antibiotic tolerance are obscure. Daptomycin (DAP) is a lipopeptide antibiotic with bactericidal activity against enterococci. Using time-kill assays, we provide evidence for the first time that a deletion of isoleucine in position 177 of LiaF, a member of the three-component r...
- Autores:
-
Munita, Jose M.
Tran, Truc T.
Diaz, Lorena
Panesso, Diana
Reyes, Jinnethe
Murray, Barbara E.
Arias, Cesar A.
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2013
- Institución:
- Universidad El Bosque
- Repositorio:
- Repositorio U. El Bosque
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.unbosque.edu.co:20.500.12495/3555
- Acceso en línea:
- http://hdl.handle.net/20.500.12495/3555
https://doi.org/10.1128/aac.00021-13
https://repositorio.unbosque.edu.co
- Palabra clave:
- Enterococcus faecalis
Vancomicina
Daptomicina
- Rights
- openAccess
- License
- Acceso abierto
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| dc.title.spa.fl_str_mv |
A liaF codon deletion abolishes daptomycin bactericidal activity against vancomycin-resistant enterococcus faecalis |
| dc.title.translated.spa.fl_str_mv |
A liaF codon deletion abolishes daptomycin bactericidal activity against vancomycin-resistant E}enterococcus faecalis |
| title |
A liaF codon deletion abolishes daptomycin bactericidal activity against vancomycin-resistant enterococcus faecalis |
| spellingShingle |
A liaF codon deletion abolishes daptomycin bactericidal activity against vancomycin-resistant enterococcus faecalis Enterococcus faecalis Vancomicina Daptomicina |
| title_short |
A liaF codon deletion abolishes daptomycin bactericidal activity against vancomycin-resistant enterococcus faecalis |
| title_full |
A liaF codon deletion abolishes daptomycin bactericidal activity against vancomycin-resistant enterococcus faecalis |
| title_fullStr |
A liaF codon deletion abolishes daptomycin bactericidal activity against vancomycin-resistant enterococcus faecalis |
| title_full_unstemmed |
A liaF codon deletion abolishes daptomycin bactericidal activity against vancomycin-resistant enterococcus faecalis |
| title_sort |
A liaF codon deletion abolishes daptomycin bactericidal activity against vancomycin-resistant enterococcus faecalis |
| dc.creator.fl_str_mv |
Munita, Jose M. Tran, Truc T. Diaz, Lorena Panesso, Diana Reyes, Jinnethe Murray, Barbara E. Arias, Cesar A. |
| dc.contributor.author.none.fl_str_mv |
Munita, Jose M. Tran, Truc T. Diaz, Lorena Panesso, Diana Reyes, Jinnethe Murray, Barbara E. Arias, Cesar A. |
| dc.contributor.orcid.none.fl_str_mv |
Panesso, Diana [0000-0002-4049-9702] |
| dc.subject.decs.spa.fl_str_mv |
Enterococcus faecalis Vancomicina Daptomicina |
| topic |
Enterococcus faecalis Vancomicina Daptomicina |
| description |
The genetic bases for antibiotic tolerance are obscure. Daptomycin (DAP) is a lipopeptide antibiotic with bactericidal activity against enterococci. Using time-kill assays, we provide evidence for the first time that a deletion of isoleucine in position 177 of LiaF, a member of the three-component regulatory system LiaFSR involved in the cell envelope response to antimicrobials, is directly responsible for a DAP-tolerant phenotype and is likely to negatively affect response to DAP therapy. |
| publishDate |
2013 |
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2013 |
| dc.date.accessioned.none.fl_str_mv |
2020-07-17T17:53:32Z |
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2020-07-17T17:53:32Z |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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Artículo de revista |
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http://purl.org/coar/resource_type/c_6501 |
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info:eu-repo/semantics/article |
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http://purl.org/coar/resource_type/c_6501 |
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1098-6596 |
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http://hdl.handle.net/20.500.12495/3555 |
| dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1128/aac.00021-13 |
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instname:Universidad El Bosque |
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reponame:Repositorio Institucional Universidad El Bosque |
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https://repositorio.unbosque.edu.co |
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1098-6596 instname:Universidad El Bosque reponame:Repositorio Institucional Universidad El Bosque |
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http://hdl.handle.net/20.500.12495/3555 https://doi.org/10.1128/aac.00021-13 https://repositorio.unbosque.edu.co |
| dc.language.iso.none.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartofseries.spa.fl_str_mv |
Antimicrobial Agents and Chemotherapy, 1098-6596, Vol. 57, No. 6, 2013 p. 2831-2833 |
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https://aac.asm.org/content/57/6/2831.long |
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Acceso abierto |
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http://purl.org/coar/access_right/c_abf2 info:eu-repo/semantics/openAccess Acceso abierto |
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2013-06 |
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Acceso abierto http://purl.org/coar/access_right/c_abf2 2013-06 |
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openAccess |
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application/pdf |
| dc.publisher.spa.fl_str_mv |
American Society for Microbiology |
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Antimicrobial Agents and Chemotherapy |
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Munita, Jose M.Tran, Truc T.Diaz, LorenaPanesso, DianaReyes, JinnetheMurray, Barbara E.Arias, Cesar A.Panesso, Diana [0000-0002-4049-9702]2020-07-17T17:53:32Z2020-07-17T17:53:32Z20131098-6596http://hdl.handle.net/20.500.12495/3555https://doi.org/10.1128/aac.00021-13instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquehttps://repositorio.unbosque.edu.coapplication/pdfengAmerican Society for MicrobiologyAntimicrobial Agents and ChemotherapyAntimicrobial Agents and Chemotherapy, 1098-6596, Vol. 57, No. 6, 2013 p. 2831-2833https://aac.asm.org/content/57/6/2831.longA liaF codon deletion abolishes daptomycin bactericidal activity against vancomycin-resistant enterococcus faecalisA liaF codon deletion abolishes daptomycin bactericidal activity against vancomycin-resistant E}enterococcus faecalisArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articlehttp://purl.org/coar/version/c_970fb48d4fbd8a85Enterococcus faecalisVancomicinaDaptomicinaThe genetic bases for antibiotic tolerance are obscure. Daptomycin (DAP) is a lipopeptide antibiotic with bactericidal activity against enterococci. Using time-kill assays, we provide evidence for the first time that a deletion of isoleucine in position 177 of LiaF, a member of the three-component regulatory system LiaFSR involved in the cell envelope response to antimicrobials, is directly responsible for a DAP-tolerant phenotype and is likely to negatively affect response to DAP therapy.Acceso abiertohttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessAcceso abierto2013-06ORIGINALMunita_Jose_M._2014.pdfMunita_Jose_M._2014.pdfapplication/pdf358369https://repositorio.unbosque.edu.co/bitstreams/f584ea1f-f84e-431d-ae1f-737d13ef09ee/downloade7869373ab09c46d1b8f5e5b30d12033MD51THUMBNAILMunita_Jose_M._2014.pdf.jpgMunita_Jose_M._2014.pdf.jpgIM Thumbnailimage/jpeg9768https://repositorio.unbosque.edu.co/bitstreams/a41f0b64-9bde-49ac-bad4-27fe04b9b7f7/download3a76e1c3b9ac34844c6455b78603dcadMD53LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.unbosque.edu.co/bitstreams/df169804-d8df-414a-918e-67f76d5201da/download8a4605be74aa9ea9d79846c1fba20a33MD52TEXTMunita_Jose_M._2014.pdf.txtMunita_Jose_M._2014.pdf.txtExtracted texttext/plain15038https://repositorio.unbosque.edu.co/bitstreams/05701a14-abe1-463a-8545-66a4d6865e9a/download08b9070a6c38ab8148f41e5cc276b5aaMD5420.500.12495/3555oai:repositorio.unbosque.edu.co:20.500.12495/35552024-02-07 01:30:21.797open.accesshttps://repositorio.unbosque.edu.coRepositorio Institucional Universidad El Bosquebibliotecas@biteca.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 |