Efficacy of telavancin alone and in Combination with ampicillin in a rat model of enterococcus faecalis endocarditis
We first assessed telavancin (TLV) pharmacokinetics in rats after a single subcutaneous dose of 35 mg/kg of body weight. The pharmacokinetic data were used to predict a TLV dose that simulates human exposure, and the efficacy of TLV was then evaluated using a TLV dose of 21 mg/kg every 12 h against...
- Autores:
-
Tran, Truc T.
Tam, Vincent H.
Murray, Barbara E.
Arias, Cesar A.
Singh, Kavindra V.
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2020
- Institución:
- Universidad El Bosque
- Repositorio:
- Repositorio U. El Bosque
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.unbosque.edu.co:20.500.12495/3717
- Acceso en línea:
- http://hdl.handle.net/20.500.12495/3717
https://doi.org/10.1128/AAC.02489-16
https://repositorio.unbosque.edu.co
- Palabra clave:
- Telavancin
Enterococcus faecalis
Therapy
Rat endocarditis
- Rights
- openAccess
- License
- Acceso abierto