Thymidylate synthase gene variants as predictors of clinical response and toxicity to fluoropyrimidine-based chemotherapy for colorectal cancer

luoropyrimidines form the chemotherapy backbone of advanced and metastatic colorectal cancer (CRC). These drugs are frequently associated with toxicity events that result in dose adjustments and even suspension of the treatment. The thymidylate synthase (TYMS) gene is a potential marker of response...

Full description

Autores:

Castro-Rojas, Carlos A.
Esparza-Mota, Antonio R.
Hernández-Cabrera, Francisco
Romero-Díaz, Víktor Javier
González-Guerrero, Juan Francisco
Maldonado-Garza, Héctor Jesús
González Sánchez, Irma
Buenaventura-Cisneros, Sergio
Sánchez, Josefina Yoaly
ORTIZ-LOPEZ, ROCIO
Camacho, Alberto
Barboza-Quintana, Oralia
ROJAS-MARTINEZ, AUGUSTO

Tipo de recurso:

Article of journal

Fecha de publicación:

2017

Institución:

Universidad El Bosque

Repositorio:

Repositorio U. El Bosque

Idioma:

eng

OAI Identifier:

oai:repositorio.unbosque.edu.co:20.500.12495/3507

Acceso en línea:

http://hdl.handle.net/20.500.12495/3507
https://doi.org/10.1515/dmpt-2017-0028
https://repositorio.unbosque.edu.co

Palabra clave:

Toxicidad
Quimioterapia
Neoplasias colorrectales
Colorectal cancer
Fluoropyrimidines
Objective response rate

Rights

openAccess

License

Acceso abierto