Perturbations of phosphatidate cytidylyltransferase (CdsA) mediate daptomycin resistance in Streptococcus mitis/oralis by a novel mechanism

Streptococcus mitis/oralis is an important pathogen, causing life-threatening infections such as endocarditis and severe sepsis in immunocompromised patients. The β-lactam antibiotics are the usual therapy of choice for this organism, but their effectiveness is threatened by the frequent emergence o...

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Autores:

Mishra, Nagendra Nath
Tran, Truc T.
Seepersaud, Ravin
García-De-La-Mària, Cristina
Faull, Kym F.
Yoon, Alexander J.
Proctor, Richard A.
Miró, José María
Rybak, Michael Joseph
Bayer, Arnold S.
Arias, César A.
Sullam, Paul M.

Tipo de recurso:

Article of journal

Fecha de publicación:

2017

Institución:

Universidad El Bosque

Repositorio:

Repositorio U. El Bosque

Idioma:

eng

OAI Identifier:

oai:repositorio.unbosque.edu.co:20.500.12495/3389

Acceso en línea:

http://hdl.handle.net/20.500.12495/3389
https://doi.org/10.1128/aac.02435-16
https://repositorio.unbosque.edu.co

Palabra clave:

Péptidos catiónicos antimicrobianos
Cardiolipinas
Cloranfenicol
Streptococcus mitis/orali
Phosphatidate cytidylyltransferase
Daptomycin resistance

Rights

openAccess

License

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