Two mutations commonly associated with daptomycin resistance in enterococcus faecium liaST120A and liaRW73C appear to function epistatically in liaFSR signaling

The cyclic antimicrobial lipopeptide daptomycin is now frequently used as a first-line therapy in serious infections caused by multidrug-resistant Enterococcus faecium. Resistance to daptomycin in E. faecium is mediated by activation of the LiaFSR membrane stress response pathway. Deletion of liaR,...

Full description

Autores:

Davlieva, Milya
Wu, Chelsea
Zhou, Yue
Arias, Cesar A.
Shamoo, Yousif

Tipo de recurso:

Article of journal

Fecha de publicación:

2018

Institución:

Universidad El Bosque

Repositorio:

Repositorio U. El Bosque

Idioma:

eng

OAI Identifier:

oai:repositorio.unbosque.edu.co:20.500.12495/2950

Acceso en línea:

http://hdl.handle.net/20.500.12495/2950
https://doi.org/10.1021/acs.biochem.8b01072
https://repositorio.unbosque.edu.co

Palabra clave:

Péptidos cíclicos
Proteínas asociadas a resistencia a múltiples medicamentos
Infecciones bacterianas

Rights

openAccess

License

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