An adaptive mutation in enterococcus faecium LiaR associated with antimicrobial peptide resistance mimics phosphorylation and stabilizes LiaR in an activated state

The cyclic antimicrobial lipopeptide daptomycin (DAP) triggers the LiaFSR membrane stress response pathway in enterococci and many other Gram-positive organisms. LiaR is the response regulator that, upon phosphorylation, binds in a sequence-specific manner to DNA to regulate transcription in respons...

Full description

Autores:

Davlieva, Milya G.
Tovar-Yanez, Angel
DeBruler, Kimberly
Leonard, Paul G.
Zianni, Michael R.
Arias, César A.
Shamoo, Yousif

Tipo de recurso:

Article of journal

Fecha de publicación:

2020

Institución:

Universidad El Bosque

Repositorio:

Repositorio U. El Bosque

Idioma:

eng

OAI Identifier:

oai:repositorio.unbosque.edu.co:20.500.12495/3526

Acceso en línea:

http://hdl.handle.net/20.500.12495/3526
https://doi.org/10.1016/j.jmb.2016.09.016
https://repositorio.unbosque.edu.co

Palabra clave:

Daptomicina
Diagnóstico por imagen
Enterococos resistentes a la vancomicina
LiaR
E. faecium
Response regulator

Rights

openAccess

License

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