Candesartan exhibits low intrinsic permeation capacity and affects buccal tissue viability and integrity: An ex vivo study in porcine buccal mucosa

Candesartan is a nonpeptide angiotensin II receptor blocker that selectively binds to angiotensin II receptor subtype 1. It is administered orally in its ester form (candesartan cilexetil). However, its poor aqueous solubility results in its low bioavailability; therefore, other routes of administra...

Full description

Autores:

Garcia-Tarazona, Yenny M.
Morantes, Sandra Johanna
Gordillo, José Francisco Ibla
Sepúlveda, Paula
Ramos, Freddy A.
Lafaurie, Gloria Inés

Tipo de recurso:

Article of journal

Fecha de publicación:

2023

Institución:

Universidad El Bosque

Repositorio:

Repositorio U. El Bosque

Idioma:

eng

OAI Identifier:

oai:repositorio.unbosque.edu.co:20.500.12495/11246

Acceso en línea:

http://hdl.handle.net/20.500.12495/11246
https://doi.org/10.1016/j.ejps.2023.106495

Palabra clave:

Permeabilidad bucal
Candesartán
Histología Índice TR
Ensayo MTT
Buccal permeability
Candesartan
Histology TR index
MTT assay

Rights

openAccess

License

Atribución 4.0 Internacional