2-Mercaptomethyl thiazolidines (MMTZs) inhibit all metallo-β-lactamase classes by maintaining a conserved binding mode

Metallo-β-lactamase (MBL) production in Gram-negative bacteria is an important contributor to β-lactam antibiotic resistance. Combining β-lactams with β-lactamase inhibitors (BLIs) is a validated route to overcoming resistance, but MBL inhibitors are not available in the clinic. On the basis of zinc...

Full description

Autores:

Rossi, María Agustina
Martínez, Verónica
Villamil, Valentina
Spellberg, Brad J.
Drusano, George Louis
Banchio, Claudia
Bonomo, Robert A.
Hinchliffe, Philip

Tipo de recurso:

Article of journal

Fecha de publicación:

2021

Institución:

Universidad El Bosque

Repositorio:

Repositorio U. El Bosque

Idioma:

eng

OAI Identifier:

oai:repositorio.unbosque.edu.co:20.500.12495/7320

Acceso en línea:

http://hdl.handle.net/20.500.12495/7320
https://doi.org/10.1021/acsinfecdis.1c00194

Palabra clave:

Antibiotic resistance
β-lactamases
Inhibitors
Carbapenemase

Rights

openAccess

License

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