Evaluación del comportamiento fisicoquímico y antimicrobiano de complejos con polielectrolitos

ilustraciones, gráficas, tablas

Autores:: Carrascal Sánchez, Juan José

Tipo de recurso:: Doctoral thesis

Fecha de publicación:: 2021

Institución:: Universidad Nacional de Colombia

Repositorio:: Universidad Nacional de Colombia

Idioma:: spa

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network_acronym_str	UNACIONAL2
network_name_str	Universidad Nacional de Colombia
repository_id_str
dc.title.spa.fl_str_mv	Evaluación del comportamiento fisicoquímico y antimicrobiano de complejos con polielectrolitos
dc.title.translated.eng.fl_str_mv	Evaluation of the physicochemical and antimicrobial behavior of complexes with polyelectrolytes
title	Evaluación del comportamiento fisicoquímico y antimicrobiano de complejos con polielectrolitos
spellingShingle	Evaluación del comportamiento fisicoquímico y antimicrobiano de complejos con polielectrolitos 610 - Medicina y salud::615 - Farmacología y terapéutica Polielectrolitos Antiinfecciosos Productos con Acción Antimicrobiana Polyelectrolytes Anti-Infective Agents Products with Antimicrobial Action Polyelectrolyte complexes antimicrobial activity preservatives Extrusion Antimicrobial activity Complejos polielectrolíticos Secado Extrusión Actividad antimicrobiana Preservantes Drying
title_short	Evaluación del comportamiento fisicoquímico y antimicrobiano de complejos con polielectrolitos
title_full	Evaluación del comportamiento fisicoquímico y antimicrobiano de complejos con polielectrolitos
title_fullStr	Evaluación del comportamiento fisicoquímico y antimicrobiano de complejos con polielectrolitos
title_full_unstemmed	Evaluación del comportamiento fisicoquímico y antimicrobiano de complejos con polielectrolitos
title_sort	Evaluación del comportamiento fisicoquímico y antimicrobiano de complejos con polielectrolitos
dc.creator.fl_str_mv	Carrascal Sánchez, Juan José
dc.contributor.advisor.spa.fl_str_mv	Baena Aristizábal, Yolima Pérez, León Darío
dc.contributor.author.spa.fl_str_mv	Carrascal Sánchez, Juan José
dc.contributor.researchgroup.spa.fl_str_mv	Sistemas Para Liberación Controlada de Moléculas Biológicamente Activas
dc.subject.ddc.spa.fl_str_mv	610 - Medicina y salud::615 - Farmacología y terapéutica
topic	610 - Medicina y salud::615 - Farmacología y terapéutica Polielectrolitos Antiinfecciosos Productos con Acción Antimicrobiana Polyelectrolytes Anti-Infective Agents Products with Antimicrobial Action Polyelectrolyte complexes antimicrobial activity preservatives Extrusion Antimicrobial activity Complejos polielectrolíticos Secado Extrusión Actividad antimicrobiana Preservantes Drying
dc.subject.decs.spa.fl_str_mv	Polielectrolitos Antiinfecciosos Productos con Acción Antimicrobiana
dc.subject.decs.eng.fl_str_mv	Polyelectrolytes Anti-Infective Agents Products with Antimicrobial Action
dc.subject.proposal.eng.fl_str_mv	Polyelectrolyte complexes antimicrobial activity preservatives Extrusion Antimicrobial activity
dc.subject.proposal.spa.fl_str_mv	Complejos polielectrolíticos Secado Extrusión Actividad antimicrobiana Preservantes Drying
description	ilustraciones, gráficas, tablas
publishDate	2021
dc.date.issued.none.fl_str_mv	2021
dc.date.accessioned.none.fl_str_mv	2022-07-18T23:59:14Z
dc.date.available.none.fl_str_mv	2022-07-18T23:59:14Z
dc.type.spa.fl_str_mv	Trabajo de grado - Doctorado
dc.type.driver.spa.fl_str_mv	info:eu-repo/semantics/doctoralThesis
dc.type.version.spa.fl_str_mv	info:eu-repo/semantics/acceptedVersion
dc.type.coar.spa.fl_str_mv	http://purl.org/coar/resource_type/c_db06
dc.type.content.spa.fl_str_mv	Text
dc.type.redcol.spa.fl_str_mv	http://purl.org/redcol/resource_type/TD
format	http://purl.org/coar/resource_type/c_db06
status_str	acceptedVersion
dc.identifier.uri.none.fl_str_mv	https://repositorio.unal.edu.co/handle/unal/81703
dc.identifier.instname.spa.fl_str_mv	Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv	Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv	https://repositorio.unal.edu.co/
url	https://repositorio.unal.edu.co/handle/unal/81703 https://repositorio.unal.edu.co/
identifier_str_mv	Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv	spa
language	spa
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dc.format.extent.spa.fl_str_mv	xix, 249 páginas
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dc.publisher.spa.fl_str_mv	Universidad Nacional de Colombia
dc.publisher.program.spa.fl_str_mv	Bogotá - Ciencias - Doctorado en Ciencias Farmacéuticas
dc.publisher.department.spa.fl_str_mv	Departamento de Farmacia
dc.publisher.faculty.spa.fl_str_mv	Facultad de Ciencias
dc.publisher.place.spa.fl_str_mv	Bogotá, Colombia
dc.publisher.branch.spa.fl_str_mv	Universidad Nacional de Colombia - Sede Bogotá
institution	Universidad Nacional de Colombia
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spelling	Reconocimiento 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Baena Aristizábal, Yolimaf595d9eaf58da3826f80cd738dae8d45600Pérez, León Darío6d9d27b5535bcad523977ed43e079cabCarrascal Sánchez, Juan José4471cc3cfad682591305c9c33940b3c8600Sistemas Para Liberación Controlada de Moléculas Biológicamente Activas2022-07-18T23:59:14Z2022-07-18T23:59:14Z2021https://repositorio.unal.edu.co/handle/unal/81703Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, gráficas, tablasLas interacciones electrostáticas entre un polielectrolito y una molécula ionizable conducen a la formación de un complejo polielectrolítico (CPE), cuyas propiedades fisicoquímicas se diferencian de los materiales de partida. Estas propiedades han sido aprovechadas en el campo farmacéutico y cosmético, con propósitos como la estabilización de moléculas y la mejora de la actividad. El objetivo de este estudio fue caracterizar las propiedades fisicoquímicas y antimicrobianas de CPEs obtenidos entre el Eudragit E100 (Eu) y los ácidos benzoico, salicílico y 4-hidroxibenzoico, con diferentes proporciones estequiométricas de neutralización y producidos mediante extrusión por fusión (HME) y secado por aspersión (SD). Con base en diagramas de fases y un diseño estadístico experimental, se establecieron las condiciones operacionales de las dos metodologías. Las interacciones intermoleculares fueron evidenciadas mediante espectroscopía infrarroja por transformada de Fourier (FTIR), espectroscopía de fotoelectrones de rayos X (XPS) y difracción de rayos X en polvo (XRPD). Las propiedades fisicoquímicas temperatura de transición vítrea, desplazamiento químico del N1s, solubilidad cualitativa, pseudo potencial zeta (F-ζ) y el comportamiento de liberación, fueron dependientes de la constitución del CPE y de la metodología de obtención. La actividad antimicrobiana de los CPEs sobre E.coli, S.aureus y C.albicans fue superior en comparación con los materiales de partida, a pH 6.0 y 6.9. La correlación entre el F-ζ y la actividad antimicrobiana demostró relación directa, independiente del pH y la metodología de obtención. Dicha relación es atribuida a la interacción entre la carga de los CPEs y los componentes de la superficie de la membrana celular, que corresponde al principal mecanismo de acción que fue determinado para estos sistemas. El mayor espectro de acción y su mayor actividad en un rango más amplio de pH, hace que estos complejos puedan ser considerados como una nueva alternativa frente a los preservantes existentes, con aplicación en el campo farmacéutico y cosmético. (Texto tomado de la fuente).Electrostatic interactions between a polyelectrolyte and an ionizable molecule led to the formation of a polyelectrolyte complex (PEC), whose physicochemical properties differ from the starting materials. These properties have been applied in the pharmaceutical and cosmetic fields, for purposes such as stabilizing molecules and improving activity. The objective of this study was to characterize the physicochemical and antimicrobial properties of PECs obtained between Eudragit E100 and benzoic, salicylic, and 4-hydroxybenzoic acids, with different stoichiometric proportions of neutralization and produced by hot-melt extrusion (HME) and spray drying (SD). Based on phase diagrams and an experimental statistical design, the operational conditions of the two methodologies were established. Intermolecular interactions were evidenced by Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), and X-ray powder diffraction (XRPD). The physicochemical properties, glass transition temperature, N1s chemical shift, qualitative solubility, pseudo zeta potential (F-ζ), and release behavior were dependent on the constitution of the PEC and the production methodology. The antimicrobial activity of the PECs on E.coli, S.aureus, and C.albicans was superior compared to the starting materials, at pH 6.0 and 6.9. The correlation between F-ζ and antimicrobial activity showed a direct relationship, independent of pH and the methodology of obtaining. This relationship is attributed to the interaction between the charge of the PECs and the components of the cell membrane surface, which corresponds to the main mechanism of action that was determined for these systems. The greater spectrum of action and their greater activity in a wider range of pH make that these complexes could be considered as a new alternative to existing preservatives, with application in the pharmaceutical and cosmetic fields.Incluye anexosDoctoradoDoctor en Ciencias FarmacéuticasSistemas conformados por complejos con polielectrolitosxix, 249 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Ciencias - Doctorado en Ciencias FarmacéuticasDepartamento de FarmaciaFacultad de CienciasBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá610 - Medicina y salud::615 - Farmacología y terapéuticaPolielectrolitosAntiinfecciososProductos con Acción AntimicrobianaPolyelectrolytesAnti-Infective AgentsProducts with Antimicrobial ActionPolyelectrolyte complexesantimicrobial activitypreservativesExtrusionAntimicrobial activityComplejos polielectrolíticosSecadoExtrusiónActividad antimicrobianaPreservantesDryingEvaluación del comportamiento fisicoquímico y antimicrobiano de complejos con polielectrolitosEvaluation of the physicochemical and antimicrobial behavior of complexes with polyelectrolytesTrabajo de grado - Doctoradoinfo:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_db06Texthttp://purl.org/redcol/resource_type/TDManiruzzaman M, Morgan DJ, Mendham AP, Pang J, Snowden MJ, Douroumis D. 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Academic Press; 2013. 392 p.Ministerio de Ciencia Tecnología e InnovaciónEstudiantesInvestigadoresPúblico generalORIGINAL8101727.2022.pdf8101727.2022.pdfTesis de Doctorado en Ciencias Farmacéuticasapplication/pdf14840848https://repositorio.unal.edu.co/bitstream/unal/81703/3/8101727.2022.pdf31ecd5672f7ab8388c401799075f3489MD53LICENSElicense.txtlicense.txttext/plain; charset=utf-84074https://repositorio.unal.edu.co/bitstream/unal/81703/4/license.txt8153f7789df02f0a4c9e079953658ab2MD54THUMBNAIL8101727.2022.pdf.jpg8101727.2022.pdf.jpgGenerated Thumbnailimage/jpeg4575https://repositorio.unal.edu.co/bitstream/unal/81703/5/8101727.2022.pdf.jpg5ba297b46ada3425f8196ff5e18b7408MD55unal/81703oai:repositorio.unal.edu.co:unal/817032024-08-06 23:09:59.847Repositorio Institucional Universidad Nacional de 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