Estudio de la composición del hongo Lentinula edodes usando herramientas ómicas y su potencial en la producción de un alimento funcional

Lentinula edodes es una especie fúngica perteneciente a los macromicetos para la cual se han reportado metabolitos y proteínas que presentan diversas actividades biológicas con potencial en la industria de alimentos. En la presente tesis doctoral se aporta al conocimiento bioquímico de este potencia...

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Autores:
Vega Oliveros, Carolina
Tipo de recurso:
Doctoral thesis
Fecha de publicación:
2021
Institución:
Universidad Nacional de Colombia
Repositorio:
Universidad Nacional de Colombia
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spa
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oai:repositorio.unal.edu.co:unal/81964
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https://repositorio.unal.edu.co/handle/unal/81964
https://repositorio.unal.edu.co/
Palabra clave:
570 - Biología::579 - Historia natural microorganismos, hongos, algas
Lentinula edodes
Fermentación sumergida
Bioactivo
Metabolitos
Macromiceto
Funcional
Nutracéutico
Submerged fermentation
Bioactive
Metabolites
Macromycete
Functional
Nutraceutical
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openAccess
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Atribución-NoComercial-SinDerivadas 4.0 Internacional
id UNACIONAL2_b77e706afb84439339fc79256e58e620
oai_identifier_str oai:repositorio.unal.edu.co:unal/81964
network_acronym_str UNACIONAL2
network_name_str Universidad Nacional de Colombia
repository_id_str
dc.title.spa.fl_str_mv Estudio de la composición del hongo Lentinula edodes usando herramientas ómicas y su potencial en la producción de un alimento funcional
dc.title.translated.eng.fl_str_mv Study of the composition of the mushroom Lentinula edodes using omics tools and its potential in the production of a functional food
title Estudio de la composición del hongo Lentinula edodes usando herramientas ómicas y su potencial en la producción de un alimento funcional
spellingShingle Estudio de la composición del hongo Lentinula edodes usando herramientas ómicas y su potencial en la producción de un alimento funcional
570 - Biología::579 - Historia natural microorganismos, hongos, algas
Lentinula edodes
Fermentación sumergida
Bioactivo
Metabolitos
Macromiceto
Funcional
Nutracéutico
Submerged fermentation
Bioactive
Metabolites
Macromycete
Functional
Nutraceutical
title_short Estudio de la composición del hongo Lentinula edodes usando herramientas ómicas y su potencial en la producción de un alimento funcional
title_full Estudio de la composición del hongo Lentinula edodes usando herramientas ómicas y su potencial en la producción de un alimento funcional
title_fullStr Estudio de la composición del hongo Lentinula edodes usando herramientas ómicas y su potencial en la producción de un alimento funcional
title_full_unstemmed Estudio de la composición del hongo Lentinula edodes usando herramientas ómicas y su potencial en la producción de un alimento funcional
title_sort Estudio de la composición del hongo Lentinula edodes usando herramientas ómicas y su potencial en la producción de un alimento funcional
dc.creator.fl_str_mv Vega Oliveros, Carolina
dc.contributor.advisor.none.fl_str_mv Ardila Barrantes, Harold Duban
Chegwin Angarita, Carolina
dc.contributor.author.none.fl_str_mv Vega Oliveros, Carolina
dc.contributor.researchgroup.spa.fl_str_mv Estudio de Actividades Metabolicas Vegetales
Química de Hongos Macromicetos Colombianos
dc.subject.ddc.spa.fl_str_mv 570 - Biología::579 - Historia natural microorganismos, hongos, algas
topic 570 - Biología::579 - Historia natural microorganismos, hongos, algas
Lentinula edodes
Fermentación sumergida
Bioactivo
Metabolitos
Macromiceto
Funcional
Nutracéutico
Submerged fermentation
Bioactive
Metabolites
Macromycete
Functional
Nutraceutical
dc.subject.agrovoc.none.fl_str_mv Lentinula edodes
dc.subject.proposal.spa.fl_str_mv Fermentación sumergida
Bioactivo
Metabolitos
Macromiceto
Funcional
Nutracéutico
dc.subject.proposal.eng.fl_str_mv Submerged fermentation
Bioactive
Metabolites
Macromycete
Functional
Nutraceutical
description Lentinula edodes es una especie fúngica perteneciente a los macromicetos para la cual se han reportado metabolitos y proteínas que presentan diversas actividades biológicas con potencial en la industria de alimentos. En la presente tesis doctoral se aporta al conocimiento bioquímico de este potencial, mediante la exploración química y el estudio de bioactividad presente en el micelio de esta especie obtenido mediante fermentación en estado líquido (FEL); estrategia de cultivo biotecnológico que permite la obtención eficiente de material biológico con fines industriales. Para ello inicialmente se determinaron algunos parámetros experimentales para su cultivo en condiciones de laboratorio y se seleccionaron dos medios que presentaron los mejores resultados en la producción de metabolitos y proteínas totales. Posteriormente usando ensayos de actividad biológica in vitro y estrategias propias de la proteómica y la metabolómica, se estudió la composición del micelio producido en dichos medios y se profundizó sobre sus potenciales características nutracéuticas. De acuerdo con los resultados encontrados en la presente investigación, el micelio producido mediante FEL en medios como GPY (Glucosa, Peptona y Levadura) y Bienestarina, presenta metabolitos y proteínas con potenciales usos en la industria de alimentos. Específicamente, el micelio obtenido en medio GPY mostró importante actividad antioxidante evaluada sobre EROs (especies reactivas de oxígeno) y ERN (especies reactivas de nitrógeno); muy posiblemente asociada a la presencia de diferentes compuestos hidroxilados, incluyendo un derivado de tipo flavanona. Así mismo, el micelio generado a partir del medio bienestarina contiene diversas proteínas con usos potenciales en la industria de alimentos, incluyendo algunas lectinas con reportada acción inmunomoduladora. El estudio preliminar de la incorporación del micelio obtenido en un alimento de tipo postre, permitió profundizar sobre el potencial del hongo propagado en GPY para ser usado en la generación de alimentos con potencial nutraceutico. La presente investigación profundiza sobre la bioquímica de la producción de metabolitos y proteínas en esta especie y se constituye como el primer estudio conjunto a nivel proteómico y metabolómico del potencial nutracéutico en macromicetos. (Texto tomado de la fuente)
publishDate 2021
dc.date.issued.none.fl_str_mv 2021
dc.date.accessioned.none.fl_str_mv 2022-08-18T20:07:45Z
dc.date.available.none.fl_str_mv 2022-08-18T20:07:45Z
dc.type.spa.fl_str_mv Trabajo de grado - Doctorado
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/doctoralThesis
dc.type.version.spa.fl_str_mv info:eu-repo/semantics/acceptedVersion
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_db06
dc.type.content.spa.fl_str_mv Text
dc.type.redcol.spa.fl_str_mv http://purl.org/redcol/resource_type/TD
format http://purl.org/coar/resource_type/c_db06
status_str acceptedVersion
dc.identifier.uri.none.fl_str_mv https://repositorio.unal.edu.co/handle/unal/81964
dc.identifier.instname.spa.fl_str_mv Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv https://repositorio.unal.edu.co/
url https://repositorio.unal.edu.co/handle/unal/81964
https://repositorio.unal.edu.co/
identifier_str_mv Universidad Nacional de Colombia
Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv spa
language spa
dc.relation.indexed.spa.fl_str_mv RedCol
LaReferencia
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dc.publisher.spa.fl_str_mv Universidad Nacional de Colombia
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dc.publisher.department.spa.fl_str_mv Departamento de Química
dc.publisher.faculty.spa.fl_str_mv Facultad de Ciencias
dc.publisher.place.spa.fl_str_mv Bogotá, Colombia
dc.publisher.branch.spa.fl_str_mv Universidad Nacional de Colombia - Sede Bogotá
institution Universidad Nacional de Colombia
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spelling Atribución-NoComercial-SinDerivadas 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Ardila Barrantes, Harold Duban3c0b4dc91cdf02792559faddcd37e2b3Chegwin Angarita, Carolina04e1dc7774dc51a9525d964cb6addc0aVega Oliveros, Carolinaccd108702baec235e711c66a359d8523Estudio de Actividades Metabolicas VegetalesQuímica de Hongos Macromicetos Colombianos2022-08-18T20:07:45Z2022-08-18T20:07:45Z2021https://repositorio.unal.edu.co/handle/unal/81964Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/Lentinula edodes es una especie fúngica perteneciente a los macromicetos para la cual se han reportado metabolitos y proteínas que presentan diversas actividades biológicas con potencial en la industria de alimentos. En la presente tesis doctoral se aporta al conocimiento bioquímico de este potencial, mediante la exploración química y el estudio de bioactividad presente en el micelio de esta especie obtenido mediante fermentación en estado líquido (FEL); estrategia de cultivo biotecnológico que permite la obtención eficiente de material biológico con fines industriales. Para ello inicialmente se determinaron algunos parámetros experimentales para su cultivo en condiciones de laboratorio y se seleccionaron dos medios que presentaron los mejores resultados en la producción de metabolitos y proteínas totales. Posteriormente usando ensayos de actividad biológica in vitro y estrategias propias de la proteómica y la metabolómica, se estudió la composición del micelio producido en dichos medios y se profundizó sobre sus potenciales características nutracéuticas. De acuerdo con los resultados encontrados en la presente investigación, el micelio producido mediante FEL en medios como GPY (Glucosa, Peptona y Levadura) y Bienestarina, presenta metabolitos y proteínas con potenciales usos en la industria de alimentos. Específicamente, el micelio obtenido en medio GPY mostró importante actividad antioxidante evaluada sobre EROs (especies reactivas de oxígeno) y ERN (especies reactivas de nitrógeno); muy posiblemente asociada a la presencia de diferentes compuestos hidroxilados, incluyendo un derivado de tipo flavanona. Así mismo, el micelio generado a partir del medio bienestarina contiene diversas proteínas con usos potenciales en la industria de alimentos, incluyendo algunas lectinas con reportada acción inmunomoduladora. El estudio preliminar de la incorporación del micelio obtenido en un alimento de tipo postre, permitió profundizar sobre el potencial del hongo propagado en GPY para ser usado en la generación de alimentos con potencial nutraceutico. La presente investigación profundiza sobre la bioquímica de la producción de metabolitos y proteínas en esta especie y se constituye como el primer estudio conjunto a nivel proteómico y metabolómico del potencial nutracéutico en macromicetos. (Texto tomado de la fuente)Lentinula edodes is a fungal species belonging to the macromycetes for which various biological activities with potential in the food industry have been reported due to its proteins and metabolites. This doctoral thesis contributes to the biochemical knowledge of this potential through chemical exploration and the study of bioactivity present in the mycelium of this species obtained by liquid-state fermentation (FEL); biotechnological cultivation strategy that allows the efficient obtaining of biological material for industrial purposes. For this, some experimental parameters were initially determined for their culture in laboratory conditions, and two liquid media were selected because they induced the mushroom to the best results in the production of metabolites and total proteins. Subsequently, the composition of the mycelium produced was studied using in vitro biological activity tests and strategies of proteomics and metabolomics, and the nutraceutical characteristics potential of their mycelia were studied. According to the results found in the present investigation, the mycelium produced by FEL in GPY media (Glucose, Peptone, and Yeast) and BIE (Bienestarina) presented metabolites and proteins with potential uses in the food industry. Specifically, the mycelium obtained in GPY medium presented important antioxidant activity evaluated on ROS (reactive oxygen species) and RNS (reactive nitrogen species); this antioxidant activity could be associated with the presence of different hydroxylated compounds, including a derivative of the flavanone type. Likewise, the mycelium generated from the BIE medium presented a wide variety of proteins with potential uses in the food industry, including some lectins with reported immunomodulatory action. The preliminary study of incorporating the mycelium obtained in a dessert-type food allowed to deepen the potential of the fungus propagated in GPY to be used in the generation of food formulations with nutraceutical potential. This research delves into the biochemistry of the production of metabolites and proteins in this species and constitutes the first joint study at the proteomic and metabolomic level of the nutraceutical potential in macromycetes.DoctoradoDoctorado en Ciencias - Bioquímicaxxv, 325 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Ciencias - Doctorado en Ciencias - BioquímicaDepartamento de QuímicaFacultad de CienciasBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá570 - Biología::579 - Historia natural microorganismos, hongos, algasLentinula edodesFermentación sumergidaBioactivoMetabolitosMacromicetoFuncionalNutracéuticoSubmerged fermentationBioactiveMetabolitesMacromyceteFunctionalNutraceuticalEstudio de la composición del hongo Lentinula edodes usando herramientas ómicas y su potencial en la producción de un alimento funcionalStudy of the composition of the mushroom Lentinula edodes using omics tools and its potential in the production of a functional foodTrabajo de grado - Doctoradoinfo:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_db06Texthttp://purl.org/redcol/resource_type/TDRedColLaReferenciaRathore H, Prasad S, Sharma S. 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Available from: http://dx.doi.org/10.1016/j.biortech.2017.01.064Crédito condonable Convocatoria 785 de colciencias para doctorados nacionales 2017Diseño bioguiado apoyado con herramientas ómicas de un alimento funcional obtenido mediante la adición del hongo Lentinula edodes (Código 47146)Potencial del hongo Lentinula edodes como productor de nutraceúticos en biorreactores (código 41634)Bioprospección de hongos macromicetos en busca de fuentes de materias primas para la industria alimenticia y agrícola (código 41455)MinCienciasUniversidad Nacional de Colombia sede BogotáEstudiantesInvestigadoresMaestrosPúblico generalReceptores de fondos federales y solicitantesORIGINAL52888760.2022.pdf52888760.2022.pdfTesis de Doctorado en Ciencias - Bioquímicaapplication/pdf7881080https://repositorio.unal.edu.co/bitstream/unal/81964/3/52888760.2022.pdfd7eb0d369cf85163f65037a62e7586bbMD53LICENSElicense.txtlicense.txttext/plain; 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EVESURBIFBPUiBMQSBTRUNSRVRBUsONQSBHRU5FUkFMLiAqTEEgVEVTSVMgQSBQVUJMSUNBUiBERUJFIFNFUiBMQSBWRVJTScOTTiBGSU5BTCBBUFJPQkFEQS4gCgpBbCBoYWNlciBjbGljIGVuIGVsIHNpZ3VpZW50ZSBib3TDs24sIHVzdGVkIGluZGljYSBxdWUgZXN0w6EgZGUgYWN1ZXJkbyBjb24gZXN0b3MgdMOpcm1pbm9zLiBTaSB0aWVuZSBhbGd1bmEgZHVkYSBzb2JyZSBsYSBsaWNlbmNpYSwgcG9yIGZhdm9yLCBjb250YWN0ZSBjb24gZWwgYWRtaW5pc3RyYWRvciBkZWwgc2lzdGVtYS4KClVOSVZFUlNJREFEIE5BQ0lPTkFMIERFIENPTE9NQklBIC0gw5psdGltYSBtb2RpZmljYWNpw7NuIDE5LzEwLzIwMjEK

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