Desarrollo de aditivos alimenticios con base en las propiedades biofuncionales del Agraz (Vaccinium meridionale Swartz)

ilustraciones, diagramas, fotografías a color

Autores:: Amaya Gómez, Andrés Mauricio

Tipo de recurso:

Fecha de publicación:: 2023

Institución:: Universidad Nacional de Colombia

Repositorio:: Universidad Nacional de Colombia

Idioma:: spa

id	UNACIONAL2_802685ffd197761b21df08145dc0cd46
oai_identifier_str	oai:repositorio.unal.edu.co:unal/84585
network_acronym_str	UNACIONAL2
network_name_str	Universidad Nacional de Colombia
repository_id_str
dc.title.spa.fl_str_mv	Desarrollo de aditivos alimenticios con base en las propiedades biofuncionales del Agraz (Vaccinium meridionale Swartz)
dc.title.translated.none.fl_str_mv	Food additives development based on biofunctional properties of agraz (Vaccinium meridionale Swartz)
title	Desarrollo de aditivos alimenticios con base en las propiedades biofuncionales del Agraz (Vaccinium meridionale Swartz)
spellingShingle	Desarrollo de aditivos alimenticios con base en las propiedades biofuncionales del Agraz (Vaccinium meridionale Swartz) 600 - Tecnología (Ciencias aplicadas) Industrias alimenticias Procesos agrícolas Food industry and trade Agricultural processing Microencapsulación Antocianinas Ericaceae Actividad antihipertensiva Panes fortificados Microencapsulation Anthocyanins Ericaceae Antihypertensive activity Fortified breads
title_short	Desarrollo de aditivos alimenticios con base en las propiedades biofuncionales del Agraz (Vaccinium meridionale Swartz)
title_full	Desarrollo de aditivos alimenticios con base en las propiedades biofuncionales del Agraz (Vaccinium meridionale Swartz)
title_fullStr	Desarrollo de aditivos alimenticios con base en las propiedades biofuncionales del Agraz (Vaccinium meridionale Swartz)
title_full_unstemmed	Desarrollo de aditivos alimenticios con base en las propiedades biofuncionales del Agraz (Vaccinium meridionale Swartz)
title_sort	Desarrollo de aditivos alimenticios con base en las propiedades biofuncionales del Agraz (Vaccinium meridionale Swartz)
dc.creator.fl_str_mv	Amaya Gómez, Andrés Mauricio
dc.contributor.advisor.none.fl_str_mv	Osorio Roa, Coralia Otalora, María Carolina
dc.contributor.author.none.fl_str_mv	Amaya Gómez, Andrés Mauricio
dc.contributor.researchgroup.spa.fl_str_mv	Grupo Aditivos Naturales de Aroma y Colorganac
dc.contributor.orcid.spa.fl_str_mv	Amaya, Andres Mauricio [0009-0009-4689-4859]
dc.subject.ddc.spa.fl_str_mv	600 - Tecnología (Ciencias aplicadas)
topic	600 - Tecnología (Ciencias aplicadas) Industrias alimenticias Procesos agrícolas Food industry and trade Agricultural processing Microencapsulación Antocianinas Ericaceae Actividad antihipertensiva Panes fortificados Microencapsulation Anthocyanins Ericaceae Antihypertensive activity Fortified breads
dc.subject.lemb.spa.fl_str_mv	Industrias alimenticias Procesos agrícolas
dc.subject.lemb.eng.fl_str_mv	Food industry and trade Agricultural processing
dc.subject.proposal.spa.fl_str_mv	Microencapsulación Antocianinas Ericaceae Actividad antihipertensiva Panes fortificados
dc.subject.proposal.eng.fl_str_mv	Microencapsulation Anthocyanins Ericaceae Antihypertensive activity Fortified breads
description	ilustraciones, diagramas, fotografías a color
publishDate	2023
dc.date.accessioned.none.fl_str_mv	2023-08-22T16:49:59Z
dc.date.available.none.fl_str_mv	2023-08-22T16:49:59Z
dc.date.issued.none.fl_str_mv	2023-04-03
dc.type.spa.fl_str_mv	Trabajo de grado - Maestría
dc.type.driver.spa.fl_str_mv	info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv	info:eu-repo/semantics/acceptedVersion
dc.type.content.spa.fl_str_mv	Text
dc.type.redcol.spa.fl_str_mv	http://purl.org/redcol/resource_type/TM
status_str	acceptedVersion
dc.identifier.uri.none.fl_str_mv	https://repositorio.unal.edu.co/handle/unal/84585
dc.identifier.instname.spa.fl_str_mv	Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv	Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv	https://repositorio.unal.edu.co/
url	https://repositorio.unal.edu.co/handle/unal/84585 https://repositorio.unal.edu.co/
identifier_str_mv	Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv	spa
language	spa
dc.relation.references.spa.fl_str_mv	AACCI. (2001). International Approved Methods of Analysis (11th ed.). St. Paul, MN, U.S.A.: Cereals & Grains Association. First approval October 17. Agudelo, C. D., Luzardo-Ocampo, I., Campos-Vega, R., Loarca-Pina, G., & Maldonado-Celis, M. E. (2018). Bioaccessibility during in vitro digestion and antiproliferative effect of bioactive compounds from Andean Berry (Vaccinium meridionale Swartz) juice. Journal of Agricultural and Food Chemistry, 66(28), 7358–7366 https://doi.org/10.1021/acs.jafc.8b01604 Agronet, MinAgricultura. Evaluaciones Agropecuarias Municipales -EVA- Oficina de Planeación y Prospectiva. (2020). Área, Producción y Rendimiento nacional de agraz. MADR. https://www.agronet.gov.co/estadistica/Paginas/home.aspx?cod=1 Consultado enero 2023. Al-Awwadi, N. A., Araiz, C., Bornet, A., Delbosc, S., Cristol, J.-P., Linck, N., Azay, J., Teissedre, P-. L., & Cros, G. (2005). Extracts enriched in different polyphenolic families normalize increased cardiac NADPH oxidase expression while having differential effects on insulin resistance, hypertension, and cardiac hypertrophy in high-fructose-fed rats. Journal of Agricultural and Food Chemistry, 53(1), 151–157. https://doi.org/10.1021/jf048919f Altuntas, M., Yilmaz, H., & Guner, A. E. (2021). Evaluation of patients with COVID-19 diagnosis for chronic diseases. Virology Journal, 18(57). https://doi.org/10.1186/s12985-021-01524-0 Antunes-Ricardo, M., Gutiérrez-Uribe, J. A., Martínez-Vitela, C., & Serna-Saldívar, S. O. (2015). Topical anti-inflammatory effects of isorhamnetin glycosides isolated from Opuntia ficus-indica. BioMed Research International, Article 847320, 9 pages. https://doi.org/10.1155/2015/847320 AOAC - (2019). Official Methods of Analysis of AOAC International, 21st ed. Gaithersburg, USA: Association of Official Analytical Chemists. https://www.aoac.org/official-methods-of-analysis-21st-edition-2019/ Arita, Y., Kihara, S., Ouchi, N., Takahashi, M., Maeda, K., Miyagawa, J. I., Hotta, K., Shimomura, I., Nakamura, T., Miyaoka, K., Kuriyama, H., Nishida, M., Yamashita, S., Okubo, K., Matsubara, K., Muraguchi, M., Ohmoto, Y., Funahashi, T., & Matsuzawa, Y. (1999). Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochemical and Biophysical Research Communications, 257(1), 79–83. https://doi.org/10.1006/bbrc.1999.0255 Arteaga Llona, A. (2006). El índice glicémico. Una controversia actual. Nutrición Hospitalaria, 21(Suppl. 2), 55–60. Bai, F., Pang, X-F., Zhang, L-H., Wang, N-P., McKallip, R.J., Garner, R.E, & Zhao, Z-Q. (2016). Angiotensin II AT1 receptor alters ACE2 activity, eNOS expression and CD44-hyaluronan interaction in rats with hypertension and myocardial fibrosis. Life Sciences, 153, 141-152. https://doi.org/10.1016/j.lfs.2016.04.013 Baranzelli, J., Kringel, D. H., Colussi, R., Fernandes Paiva, F., Camargo Aranha, B., Zavariz de Miranda, M., Zavareze, E. R., Guerra Dias, A. R. Changes in enzymatic activity, technological quality, and gamma-aminobutyric acid (GABA) content of wheat flour as affected by germination. LWT, 2018, 90, 483-490. https://doi.org/10.1016/j.lwt.2017.12.070 Bell, D. R., & Gochenaur, K. (2006). Direct vasoactive and vasoprotective properties of anthocyanin-rich extracts. Journal of Applied Physiology, 100(4), 1164–1170. https://doi.org/10.1152/japplphysiol.00626.2005 Borkowski, T., Szymusiak, H., Gliszczyńska-Świgło, A., Rietjens, I. M. C. M., & Tyrakowska, B. (2005). Radical scavenging capacity of wine anthocyanins is strongly pH-dependent. Journal of Agricultural and Food Chemistry, 53(14), 5526–5534. https://doi.org/10.1021/jf0478556 Braga, V., Rocha Guidi, L., Corrêa de Santana, R., & Zotarelli, M. F. (2020). Production and characterization of pineapple-mint juice by spray drying. Powder Technology, 375, 409 – 419. https://doi.org/10.1016/j.powtec.2020.08.012 Bukhari, S. A., Shamshari, W. A., Ur-Rahman, M., Zia-Ul-Haq, M., & Jaafar, H. Z. E. (2014). Computer-aided screening of secreted frizzled-related protein 4 (SFRP4): A potential control for Diabetes Mellitus. Molecules, 19(7), 10129–10136. https://doi.org/10.3390/molecules190710129 Caballero, P. A., Gómez, M., & Rosell, C. M. (2007). Improvement of dough rheology, bread quality and bread shelf-life by enzymes combination. Journal of Food Engineering, 81(1), 42–53. https://doi.org/10.1016/J.JFOODENG.2006.10.007 Cadioli, M. G. B., Rodas, M. A. B., Garbelotti, M. L., Marciano, E., & Taipina, M. S. (2011). Development and nutritional composition and sensory comparison between acceptance and bread traditional high soy protein and soluble prebiotic fiber. Procedia Food Science, 1, 1980–1986. https://doi.org/10.1016/J.PROFOO.2011.09.291 Chalker-Scott, L. (1999). Environmental significance of anthocyanins in plant stress responses. Photochemistry and Photobiology, 70(1), 1-9. https://doi.org/10.1111/j.1751-1097.1999.tb01944.x Chaparro de Valencia, M. L & Becerra de Lozano, N. (1995). Anatomía del fruto del “Agraz” Vaccinium meridionale Swartz. Acta Biológica Colombiana, 2(9), 159–172. COVID-19 Map - Johns Hopkins Coronavirus Resource Center. (n.d.). Consultado enero 2023, from https://coronavirus.jhu.edu/map.html da Costa, C., Horton, D., & Margolis, S. (2000). Analysis of anthocyanins in foods by liquid chromatography, liquid chromatography–mass spectrometry and capillary electrophoresis. Journal of Chromatography A, 881(1-2), 403-410. https://doi.org/10.1016/s0021-9673(00)00328-9 DeFelice S.L. FIM Rationale and Proposed Guidelines for the Nutraceutical Research & Education Act-NREA, (2002). Foundation for Innovation in Medicine. http://www.fimdefelice.org/archives/arc.researchact.html. De Pergola, G., Maldera, S., Tartagni, M., Pannacciulli, N., Loverro, G., & Giorgino, R. (2006). Inhibitory effect of obesity on gonadotropin, estradiol, and inhibin B levels in fertile women. Obesity, 14(11), 1954-1960. Delgado-Vargas, F., & Paredes-Lopez, O. (2002). Natural Colorants for Food and Nutraceutical Uses. CRC Press, Boca Raton, USA. https://www.researchgate.net/publication/329322162 Dojindo Molecular Technologies Inc. (2023) ACE Kit - WST Technical Manual. Disponible online en https://www.dojindo.eu.com/TechnicalManual/Manual_A502.pdf Dolkar, D., Bakshi, P., Wali, V. K., Sharma, V., Shat, R. A. (2017). Fruits as nutraceuticals. Ecology, Environment and Conservation, 23 (2), S113-S118. Doyon, M., & Labrecque, J. A. (2008). Functional foods: A conceptual definition. British Food Journal, 110 (11), 1133–1149. https://doi.org/10.1108/00070700810918036 Ellwood, L., Torun, G., Bahar, Z., & Fernandez, R. (2018). Effectiveness of flavonoid rich fruits for hypertension in adults: A systematic review protocol. JBI Database of Systematic Reviews and Implementation Reports, 16(11), 2103–2108. https://doi.org/10.11124/JBISRIR-2017-003804 Englyst, H. N., Kingman, S. M., Cummings, J. H. (1992). Classification and measurement of nutritionally important starch fractions. European Journal of Clinical Nutrition, 46, Suppl. 2, S33-S50. PMID: 1330528. Estupiñan-Amaya, M., Fuenmayor, C.A., &López-Córdoba, A. (2022). Evaluation of mixtures of maltodextrin and gum Arabic for the encapsulation of Andean blueberry (Vaccinium meridionale) juice by freeze–drying. International Journal of Food Science Technology, 57, 7379-7390. https://doi.org/10.1111/ijfs.16093 Ferro, D. M., Oliveira Müller, C. M., & Salvador Ferreira, S.R. (2020). Photostability and characterization of spray-dried maltodextrin powders loaded with Sida rhombifolia extract. Biocatalysis and Agricultural Biotechnology, 27, 101716. https://doi.org/10.1016/j.bcab.2020.101716 Flores, F. P., Singh, R. K., Kerr, W. L., Pegg, R. B., & Kong, F. Total phenolics content and antioxidant capacities of microencapsulated blueberry anthocyanins during in vitro digestion. Food Chemistry,153, 272–278, https://doi.org/10.1016/j.foodchem.2013.12.063 Forero, D. P., Masatani, C., Fujimoto, Y., Coy-Barrera, E., Peterson, D. G., & Osorio, C. (2016). Spermidine derivatives in lulo (Solanum quitoense Lam.) fruit: Sensory (taste) versus biofunctional (ACE-inhibition) properties. Journal of Agricultural and Food Chemistry, 64(26), 5375–5383. https://doi.org/10.1021/acs.jafc.6b01631 Franco Tobón, Y. N., Rojano, B., Alzate Arbeláez, A. F., Restrepo Florez, C. E., Rivero Barrios, D. M., & Maldonado Celis, M. E. (2016). Efecto del tiempo de almacenamiento sobre propiedades fisicoquímicas y antioxidantes de productos derivados del fruto agraz (Vaccinium meridionale Swartz). Vitae, 23(3), 184–193. https://doi.org/10.17533/udea.vitae.v23n3a04 Fujita, A., Sarkar, D., Genovese, M. I., & Shetty, K. (2017). Improving anti-hyperglycemic and anti-hypertensive properties of camu-camu (Myriciaria dubia Mc. Vaugh) using lactic acid bacterial fermentation. Process Biochemistry, 59 (Part B), 133–140. https://doi.org/10.1016/j.procbio.2017.05.017 García, J. M., Giuffrida, D., Dugo, P., Mondello, L., & Osorio, C. (2018). Development and characterisation of carotenoid-rich microencapsulates from tropical fruit by-products and yellow tamarillo (Solanum betaceum Cav.). Powder Technology, 339, 702–709. https://doi.org/10.1016/J.POWTEC.2018.08.061 Garvin, M. R., Alvarez, C., Miller, J. I., Prates, E. T., Walker, A. M., Amos, B. K., Mast, A. E., Justice, A., Aronow, B., & Jacobson, D. (2020). A mechanistic model and therapeutic interventions for Covid-19 involving a RAAS-mediated bradykinin storm. eLife, 9, 1–16. https://doi.org/10.7554/eLife.59177 Garzón, G. A., Narváez, C. E., Riedl, K. M., & Schwartz, S. J. (2010). Chemical composition, anthocyanins, non-anthocyanin phenolics and antioxidant activity of wild bilberry (Vaccinium meridionale Swartz) from Colombia. Food Chemistry, 122(4), 980–986. https://doi.org/10.1016/j.foodchem.2010.03.017 Gharsallaoui, A., Roudaut, G., Chambin, O., Voilley, A., & Saurel, R. (2007). Applications of spray-drying in microencapsulation of food ingredients: An overview. Food Research International, 40(9), 1107-1121. https://doi.org/10.1016/j.foodres.2007.07.004 González, M., Samudio, I., Sequeda-Castañeda, L. G., Celis, C., Iglesias, J., & Morales, L. (2017). Cytotoxic and antioxidant capacity of extracts from Vaccinium meridionale Swartz (Ericaceae) in transformed leukemic cell lines. Journal of Applied Pharmaceutical Science, 7(3), 24–30. https://doi.org/10.7324/JAPS.2017.70305 Goñi, I., García-Alonso, A., & Saura-Calixto, F. (1997). A starch hydrolysis procedure to estimate glycemic index. Nutrition Research, 17(3), 427-437. https://doi.org/10.1016/S0271-5317(97)00010-9 Grace, M. H., Ribnicky, D. M., Kuhn, P., Poulev, A., Logendra, S., Yousef, G. G., Raskin, I., & Lila, M. A. (2009a). Hypoglycemic activity of a novel anthocyanin-rich formulation from lowbush blueberry, Vaccinium angustifolium Aiton. Phytomedicine, 16(5), 406–415. https://doi.org/10.1016/j.phymed.2009.02.018 Haldar, R. N. (2013). Global brief on hypertension: Silent killer, global public health crisis. Indian Journal of Physical Medicine and Rehabilitation, 24(1), 2–2 https://doi.org/10.5005/ijopmr-24-1-2 Hämäläinen, M., Nieminen, R., Vuorela, P., Heinonen, M., & Moiianen, E. (2007). Anti-inflammatory effects of flavonoids: Genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappaB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappaB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages. Mediators of Inflammation, 45673. https://doi.org/10.1155/2007/45673 Herrera, C., Bolaños, N., & Lutz, G. (2003). Química de Alimentos. Manual de Laboratorio. (pp. 3). San José, Costa Rica: Editorial Universidad de Costa Rica. Hossain, G., Javed, A., Akter, S., & Saha, S. (2021). SARS-CoV-2 host diversity: An update of natural infections and experimental evidence. Journal of Microbiology, Immunology and Infection, 54(2), 175-181. https://doi.org/10.1016/j.jmii.2020.06.006 Hou, D-. X., Yanagita, T., Uto, T., Masuzaki, S., & Fujii, M. (2005). Anthocyanidins inhibit cyclooxygenase-2 expression in LPS-evoked macrophages: Structure-activity relationship and molecular mechanisms involved. Biochemical Pharmacology, 70(3), 417–425. https://doi.org/10.1016/j.bcp.2005.05.003 Isaza, J. H., Ito, H., & Yoshida, T. (2004). Oligomeric hydrolyzable tannins from Monochaetum multiflorum. Phytochemistry, 65(3), 359–367. https://doi.org/10.1016/j.phytochem.2003.11.017 Jenkins, D. J., Wolever, T. M., Taylor, R. H., Barker, H., Fielden, H., Baldwin, J. M., Bowling, A. C., Newman, H. C., Jenkins, A. L., & Goff, D. V. (1981). Glycemic index of foods: a physiological basis for carbohydrate exchange. The American Journal of Clinical Nutrition, 34(3), 362-366. https://academic.oup.com/ajcn/article-abstract/34/3/362/4692881 Kamei, H., Kojima, T., Hasegawa, M., Koide, T., Umeda, T., Yukawa, T., & Terabe, K. (1995). Suppression of tumor cell growth by anthocyanins in vitro. Cancer Investigation, 13(6), 590-594. Kim, J. N., Han, S. N., Ha, T. J., & Kim, H-. K. (2017). Black soybean anthocyanins attenuate inflammatory responses by suppressing reactive oxygen species production and mitogen activated protein kinases signaling in lipopolysaccharide-stimulated macrophages. Nutrition Research and Practice, 11(5), 357–364. https://doi.org/10.4162/nrp.2017.11.5.357 Kong, J. M., Chia, L. S., Goh, N. K., Chia, T. F., & Brouillard, R. (2003). Analysis and biological activities of anthocyanins. Phytochemistry, 64(5), 923–933. https://doi.org/10.1016/S0031-9422(03)00438-2 Lazo-Vélez, M. A., Gutiérrez-Díaz, V. A., Ramírez-Medrano, A., & Serna-Saldívar, S. O. (2013). Effect of sodium selenite addition and sponge dough fermentation on selenomethionine generation during production of yeast-leavened breads. Journal of Cereal Science, 58(1), 164–169. https://doi.org/10.1016/J.JCS.2013.03.019 Ligarreto, G. A. (2009). Perspectivas del cultivo de agraz o mortiño (Vaccinium meridionale Swartz) en la zona altoandina de Colombia. 1st Ed. Bogotá: Gente Nueva Editorial. López-Barrios, L., Antunes-Ricardo, M., & Gutiérrez-Uribe, J. A. (2016). Changes in antioxidant and antiinflammatory activity of black bean (Phaseolus vulgaris L.) protein isolates due to germination and enzymatic digestion. Food Chemistry, 203, 417–424. https://doi.org/10.1016/J.FOODCHEM.2016.02.048 López-Vidaña, E. C., Pilatowsky Figueroa, I., Cortés, F. B., Rojano, B. A., & Navarro Ocaña, A. (2017). Effect of temperature on antioxidant capacity during drying process of mortiño (Vaccinium meridionale Swartz). International Journal of Food Properties, 20(2), 294–305. https://doi.org/10.1080/10942912.2016.1155601 Maldonado Celis, M. E.; Franco Tobón, Y. N.; Agudelo, C.; Arango, S. S. & Rojano, B. (2017) Andean berry (Vaccinium meridionale Swartz). En Fruit and Vegetable Phytochemicals: Chemistry and Human Health, 2nd ed.; Yahia, E. M. Ed.; Wiley-Blackwell, Volume II, pp 869-882. Marín-Echeverri, C., Blesso, C. N., Fernández, M. L., Galvis-Pérez, Y., Ciro-Gómez, G., Núñez-Rangel, V., Aristizábal, J. C., & Barona-Acevedo, J. (2018). Effect of agraz (Vaccinium meridionale Swartz) on high-density lipoprotein function and inflammation in women with metabolic syndrome. Antioxidants, 7(12), 185. https://doi.org/10.3390/antiox7120185 Marín-Sánchez, A. (2020). Características clínicas básicas en los primeros 100 casos fatales de COVID-19 en Colombia. Revista Panamericana de Salud Pública, 44(1), 1-4. https://doi.org/10.26633/RPSP.2020.87 Mata-Ramírez, D., Serna-Saldívar, S. O., Villela-Castrejón, J., Villaseñor-Durán, M. C., & Buitimea-Cantúa, N. E. (2018). Phytochemical profiles, dietary fiber and baking performance of wheat bread formulations supplemented with Roselle (Hibiscus sabdariffa). Journal of Food Measurement and Characterization, 12(4), 2657–2665. https://doi.org/10.1007/s11694-018-9883-4 Mckeown, N. M., Meigs, J. B., Liu, S., Saltzman, E., Wilson, P. W. F., & Jacques, P. F. (2004). Carbohydrate nutrition, insulin resistance, and the prevalence of the metabolic syndrome in the Framingham offspring cohort. Diabetes Care, 27(2), 538-546. https://doi.org/10.2337/diacare.27.2.538 Meléndez-Martínez, A. J., Vicario, I. M., & Heredia, F. J. (2003). Application of tristimulus colorimetrý to estimate the carotenoids content in ultrafrozen orange juices. Journal of Agricultural and Food Chemistry, 51 (25), 7266-7270. https://doi.org/10.1021/jf034873z Miguel, M. G. (2011). Anthocyanins: Antioxidant and/or anti-inflammatory activities. Journal of Applied Pharmaceutical Sciences, 1(6), 7-15. Milán-Noris, A. K., de la Rosa-Millán, J., Reyes-Moreno, C., Serna-Saldivar, S. O. (2017) Physicochemical, functional properties, and digestion of isolated starches from pigmented chickpea (Cicer arietinum L.) cultivars. Starch-Stärke, 69, 1600152, https://doi.org/10.1002/star.201600152 Mills, K. T., Bundy, J. D., Kelly, T. N., Reed, J. E., Kearney, P. M., Reynolds, K., Chen, J., & He, J. (2016). Global disparities of hypertension prevalence and control. Circulation, 134(6), 441–450. https://doi.org/10.1161/CIRCULATIONAHA.115.018912 Mora, A. C. (2016). Comunicación personal de la Secretaría de Fomento Agropecuario de Boyacá. Miyazaki, M., Maeda, T., & Morita, N. (2004) Effect of various dextrin substitutions for wheat flour on dough properties and bread qualities. Food Research International, 37(1), 59-65. https://doi.org/10.1016/j.foodres.2003.08.007 Muniyappa, R., & Gubbi, S. (2020). COVID-19 pandemic, coronaviruses, and diabetes mellitus. American Journal of Physiology-Endocrinology and Metabolism, 318(5), E736-E741. https://doi.org/10.1152/ajpendo.00124.2020 Onder, G., Rezza, G., & Brusaferro, S. (2020). Case-fatality rate and characteristics of patients dying in Relation to COVID-19 in Italy. JAMA - Journal of the American Medical Association, 323 (18), 1775–1776. https://doi.org/10.1001/jama.2020.4683 Onslow, M. W. (2014). The Anthocyanin Pigments of Plants. Cambridge, University Press. https://doi.org/10.5962/bhl.title.1687 Onyango, C. (2016). Starch and modified starch in bread making: A review. African Journal of Food Science, 10(12), 344–351. https://doi.org/10.5897/ajfs2016.1481 Osorio, C., Forero, D.P., Carrizo, J. G. (2011). Characterisation and performance assessment of guava (Psidium guajava L.) microencapsulates obtained by spray-drying. Food Research International, 44(5), 1174-1181. https://doi.org/10.1016/j.foodres.2010.09.007 Parichatikanond, W., Pinthong, D., & Mangmool, S. (2012). Blockade of the renin-angiotensin system with delphinidin, cyanin, and quercetin. Planta Medica, 78(15), 1626–1632. https://doi.org/10.1055/s-0032-1315198 Ramírez-Sagredo, A., Ramírez-Reyes, A., Ocaranza, M. P., Chiong, M., Riquelme, J. A., Jalil, J. E., & Lavandero, S. (2020). Antihipertensivos en pacientes con COVID-19. Revista Chilena de Cardiología, 39(1), 66–74. https://doi.org/10.4067/s0718-85602020000100066 Revelo, D. (2014). Microencapsulación de tomate de árbol rojo (Solanum betaceum Cav.), mediante spray-drying para aplicación en productos lácteos. Tesis de Maestría en Ciencia y Tecnología de Alimentos. [Universidad Nacional de Colombia - Sede Bogotá]. https://repositorio.unal.edu.co/handle/unal/51865 Riaz, M., Zia-Ul-Haq, M., & Saad, B. (2016). The role of anthocyanins in obesity and diabetes. En: Anthocyanins and Human Health: Biomolecular and Therapeutic Aspects. Springer; pags. 109-123. Rincón Soledad, M. C., Buitrago Guacaneme, M. C., Ligarreto Moreno, G. A., Torres Aponte, W. S., & Balaguera López H. E. (2012). Behavior of agraz fruit (Vaccinium meridionale Swartz) harvested in different maturity stages and stored under refrigeration. Revista de la Facultad Nacional de Agronomía de Medellín, 65(2), 6615-6625 https://repositorio.unal.edu.co/handle/unal/71822 Rodríguez C, A, Chamorro, F. J., Henao, M., Ospina, R., Nates, G., & Calderón, L. V. (2018). Polinización por abejas en cultivos promisorios de Colombia: agraz (Vaccidium meridionale), chamba (Campomanesia lineatifolia) y cholupa (Passiflora maliformis). Bogotá, Colombia. Universidad Nacional de Colombia. 146 p. Rossi, A., Serraino, I., Dugo, P., di Paola, R., Mondello, L., Genovese, T., Morabito, D., Dugo, G., Sautebin, L., Caputi, A. P., & Cuzzocrea, S. (2003). Protective effects of anthocyanins from blackberry in a rat model of acute lung inflammation. Free Radical Research 37(8), 891–900. https://doi.org/10.1080/1071576031000112690 Salmer, J., Manson, J. E., Stampfer, M. J., Colditz, G. A., Wing, A. L., & Willett, W. C. (1997). Dietary fiber, glycemic load, and risk of NIDDM in men. http://jama.jamanetwork.com/ Sánchez-Gloria, J. L., Osorio-Alonso, H., Arellano-Buendía, A. S., Carbó, R., Hernández-Díazcouder, A., Guzmán-Martín, C. A., Rubio-Gayosso, I., & Sánchez-Muñoz, F. (2020). Nutraceuticals in the treatment of pulmonary arterial hypertension. International Journal of Molecular Sciences, 21(14), 1–35. https://doi.org/10.3390/ijms21144827 Sandhu, K. S., Lim, S.-T.(2008), Digestibility of legume starches as influenced by their physical and structural properties. Carbohydrate polymers 2008, 71, 245-252. Seeram, N. P., Momin, R. A., Nair, M. G., & Bourquin, L. D. (2001). Cyclooxygenase inhibitory and antioxidant cyanidin glycosides in cherries and berries. Phytomedicine, 8(5), 362–369. https://doi.org/10.1078/0944-7113-00053 Sharma, J. N., Al-Omran, A., & Parvathy, S. S. (2007). Role of nitric oxide in inflammatory diseases. Inflammopharmacology, 15 (6), 252–259. https://doi.org/10.1007/s10787-007-0013-x Shih, P. H., Yeh, Ch.-T., & Yen, G-C. (2005). Effects of anthocyanidin on the inhibition of proliferation and induction of apoptosis in human gastric adenocarcinoma cells. Food and Chemical Toxicology, 43(10), 1557–1566. https://doi.org/10.1016/j.fct.2005.05.001 Sigma-Aldrich Co. (2023). Technical Bulletin -Glucosidase Activity Assay Kit. Catalog number MAK123. Disponible on line en: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/286/096/mak123bul.pdf Singleton, V. L., Rossi, J. A. (1965). Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. American Journal of Enology and Viticulture, 16 (3), 144-158. https://www.ajevonline.org/content/16/3/144 Siró, I., Kápolna, E., Kápolna, B., & Lugasi, A. (2008). Functional food. Product development, marketing and consumer acceptance-A review. Appetite, 51(3), 456–467. https://doi.org/10.1016/j.appet.2008.05.060 Steffen, Y., Gruber, C., Schewe, T., & Sies, H. (2008). Mono-O-methylated flavanols and other flavonoids as inhibitors of endothelial NADPH oxidase. Archives of Biochemistry and Biophysics, 469(2), 209–219. https://doi.org/10.1016/j.abb.2007.10.012 Stintzing, F., & Carle, R. (2004). Functional properties of anthocyanins and betalains in plants, food, and in human nutrition. Trends In Food Science & Technology, 15(1), 19-38. https://doi.org/10.1016/j.tifs.2003.07.004 Sultan, M. T., Butt, M. S., Karim, R., Iqbal, S. Z., Ahmad, S., Zia-Ul-Haq, M., Aliberti, L., Ahmad, A. N., & De Feo, V. (2014a). Effect of Nigella sativa fixed and essential oils on antioxidant status, hepatic enzymes, and immunity in streptozotocin induced diabetes mellitus. BMC Complementary and Alternative Medicine, 14: 193. https://doi.org/10.1186/1472-6882-14-193 Sultan, M. T., Butt, M. S., Karim, R., Zia-Ul-Haq, M., Batool, R., Ahmad, S., Aliberti, L., & de Feo, V. (2014b). Nigella sativa fixed and essential oil supplementation modulates hyperglycemia and allied complications in streptozotocin-induced Diabetes Mellitus. Evidence-Based Complementary and Alternative Medicine, 2014. https://doi.org/10.1155/2014/826380 Takikawa, M., Inoue, S., Horio, F., & Tsuda, T. (2010). Dietary anthocyanin-rich bilberry extract ameliorates hyperglycemia and insulin sensitivity via activation of amp-activated protein kinase in diabetic mice. The Journal of Nutrition, 140(3), 527–533. https://doi.org/10.3945/jn.109.118216 Toufektsian, M. -C., de Lorgeril, M., Nagy, N., Salen, P., Donati, M. B., Giordano, L., Mock, H. -P., Peterek, S., Matros, A., Petroni, K., Pilu, R., Rotilio, D., Tonelli, C., de Leiris, J., Boucher, F., & Martin, C. (2008). Chronic dietary intake of plant-derived anthocyanins protects the rat heart against ischemia-reperfusion injury. Journal of Nutrition, 138(4), 747–752. https://doi.org/10.1093/jn/138.4.747 Vasco, C., Rihinen, K., Ruales, J., & Kamal-Eldin, A. (2009). Chemical composition and phenolic compound profile of Mortiño (Vaccinium floribundum Kunth). Journal of Agricultural and Food Chemistry, 57, (18), 8274-8281. https://doi.org/10.1021/jf9013586 Vallejo, D. A. (2000). Fomento al mortiño (Vaccinium meridionale) como especie promisoria del Parque Regional Arví. Corantioquia, Medellín Valls, J., Millán, S., Martí, M. P., Borrás, E., & Arola, L. (2009). Advanced separation methods of food anthocyanins, isoflavones and flavanols. Journal of Chromatography A, 1216, 7143–7172. https://doi.org/10.1016/j.chroma.2009.07.030 Vendrame, S. & Klimis-Zacas, D. (2019). Potential factors influencing the effects of anthocyanins on blood pressure regulation in humans: A review. Nutrients, 11(6). https://doi.org/10.3390/nu11061431 Villacrez, J. L., Carriazo, J. G., & Osorio, C. (2014). Microencapsulation of Andes berry (Rubus glaucus Benth.) aqueous extract by spray drying. Food and Bioprocess Technology, 7(5), 1445–1456. https://doi.org/10.1007/s11947-013-1172-y Villasante, J., Espinosa-Ramírez, J., Pérez-Carrillo, E., Heredia-Olea, E., Metón, I., Almajano, M. P. (2022). Evaluation of non-extruded and extruded pecan (Carya illinoinensis) shell powder as functional ingredient in bread and wheat tortilla. LWT, 160, 113299. https://doi.org/10.1016/j.lwt.2022.113299 Wang, H., Nair, M. G., Strasburg, G. M., Chang, Y-. Ch., Booren, A. M., Gray, J. I., & DeWitt, D. L. (1999). Antioxidant and antiinflammatory activities of anthocyanins and their aglycon, cyanidin, from tart cherries. Journal of Natural Products, 62(2), 294–296. https://doi.org/10.1021/np980501m. Wang, Q., Tang, X. N., & Yenari, M. A. (2007). The inflammatory response in stroke. Journal of Neuroimmunology, 184 (1-2), 53-68. https://doi.org/10.1016/j.jneuroim.2006.11.014 Wang, X., Jiang, Y., Wang, Y-. W., Huang, M-. T., Ho, C. T., & Huang, Q. (2008). Enhancing anti-inflammation activity of curcumin through O/W nanoemulsions. Food Chemistry, 108(2), 419–424. https://doi.org/10.1016/j.foodchem.2007.10.086 Whelton, P. K., Carey, R. M., & Aronow, W. S. (2021). ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: A report of the American College of Cardiology/American Heart Association. Task Force on Clinical Practice. KIDNEYS, 7(1), 68–74. https://doi.org/10.22141/2307-1257.7.1.2018.122220 Witczak, M., Korus, J., Ziobro, R., & Juszczak, L. (2010). The effects of maltodextrins on gluten-free dough and quality of bread. Journal of Food Engineering, 96(2), 258-265. https://doi.org/10.1016/j.jfoodeng.2009.07.022 Yang, J., Zheng, Y., Gou, X., Pu, K., Chen, Z., Guo, Q., Ji, R., Wang, H., Wang, Y., & Zhou, Y. (2020a). Journal Pre-proof Prevalence of comorbidities in the novel Wuhan coronavirus (COVID-19) infection: a systematic review and meta-analysis. International Journal of Infectious Diseases, 94, 91-95. https://doi.org/10.1016/j.ijid.2020.03.017 Yang, X., Yu, Y., Xu, J., Shu, H., Xia, J., Liu, H., Wu, Y., Zhang, L., Yu, Z., Fang, M., Yu, T., Wang, Y., Pan, S., Zou, X., Yuan, S., & Shang, Y. (2020b). Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. The Lancet Respiratory Medicine, 8(5), 475–481. https://doi.org/10.1016/S2213-2600(20)30079-5 Yang, M., I. Koo, S., O. Song, W., & K. Chun, O. (2011). Food matrix affecting anthocyanin bioavailability: Review. Current Medicinal Chemistry, 18(2), 291–300. https://doi.org/10.2174/092986711794088380 Zapata, I. C., Álzate, A. F., Zapata, K., Arias, J. P., Puertas, M. A., & Rojano, B. (2019). Effect of pH, temperature and time of extraction on the antioxidant properties of Vaccinium meridionale Swartz. Journal of Berry Research, 9(1), 39–49. https://doi.org/10.3233/JBR-18299
dc.rights.coar.fl_str_mv	http://purl.org/coar/access_right/c_abf2
dc.rights.license.spa.fl_str_mv	Atribución-NoComercial-SinDerivadas 4.0 Internacional
dc.rights.uri.spa.fl_str_mv	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.accessrights.spa.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	Atribución-NoComercial-SinDerivadas 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv	openAccess
dc.format.extent.spa.fl_str_mv	xviii, 82 páginas
dc.format.mimetype.spa.fl_str_mv	application/pdf
dc.publisher.spa.fl_str_mv	Universidad Nacional de Colombia
dc.publisher.program.spa.fl_str_mv	Bogotá - Ciencias Agrarias - Maestría en Ciencia y Tecnología de Alimentos
dc.publisher.faculty.spa.fl_str_mv	Facultad de Ciencias Agrarias
dc.publisher.place.spa.fl_str_mv	Bogotá, Colombia
dc.publisher.branch.spa.fl_str_mv	Universidad Nacional de Colombia - Sede Bogotá
institution	Universidad Nacional de Colombia
bitstream.url.fl_str_mv	https://repositorio.unal.edu.co/bitstream/unal/84585/1/license.txt https://repositorio.unal.edu.co/bitstream/unal/84585/2/1031157610_2023.pdf https://repositorio.unal.edu.co/bitstream/unal/84585/3/1031157610_2023.pdf.jpg
bitstream.checksum.fl_str_mv	eb34b1cf90b7e1103fc9dfd26be24b4a f041cc873d8e5ebb067a94626ee82d7b 1dc30fae3b19b1500f30d7335efc38c9
bitstream.checksumAlgorithm.fl_str_mv	MD5 MD5 MD5
repository.name.fl_str_mv	Repositorio Institucional Universidad Nacional de Colombia
repository.mail.fl_str_mv	repositorio_nal@unal.edu.co
_version_	1806886173377822720
spelling	Atribución-NoComercial-SinDerivadas 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Osorio Roa, Coralia502cafdbd9cf75b1d51ce5b7133722a1Otalora, María Carolina3705fda4ca0be5f88191815fcd80bdd5Amaya Gómez, Andrés Mauricio53086b039ed8b515a96998bbb0137980Grupo Aditivos Naturales de Aroma y ColorganacAmaya, Andres Mauricio [0009-0009-4689-4859]2023-08-22T16:49:59Z2023-08-22T16:49:59Z2023-04-03https://repositorio.unal.edu.co/handle/unal/84585Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, diagramas, fotografías a colorLos frutos de agraz (Vaccinium meridionale Swartz) se caracterizaron fisicoquímicamente y se obtuvo un extracto polar con acetona-agua, el cual se fraccionó por partición con solventes de polaridad creciente. El contenido de fenoles totales, la inhibición de las enzimas α-glucosidasa y α-amilasa para determinar la actividad antihiperglicémica in vitro, y la inhibición de la enzima angiotensina-1 (ACE-1) para determinar actividad antihipertensiva in vitro, se midieron en la fruta liofilizada, así como en las fracciones más polares de agraz. Con estos resultados se evidenció que el agraz tiene potencial como inhibidor de la ACE-1 y que algunos de los compuestos responsables de dicha actividad son las antocianinas, específicamente derivados de delfinidina, que fueron identificados por análisis por HPLC-MS. Posteriormente se desarrollaron cuatro microencapsulados de la fruta por spray-drying, usando maltodextrina (MD) como agente encapsulante. Se evaluaron las características fisicoquímicas, morfológicas, térmicas y biofuncionales de los microencapsulados obtenidos a dos temperaturas de entrada (120 °C y 150 °C) y dos mezclas de alimentación (fruta: MD, 1:1 y 2:3, p/p), encontrando que la mayor actividad antihipertensiva la tenía la muestra M3 (150 °C, 1:1). El microencapsulado M3 se incorporó en harina de trigo en diferentes proporciones (5, 10 y 15%) y la reología de las harinas compuestas se evaluó mediante el uso del equipo Mixolab®. El análisis de las propiedades reológicas mostró que la adición del microencapsulado de agraz que contenía MD afectaba las propiedades reológicas de la harina, específicamente dureza, cohesividad y resiliencia a medida que aumentaba la proporción de M3 en la harina compuesta, también el color y oscurecimiento por degradación termica de las antocianinas. Finalmente, se usó la harina con 5% de M3 (MCA 5%) para la fabricación del pan, el cual se caracterizó fisicoquímica, reológica y sensorialmente en comparación con un pan obtenido con la harina de trigo control (CTRL). En el pan obtenido con la harina de trigo compuesta, se determinó el contenido de antocianinas, el índice glicémico, la actividad antioxidante celular y la actividad antiinflamatoria in vitro evaluando la producción de óxido nítrico, después de simular la digestión en el tracto gastrointestinal. Se comprobó que las antocianinas derivadas de delfinidina y cianidina se preservaban en el pan y que la biofuncionalidad era mayor en el pan fortificado con el microencapsulado de agraz que con la harina de trigo control. Con estos resultados se comprueba la viabilidad del uso del agraz para el desarrollo de microencapsulados con propiedades biofuncionales que pueden ser usados como aditivos en diferentes matrices alimenticias. (Texto tomado de la fuente)Agraz (Vaccinium meridionale Swartz) fruits were physicochemically characterized, and a polar extract was obtained by extraction with an acetone-water mixture for further partition with solvents of increasing polarity. The total phenolic content, the α-glucosidase and α-amylase inhibition to measure in vitro antihyperglycemic activity, and the inhibition of the angiotensin-1 enzyme (ACE-1) to determine in vitro antihypertensive activity, were measured in the freeze-dried fruit and more polar fractions. These results showed that the V. meridionale fruit has potential as an ACE-1 inhibitor and the anthocyanins are one of the compounds responsible for this activity, specifically the delphinidin derivatives identified by HPLC-MS analyses. Later, four microencapsulates were obtained by spray-drying using maltodextrin (MD) as the encapsulating agent. The physicochemical, morphological, thermal and biofunctional properties of microencapsulates obtained at two inlet temperatures (120 °C and 150 °C) and two feed mixtures (fruit: MD, 1:1 and 2:3, w/w) were evaluated, finding that the sample M3 (150 °C, 1:1) showed the highest antihypertensive activity value. The microencapsulate M3 was added to wheat flour at different proportions (5, 10 and 15%) to evaluate their rheological behavior by using Mixolab equipment and selecting an adequate concentration of agraz microencapsulate. These results showed that the addition of agraz microencapsulate (containing MD) influenced the rheological properties of the flour, specifically hardness, cohesiveness, and resilience proportional to a higher M3 content. Also, the color and darkness were affected due to the thermal degradation of anthocyanins. Finally, the fortified flour with 5% of M3 (MCA 5%) were used for fortified bread preparation, and its physicochemical, rheological and sensory properties were characterized in comparison to a bread prepared with wheat flour control (CTRL). The anthocyanin content, glycemic index, cellular antioxidant activity, and nitric oxide production were evaluated in the fortified bread, after simulation of digestion through gastrointestinal tract. The presence of anthocyanins (mainly delphinidin and cyanidin derivatives) in the fortified bread was detected. Also, a higher biofunctionality was found in the bread fortified with the agraz microencapsulate than in the bread with control flour. These results suggest that the agraz could be used for the development of microencapsulates exhibiting biofunctional properties which can be used as additives for different food matrices.MaestríaMagíster en Ciencia y Tecnología de AlimentosQuímica de Alimentosxviii, 82 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Ciencias Agrarias - Maestría en Ciencia y Tecnología de AlimentosFacultad de Ciencias AgrariasBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá600 - Tecnología (Ciencias aplicadas)Industrias alimenticiasProcesos agrícolasFood industry and tradeAgricultural processingMicroencapsulaciónAntocianinasEricaceaeActividad antihipertensivaPanes fortificadosMicroencapsulationAnthocyaninsEricaceaeAntihypertensive activityFortified breadsDesarrollo de aditivos alimenticios con base en las propiedades biofuncionales del Agraz (Vaccinium meridionale Swartz)Food additives development based on biofunctional properties of agraz (Vaccinium meridionale Swartz)Trabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMAACCI. (2001). International Approved Methods of Analysis (11th ed.). St. Paul, MN, U.S.A.: Cereals & Grains Association. First approval October 17.Agudelo, C. D., Luzardo-Ocampo, I., Campos-Vega, R., Loarca-Pina, G., & Maldonado-Celis, M. E. (2018). Bioaccessibility during in vitro digestion and antiproliferative effect of bioactive compounds from Andean Berry (Vaccinium meridionale Swartz) juice. Journal of Agricultural and Food Chemistry, 66(28), 7358–7366 https://doi.org/10.1021/acs.jafc.8b01604Agronet, MinAgricultura. Evaluaciones Agropecuarias Municipales -EVA- Oficina de Planeación y Prospectiva. (2020). Área, Producción y Rendimiento nacional de agraz. MADR. https://www.agronet.gov.co/estadistica/Paginas/home.aspx?cod=1 Consultado enero 2023.Al-Awwadi, N. A., Araiz, C., Bornet, A., Delbosc, S., Cristol, J.-P., Linck, N., Azay, J., Teissedre, P-. L., & Cros, G. (2005). Extracts enriched in different polyphenolic families normalize increased cardiac NADPH oxidase expression while having differential effects on insulin resistance, hypertension, and cardiac hypertrophy in high-fructose-fed rats. Journal of Agricultural and Food Chemistry, 53(1), 151–157. https://doi.org/10.1021/jf048919fAltuntas, M., Yilmaz, H., & Guner, A. E. (2021). Evaluation of patients with COVID-19 diagnosis for chronic diseases. Virology Journal, 18(57). https://doi.org/10.1186/s12985-021-01524-0Antunes-Ricardo, M., Gutiérrez-Uribe, J. A., Martínez-Vitela, C., & Serna-Saldívar, S. O. (2015). Topical anti-inflammatory effects of isorhamnetin glycosides isolated from Opuntia ficus-indica. BioMed Research International, Article 847320, 9 pages. https://doi.org/10.1155/2015/847320AOAC - (2019). Official Methods of Analysis of AOAC International, 21st ed. Gaithersburg, USA: Association of Official Analytical Chemists. https://www.aoac.org/official-methods-of-analysis-21st-edition-2019/Arita, Y., Kihara, S., Ouchi, N., Takahashi, M., Maeda, K., Miyagawa, J. I., Hotta, K., Shimomura, I., Nakamura, T., Miyaoka, K., Kuriyama, H., Nishida, M., Yamashita, S., Okubo, K., Matsubara, K., Muraguchi, M., Ohmoto, Y., Funahashi, T., & Matsuzawa, Y. (1999). Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochemical and Biophysical Research Communications, 257(1), 79–83. https://doi.org/10.1006/bbrc.1999.0255Arteaga Llona, A. (2006). El índice glicémico. Una controversia actual. Nutrición Hospitalaria, 21(Suppl. 2), 55–60.Bai, F., Pang, X-F., Zhang, L-H., Wang, N-P., McKallip, R.J., Garner, R.E, & Zhao, Z-Q. (2016). Angiotensin II AT1 receptor alters ACE2 activity, eNOS expression and CD44-hyaluronan interaction in rats with hypertension and myocardial fibrosis. Life Sciences, 153, 141-152. https://doi.org/10.1016/j.lfs.2016.04.013Baranzelli, J., Kringel, D. H., Colussi, R., Fernandes Paiva, F., Camargo Aranha, B., Zavariz de Miranda, M., Zavareze, E. R., Guerra Dias, A. R. Changes in enzymatic activity, technological quality, and gamma-aminobutyric acid (GABA) content of wheat flour as affected by germination. LWT, 2018, 90, 483-490. https://doi.org/10.1016/j.lwt.2017.12.070Bell, D. R., & Gochenaur, K. (2006). Direct vasoactive and vasoprotective properties of anthocyanin-rich extracts. Journal of Applied Physiology, 100(4), 1164–1170. https://doi.org/10.1152/japplphysiol.00626.2005Borkowski, T., Szymusiak, H., Gliszczyńska-Świgło, A., Rietjens, I. M. C. M., & Tyrakowska, B. (2005). Radical scavenging capacity of wine anthocyanins is strongly pH-dependent. Journal of Agricultural and Food Chemistry, 53(14), 5526–5534. https://doi.org/10.1021/jf0478556Braga, V., Rocha Guidi, L., Corrêa de Santana, R., & Zotarelli, M. F. (2020). Production and characterization of pineapple-mint juice by spray drying. Powder Technology, 375, 409 – 419. https://doi.org/10.1016/j.powtec.2020.08.012Bukhari, S. A., Shamshari, W. A., Ur-Rahman, M., Zia-Ul-Haq, M., & Jaafar, H. Z. E. (2014). Computer-aided screening of secreted frizzled-related protein 4 (SFRP4): A potential control for Diabetes Mellitus. Molecules, 19(7), 10129–10136. https://doi.org/10.3390/molecules190710129Caballero, P. A., Gómez, M., & Rosell, C. M. (2007). Improvement of dough rheology, bread quality and bread shelf-life by enzymes combination. Journal of Food Engineering, 81(1), 42–53. https://doi.org/10.1016/J.JFOODENG.2006.10.007Cadioli, M. G. B., Rodas, M. A. B., Garbelotti, M. L., Marciano, E., & Taipina, M. S. (2011). Development and nutritional composition and sensory comparison between acceptance and bread traditional high soy protein and soluble prebiotic fiber. Procedia Food Science, 1, 1980–1986. https://doi.org/10.1016/J.PROFOO.2011.09.291Chalker-Scott, L. (1999). Environmental significance of anthocyanins in plant stress responses. Photochemistry and Photobiology, 70(1), 1-9. https://doi.org/10.1111/j.1751-1097.1999.tb01944.xChaparro de Valencia, M. L & Becerra de Lozano, N. (1995). Anatomía del fruto del “Agraz” Vaccinium meridionale Swartz. Acta Biológica Colombiana, 2(9), 159–172.COVID-19 Map - Johns Hopkins Coronavirus Resource Center. (n.d.). Consultado enero 2023, from https://coronavirus.jhu.edu/map.htmlda Costa, C., Horton, D., & Margolis, S. (2000). Analysis of anthocyanins in foods by liquid chromatography, liquid chromatography–mass spectrometry and capillary electrophoresis. Journal of Chromatography A, 881(1-2), 403-410. https://doi.org/10.1016/s0021-9673(00)00328-9DeFelice S.L. FIM Rationale and Proposed Guidelines for the Nutraceutical Research & Education Act-NREA, (2002). Foundation for Innovation in Medicine. http://www.fimdefelice.org/archives/arc.researchact.html.De Pergola, G., Maldera, S., Tartagni, M., Pannacciulli, N., Loverro, G., & Giorgino, R. (2006). Inhibitory effect of obesity on gonadotropin, estradiol, and inhibin B levels in fertile women. Obesity, 14(11), 1954-1960.Delgado-Vargas, F., & Paredes-Lopez, O. (2002). Natural Colorants for Food and Nutraceutical Uses. CRC Press, Boca Raton, USA. https://www.researchgate.net/publication/329322162Dojindo Molecular Technologies Inc. (2023) ACE Kit - WST Technical Manual. Disponible online en https://www.dojindo.eu.com/TechnicalManual/Manual_A502.pdfDolkar, D., Bakshi, P., Wali, V. K., Sharma, V., Shat, R. A. (2017). Fruits as nutraceuticals. Ecology, Environment and Conservation, 23 (2), S113-S118.Doyon, M., & Labrecque, J. A. (2008). Functional foods: A conceptual definition. British Food Journal, 110 (11), 1133–1149. https://doi.org/10.1108/00070700810918036Ellwood, L., Torun, G., Bahar, Z., & Fernandez, R. (2018). Effectiveness of flavonoid rich fruits for hypertension in adults: A systematic review protocol. JBI Database of Systematic Reviews and Implementation Reports, 16(11), 2103–2108. https://doi.org/10.11124/JBISRIR-2017-003804Englyst, H. N., Kingman, S. M., Cummings, J. H. (1992). Classification and measurement of nutritionally important starch fractions. European Journal of Clinical Nutrition, 46, Suppl. 2, S33-S50. PMID: 1330528.Estupiñan-Amaya, M., Fuenmayor, C.A., &López-Córdoba, A. (2022). Evaluation of mixtures of maltodextrin and gum Arabic for the encapsulation of Andean blueberry (Vaccinium meridionale) juice by freeze–drying. International Journal of Food Science Technology, 57, 7379-7390. https://doi.org/10.1111/ijfs.16093Ferro, D. M., Oliveira Müller, C. M., & Salvador Ferreira, S.R. (2020). Photostability and characterization of spray-dried maltodextrin powders loaded with Sida rhombifolia extract. Biocatalysis and Agricultural Biotechnology, 27, 101716. https://doi.org/10.1016/j.bcab.2020.101716Flores, F. P., Singh, R. K., Kerr, W. L., Pegg, R. B., & Kong, F. Total phenolics content and antioxidant capacities of microencapsulated blueberry anthocyanins during in vitro digestion. Food Chemistry,153, 272–278, https://doi.org/10.1016/j.foodchem.2013.12.063Forero, D. P., Masatani, C., Fujimoto, Y., Coy-Barrera, E., Peterson, D. G., & Osorio, C. (2016). Spermidine derivatives in lulo (Solanum quitoense Lam.) fruit: Sensory (taste) versus biofunctional (ACE-inhibition) properties. Journal of Agricultural and Food Chemistry, 64(26), 5375–5383. https://doi.org/10.1021/acs.jafc.6b01631Franco Tobón, Y. N., Rojano, B., Alzate Arbeláez, A. F., Restrepo Florez, C. E., Rivero Barrios, D. M., & Maldonado Celis, M. E. (2016). Efecto del tiempo de almacenamiento sobre propiedades fisicoquímicas y antioxidantes de productos derivados del fruto agraz (Vaccinium meridionale Swartz). Vitae, 23(3), 184–193. https://doi.org/10.17533/udea.vitae.v23n3a04Fujita, A., Sarkar, D., Genovese, M. I., & Shetty, K. (2017). Improving anti-hyperglycemic and anti-hypertensive properties of camu-camu (Myriciaria dubia Mc. Vaugh) using lactic acid bacterial fermentation. Process Biochemistry, 59 (Part B), 133–140. https://doi.org/10.1016/j.procbio.2017.05.017García, J. M., Giuffrida, D., Dugo, P., Mondello, L., & Osorio, C. (2018). Development and characterisation of carotenoid-rich microencapsulates from tropical fruit by-products and yellow tamarillo (Solanum betaceum Cav.). Powder Technology, 339, 702–709. https://doi.org/10.1016/J.POWTEC.2018.08.061Garvin, M. R., Alvarez, C., Miller, J. I., Prates, E. T., Walker, A. M., Amos, B. K., Mast, A. E., Justice, A., Aronow, B., & Jacobson, D. (2020). A mechanistic model and therapeutic interventions for Covid-19 involving a RAAS-mediated bradykinin storm. eLife, 9, 1–16. https://doi.org/10.7554/eLife.59177Garzón, G. A., Narváez, C. E., Riedl, K. M., & Schwartz, S. J. (2010). Chemical composition, anthocyanins, non-anthocyanin phenolics and antioxidant activity of wild bilberry (Vaccinium meridionale Swartz) from Colombia. Food Chemistry, 122(4), 980–986. https://doi.org/10.1016/j.foodchem.2010.03.017Gharsallaoui, A., Roudaut, G., Chambin, O., Voilley, A., & Saurel, R. (2007). Applications of spray-drying in microencapsulation of food ingredients: An overview. Food Research International, 40(9), 1107-1121. https://doi.org/10.1016/j.foodres.2007.07.004González, M., Samudio, I., Sequeda-Castañeda, L. G., Celis, C., Iglesias, J., & Morales, L. (2017). Cytotoxic and antioxidant capacity of extracts from Vaccinium meridionale Swartz (Ericaceae) in transformed leukemic cell lines. Journal of Applied Pharmaceutical Science, 7(3), 24–30. https://doi.org/10.7324/JAPS.2017.70305Goñi, I., García-Alonso, A., & Saura-Calixto, F. (1997). A starch hydrolysis procedure to estimate glycemic index. Nutrition Research, 17(3), 427-437. https://doi.org/10.1016/S0271-5317(97)00010-9Grace, M. H., Ribnicky, D. M., Kuhn, P., Poulev, A., Logendra, S., Yousef, G. G., Raskin, I., & Lila, M. A. (2009a). Hypoglycemic activity of a novel anthocyanin-rich formulation from lowbush blueberry, Vaccinium angustifolium Aiton. Phytomedicine, 16(5), 406–415. https://doi.org/10.1016/j.phymed.2009.02.018Haldar, R. N. (2013). Global brief on hypertension: Silent killer, global public health crisis. Indian Journal of Physical Medicine and Rehabilitation, 24(1), 2–2 https://doi.org/10.5005/ijopmr-24-1-2Hämäläinen, M., Nieminen, R., Vuorela, P., Heinonen, M., & Moiianen, E. (2007). Anti-inflammatory effects of flavonoids: Genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappaB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappaB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages. Mediators of Inflammation, 45673. https://doi.org/10.1155/2007/45673Herrera, C., Bolaños, N., & Lutz, G. (2003). Química de Alimentos. Manual de Laboratorio. (pp. 3). San José, Costa Rica: Editorial Universidad de Costa Rica.Hossain, G., Javed, A., Akter, S., & Saha, S. (2021). SARS-CoV-2 host diversity: An update of natural infections and experimental evidence. Journal of Microbiology, Immunology and Infection, 54(2), 175-181. https://doi.org/10.1016/j.jmii.2020.06.006Hou, D-. X., Yanagita, T., Uto, T., Masuzaki, S., & Fujii, M. (2005). Anthocyanidins inhibit cyclooxygenase-2 expression in LPS-evoked macrophages: Structure-activity relationship and molecular mechanisms involved. Biochemical Pharmacology, 70(3), 417–425. https://doi.org/10.1016/j.bcp.2005.05.003Isaza, J. H., Ito, H., & Yoshida, T. (2004). Oligomeric hydrolyzable tannins from Monochaetum multiflorum. Phytochemistry, 65(3), 359–367. https://doi.org/10.1016/j.phytochem.2003.11.017Jenkins, D. J., Wolever, T. M., Taylor, R. H., Barker, H., Fielden, H., Baldwin, J. M., Bowling, A. C., Newman, H. C., Jenkins, A. L., & Goff, D. V. (1981). Glycemic index of foods: a physiological basis for carbohydrate exchange. The American Journal of Clinical Nutrition, 34(3), 362-366. https://academic.oup.com/ajcn/article-abstract/34/3/362/4692881Kamei, H., Kojima, T., Hasegawa, M., Koide, T., Umeda, T., Yukawa, T., & Terabe, K. (1995). Suppression of tumor cell growth by anthocyanins in vitro. Cancer Investigation, 13(6), 590-594.Kim, J. N., Han, S. N., Ha, T. J., & Kim, H-. K. (2017). Black soybean anthocyanins attenuate inflammatory responses by suppressing reactive oxygen species production and mitogen activated protein kinases signaling in lipopolysaccharide-stimulated macrophages. Nutrition Research and Practice, 11(5), 357–364. https://doi.org/10.4162/nrp.2017.11.5.357Kong, J. M., Chia, L. S., Goh, N. K., Chia, T. F., & Brouillard, R. (2003). Analysis and biological activities of anthocyanins. Phytochemistry, 64(5), 923–933. https://doi.org/10.1016/S0031-9422(03)00438-2Lazo-Vélez, M. A., Gutiérrez-Díaz, V. A., Ramírez-Medrano, A., & Serna-Saldívar, S. O. (2013). Effect of sodium selenite addition and sponge dough fermentation on selenomethionine generation during production of yeast-leavened breads. Journal of Cereal Science, 58(1), 164–169. https://doi.org/10.1016/J.JCS.2013.03.019Ligarreto, G. A. (2009). Perspectivas del cultivo de agraz o mortiño (Vaccinium meridionale Swartz) en la zona altoandina de Colombia. 1st Ed. Bogotá: Gente Nueva Editorial.López-Barrios, L., Antunes-Ricardo, M., & Gutiérrez-Uribe, J. A. (2016). Changes in antioxidant and antiinflammatory activity of black bean (Phaseolus vulgaris L.) protein isolates due to germination and enzymatic digestion. Food Chemistry, 203, 417–424. https://doi.org/10.1016/J.FOODCHEM.2016.02.048López-Vidaña, E. C., Pilatowsky Figueroa, I., Cortés, F. B., Rojano, B. A., & Navarro Ocaña, A. (2017). Effect of temperature on antioxidant capacity during drying process of mortiño (Vaccinium meridionale Swartz). International Journal of Food Properties, 20(2), 294–305. https://doi.org/10.1080/10942912.2016.1155601Maldonado Celis, M. E.; Franco Tobón, Y. N.; Agudelo, C.; Arango, S. S. & Rojano, B. (2017) Andean berry (Vaccinium meridionale Swartz). En Fruit and Vegetable Phytochemicals: Chemistry and Human Health, 2nd ed.; Yahia, E. M. Ed.; Wiley-Blackwell, Volume II, pp 869-882.Marín-Echeverri, C., Blesso, C. N., Fernández, M. L., Galvis-Pérez, Y., Ciro-Gómez, G., Núñez-Rangel, V., Aristizábal, J. C., & Barona-Acevedo, J. (2018). Effect of agraz (Vaccinium meridionale Swartz) on high-density lipoprotein function and inflammation in women with metabolic syndrome. Antioxidants, 7(12), 185. https://doi.org/10.3390/antiox7120185Marín-Sánchez, A. (2020). Características clínicas básicas en los primeros 100 casos fatales de COVID-19 en Colombia. Revista Panamericana de Salud Pública, 44(1), 1-4. https://doi.org/10.26633/RPSP.2020.87Mata-Ramírez, D., Serna-Saldívar, S. O., Villela-Castrejón, J., Villaseñor-Durán, M. C., & Buitimea-Cantúa, N. E. (2018). Phytochemical profiles, dietary fiber and baking performance of wheat bread formulations supplemented with Roselle (Hibiscus sabdariffa). Journal of Food Measurement and Characterization, 12(4), 2657–2665. https://doi.org/10.1007/s11694-018-9883-4Mckeown, N. M., Meigs, J. B., Liu, S., Saltzman, E., Wilson, P. W. F., & Jacques, P. F. (2004). Carbohydrate nutrition, insulin resistance, and the prevalence of the metabolic syndrome in the Framingham offspring cohort. Diabetes Care, 27(2), 538-546. https://doi.org/10.2337/diacare.27.2.538Meléndez-Martínez, A. J., Vicario, I. M., & Heredia, F. J. (2003). Application of tristimulus colorimetrý to estimate the carotenoids content in ultrafrozen orange juices. Journal of Agricultural and Food Chemistry, 51 (25), 7266-7270. https://doi.org/10.1021/jf034873zMiguel, M. G. (2011). Anthocyanins: Antioxidant and/or anti-inflammatory activities. Journal of Applied Pharmaceutical Sciences, 1(6), 7-15.Milán-Noris, A. K., de la Rosa-Millán, J., Reyes-Moreno, C., Serna-Saldivar, S. O. (2017) Physicochemical, functional properties, and digestion of isolated starches from pigmented chickpea (Cicer arietinum L.) cultivars. Starch-Stärke, 69, 1600152, https://doi.org/10.1002/star.201600152Mills, K. T., Bundy, J. D., Kelly, T. N., Reed, J. E., Kearney, P. M., Reynolds, K., Chen, J., & He, J. (2016). Global disparities of hypertension prevalence and control. Circulation, 134(6), 441–450. https://doi.org/10.1161/CIRCULATIONAHA.115.018912Mora, A. C. (2016). Comunicación personal de la Secretaría de Fomento Agropecuario de Boyacá.Miyazaki, M., Maeda, T., & Morita, N. (2004) Effect of various dextrin substitutions for wheat flour on dough properties and bread qualities. Food Research International, 37(1), 59-65. https://doi.org/10.1016/j.foodres.2003.08.007Muniyappa, R., & Gubbi, S. (2020). COVID-19 pandemic, coronaviruses, and diabetes mellitus. American Journal of Physiology-Endocrinology and Metabolism, 318(5), E736-E741. https://doi.org/10.1152/ajpendo.00124.2020Onder, G., Rezza, G., & Brusaferro, S. (2020). Case-fatality rate and characteristics of patients dying in Relation to COVID-19 in Italy. JAMA - Journal of the American Medical Association, 323 (18), 1775–1776. https://doi.org/10.1001/jama.2020.4683Onslow, M. W. (2014). The Anthocyanin Pigments of Plants. Cambridge, University Press. https://doi.org/10.5962/bhl.title.1687Onyango, C. (2016). Starch and modified starch in bread making: A review. African Journal of Food Science, 10(12), 344–351. https://doi.org/10.5897/ajfs2016.1481Osorio, C., Forero, D.P., Carrizo, J. G. (2011). Characterisation and performance assessment of guava (Psidium guajava L.) microencapsulates obtained by spray-drying. Food Research International, 44(5), 1174-1181. https://doi.org/10.1016/j.foodres.2010.09.007Parichatikanond, W., Pinthong, D., & Mangmool, S. (2012). Blockade of the renin-angiotensin system with delphinidin, cyanin, and quercetin. Planta Medica, 78(15), 1626–1632. https://doi.org/10.1055/s-0032-1315198Ramírez-Sagredo, A., Ramírez-Reyes, A., Ocaranza, M. P., Chiong, M., Riquelme, J. A., Jalil, J. E., & Lavandero, S. (2020). Antihipertensivos en pacientes con COVID-19. Revista Chilena de Cardiología, 39(1), 66–74. https://doi.org/10.4067/s0718-85602020000100066Revelo, D. (2014). Microencapsulación de tomate de árbol rojo (Solanum betaceum Cav.), mediante spray-drying para aplicación en productos lácteos. Tesis de Maestría en Ciencia y Tecnología de Alimentos. [Universidad Nacional de Colombia - Sede Bogotá]. https://repositorio.unal.edu.co/handle/unal/51865Riaz, M., Zia-Ul-Haq, M., & Saad, B. (2016). The role of anthocyanins in obesity and diabetes. En: Anthocyanins and Human Health: Biomolecular and Therapeutic Aspects. Springer; pags. 109-123.Rincón Soledad, M. C., Buitrago Guacaneme, M. C., Ligarreto Moreno, G. A., Torres Aponte, W. S., & Balaguera López H. E. (2012). Behavior of agraz fruit (Vaccinium meridionale Swartz) harvested in different maturity stages and stored under refrigeration. Revista de la Facultad Nacional de Agronomía de Medellín, 65(2), 6615-6625 https://repositorio.unal.edu.co/handle/unal/71822Rodríguez C, A, Chamorro, F. J., Henao, M., Ospina, R., Nates, G., & Calderón, L. V. (2018). Polinización por abejas en cultivos promisorios de Colombia: agraz (Vaccidium meridionale), chamba (Campomanesia lineatifolia) y cholupa (Passiflora maliformis). Bogotá, Colombia. Universidad Nacional de Colombia. 146 p.Rossi, A., Serraino, I., Dugo, P., di Paola, R., Mondello, L., Genovese, T., Morabito, D., Dugo, G., Sautebin, L., Caputi, A. P., & Cuzzocrea, S. (2003). Protective effects of anthocyanins from blackberry in a rat model of acute lung inflammation. Free Radical Research 37(8), 891–900. https://doi.org/10.1080/1071576031000112690Salmer, J., Manson, J. E., Stampfer, M. J., Colditz, G. A., Wing, A. L., & Willett, W. C. (1997). Dietary fiber, glycemic load, and risk of NIDDM in men. http://jama.jamanetwork.com/Sánchez-Gloria, J. L., Osorio-Alonso, H., Arellano-Buendía, A. S., Carbó, R., Hernández-Díazcouder, A., Guzmán-Martín, C. A., Rubio-Gayosso, I., & Sánchez-Muñoz, F. (2020). Nutraceuticals in the treatment of pulmonary arterial hypertension. International Journal of Molecular Sciences, 21(14), 1–35. https://doi.org/10.3390/ijms21144827Sandhu, K. S., Lim, S.-T.(2008), Digestibility of legume starches as influenced by their physical and structural properties. Carbohydrate polymers 2008, 71, 245-252.Seeram, N. P., Momin, R. A., Nair, M. G., & Bourquin, L. D. (2001). Cyclooxygenase inhibitory and antioxidant cyanidin glycosides in cherries and berries. Phytomedicine, 8(5), 362–369. https://doi.org/10.1078/0944-7113-00053Sharma, J. N., Al-Omran, A., & Parvathy, S. S. (2007). Role of nitric oxide in inflammatory diseases. Inflammopharmacology, 15 (6), 252–259. https://doi.org/10.1007/s10787-007-0013-xShih, P. H., Yeh, Ch.-T., & Yen, G-C. (2005). Effects of anthocyanidin on the inhibition of proliferation and induction of apoptosis in human gastric adenocarcinoma cells. Food and Chemical Toxicology, 43(10), 1557–1566. https://doi.org/10.1016/j.fct.2005.05.001Sigma-Aldrich Co. (2023). Technical Bulletin -Glucosidase Activity Assay Kit. Catalog number MAK123. Disponible on line en: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/286/096/mak123bul.pdfSingleton, V. L., Rossi, J. A. (1965). Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. American Journal of Enology and Viticulture, 16 (3), 144-158. https://www.ajevonline.org/content/16/3/144Siró, I., Kápolna, E., Kápolna, B., & Lugasi, A. (2008). Functional food. Product development, marketing and consumer acceptance-A review. Appetite, 51(3), 456–467. https://doi.org/10.1016/j.appet.2008.05.060Steffen, Y., Gruber, C., Schewe, T., & Sies, H. (2008). Mono-O-methylated flavanols and other flavonoids as inhibitors of endothelial NADPH oxidase. Archives of Biochemistry and Biophysics, 469(2), 209–219. https://doi.org/10.1016/j.abb.2007.10.012Stintzing, F., & Carle, R. (2004). Functional properties of anthocyanins and betalains in plants, food, and in human nutrition. Trends In Food Science & Technology, 15(1), 19-38. https://doi.org/10.1016/j.tifs.2003.07.004Sultan, M. T., Butt, M. S., Karim, R., Iqbal, S. Z., Ahmad, S., Zia-Ul-Haq, M., Aliberti, L., Ahmad, A. N., & De Feo, V. (2014a). Effect of Nigella sativa fixed and essential oils on antioxidant status, hepatic enzymes, and immunity in streptozotocin induced diabetes mellitus. BMC Complementary and Alternative Medicine, 14: 193. https://doi.org/10.1186/1472-6882-14-193Sultan, M. T., Butt, M. S., Karim, R., Zia-Ul-Haq, M., Batool, R., Ahmad, S., Aliberti, L., & de Feo, V. (2014b). Nigella sativa fixed and essential oil supplementation modulates hyperglycemia and allied complications in streptozotocin-induced Diabetes Mellitus. Evidence-Based Complementary and Alternative Medicine, 2014. https://doi.org/10.1155/2014/826380Takikawa, M., Inoue, S., Horio, F., & Tsuda, T. (2010). Dietary anthocyanin-rich bilberry extract ameliorates hyperglycemia and insulin sensitivity via activation of amp-activated protein kinase in diabetic mice. The Journal of Nutrition, 140(3), 527–533. https://doi.org/10.3945/jn.109.118216Toufektsian, M. -C., de Lorgeril, M., Nagy, N., Salen, P., Donati, M. B., Giordano, L., Mock, H. -P., Peterek, S., Matros, A., Petroni, K., Pilu, R., Rotilio, D., Tonelli, C., de Leiris, J., Boucher, F., & Martin, C. (2008). Chronic dietary intake of plant-derived anthocyanins protects the rat heart against ischemia-reperfusion injury. Journal of Nutrition, 138(4), 747–752. https://doi.org/10.1093/jn/138.4.747Vasco, C., Rihinen, K., Ruales, J., & Kamal-Eldin, A. (2009). Chemical composition and phenolic compound profile of Mortiño (Vaccinium floribundum Kunth). Journal of Agricultural and Food Chemistry, 57, (18), 8274-8281. https://doi.org/10.1021/jf9013586Vallejo, D. A. (2000). Fomento al mortiño (Vaccinium meridionale) como especie promisoria del Parque Regional Arví. Corantioquia, MedellínValls, J., Millán, S., Martí, M. P., Borrás, E., & Arola, L. (2009). Advanced separation methods of food anthocyanins, isoflavones and flavanols. Journal of Chromatography A, 1216, 7143–7172. https://doi.org/10.1016/j.chroma.2009.07.030Vendrame, S. & Klimis-Zacas, D. (2019). Potential factors influencing the effects of anthocyanins on blood pressure regulation in humans: A review. Nutrients, 11(6). https://doi.org/10.3390/nu11061431Villacrez, J. L., Carriazo, J. G., & Osorio, C. (2014). Microencapsulation of Andes berry (Rubus glaucus Benth.) aqueous extract by spray drying. Food and Bioprocess Technology, 7(5), 1445–1456. https://doi.org/10.1007/s11947-013-1172-yVillasante, J., Espinosa-Ramírez, J., Pérez-Carrillo, E., Heredia-Olea, E., Metón, I., Almajano, M. P. (2022). Evaluation of non-extruded and extruded pecan (Carya illinoinensis) shell powder as functional ingredient in bread and wheat tortilla. LWT, 160, 113299. https://doi.org/10.1016/j.lwt.2022.113299Wang, H., Nair, M. G., Strasburg, G. M., Chang, Y-. Ch., Booren, A. M., Gray, J. I., & DeWitt, D. L. (1999). Antioxidant and antiinflammatory activities of anthocyanins and their aglycon, cyanidin, from tart cherries. Journal of Natural Products, 62(2), 294–296. https://doi.org/10.1021/np980501m.Wang, Q., Tang, X. N., & Yenari, M. A. (2007). The inflammatory response in stroke. Journal of Neuroimmunology, 184 (1-2), 53-68. https://doi.org/10.1016/j.jneuroim.2006.11.014Wang, X., Jiang, Y., Wang, Y-. W., Huang, M-. T., Ho, C. T., & Huang, Q. (2008). Enhancing anti-inflammation activity of curcumin through O/W nanoemulsions. Food Chemistry, 108(2), 419–424. https://doi.org/10.1016/j.foodchem.2007.10.086Whelton, P. K., Carey, R. M., & Aronow, W. S. (2021). ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: A report of the American College of Cardiology/American Heart Association. Task Force on Clinical Practice. KIDNEYS, 7(1), 68–74. https://doi.org/10.22141/2307-1257.7.1.2018.122220Witczak, M., Korus, J., Ziobro, R., & Juszczak, L. (2010). The effects of maltodextrins on gluten-free dough and quality of bread. Journal of Food Engineering, 96(2), 258-265. https://doi.org/10.1016/j.jfoodeng.2009.07.022Yang, J., Zheng, Y., Gou, X., Pu, K., Chen, Z., Guo, Q., Ji, R., Wang, H., Wang, Y., & Zhou, Y. (2020a). Journal Pre-proof Prevalence of comorbidities in the novel Wuhan coronavirus (COVID-19) infection: a systematic review and meta-analysis. International Journal of Infectious Diseases, 94, 91-95. https://doi.org/10.1016/j.ijid.2020.03.017Yang, X., Yu, Y., Xu, J., Shu, H., Xia, J., Liu, H., Wu, Y., Zhang, L., Yu, Z., Fang, M., Yu, T., Wang, Y., Pan, S., Zou, X., Yuan, S., & Shang, Y. (2020b). Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. The Lancet Respiratory Medicine, 8(5), 475–481. https://doi.org/10.1016/S2213-2600(20)30079-5Yang, M., I. Koo, S., O. Song, W., & K. Chun, O. (2011). Food matrix affecting anthocyanin bioavailability: Review. Current Medicinal Chemistry, 18(2), 291–300. https://doi.org/10.2174/092986711794088380Zapata, I. C., Álzate, A. F., Zapata, K., Arias, J. P., Puertas, M. A., & Rojano, B. (2019). Effect of pH, temperature and time of extraction on the antioxidant properties of Vaccinium meridionale Swartz. Journal of Berry Research, 9(1), 39–49. https://doi.org/10.3233/JBR-18299EstudiantesInvestigadoresMaestrosPúblico generalLICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/84585/1/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD51ORIGINAL1031157610_2023.pdf1031157610_2023.pdfTesis de Maestría en Ciencia y Tecnología de Alimentosapplication/pdf2138418https://repositorio.unal.edu.co/bitstream/unal/84585/2/1031157610_2023.pdff041cc873d8e5ebb067a94626ee82d7bMD52THUMBNAIL1031157610_2023.pdf.jpg1031157610_2023.pdf.jpgGenerated Thumbnailimage/jpeg5500https://repositorio.unal.edu.co/bitstream/unal/84585/3/1031157610_2023.pdf.jpg1dc30fae3b19b1500f30d7335efc38c9MD53unal/84585oai:repositorio.unal.edu.co:unal/845852023-08-22 23:03:39.387Repositorio Institucional Universidad Nacional de Colombiarepositorio_nal@unal.edu.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

Desarrollo de aditivos alimenticios con base en las propiedades biofuncionales del Agraz (Vaccinium meridionale Swartz)

Publicaciones similares