Síntesis, caracterización y evaluación de la actividad anticancerígena de nuevas series de 4-sustituidas 6, 11-dihidro-5h-benzo[b]pirimido[5,4-f]azepinas
Los sistemas heterocíclicos nitrogenados de la dibenzo[b,f]azepina, la pirimidina y del benzimidazol han demostrado tener un amplio espectro de actividad biológica, lo que los ha convertido en blanco de interés en la construccion de nuevos fármacos. Por esta razón, en el Laboratorio de Síntesis Orgá...
- Autores:
-
Burgos Ortiz, Isidro
- Tipo de recurso:
- http://purl.org/coar/version/c_b1a7d7d4d402bcce
- Fecha de publicación:
- 2016
- Institución:
- Universidad Industrial de Santander
- Repositorio:
- Repositorio UIS
- Idioma:
- spa
- OAI Identifier:
- oai:noesis.uis.edu.co:20.500.14071/34959
- Palabra clave:
- Dibenzo[B
F]Azepinas
Pirimidina
Benzimidazol
Sustitución Nucleofílica Aromática
Ciclocondesación Oxidativa
Ciclación Intramolecular De Friedelcrafts.
Nitrogen based heterocyclic systems from the dibenz[b
f]azepines
pyrimidine and the benzimidazole have proven to have a wide spectrum of biologic activity
which has placed them hesis route was designed based on three classic reactions: nucleophilic Moreover
by the funtionalization of the 5
6dihydro11Hbenzo[b]pyrimido[5
4f]azepines previously synthesized in the LSO and the aminolysis and butanolysis reactions
the diversification of these systems was accomplished. In the present degree project the structural analogues were synthesized from the 5allyl4
6dichloropyrimidine
which was the suitable precursor to build these systems
with the purpose of creating new molecules and to enrich the chemical library previously reported. Finally
the anticancer activity potencial from the new 4substituted 6
11dihydro11Hbenz[b]pyrimido[5
4f]azepines was tested on preliminary essays over a complete panel of approximately 60 human cancer cell lines
elaborated at the National Cancer Institute (NCI) in the United States; the results demonstrated an outstanding anticancer activity from the in vitro essays because this kind of compounds are structural hybrids that are constituted over the widely studied pharmacophoric components.
- Rights
- License
- Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)