Caracterización espectroscópica de compuestos de interés biológico: quinolinas y derivados, evaluación de su posible aplicación antimaterial
Entre los alcaloides, una de las familias más estudiadas son los compuestos quinolinicos debido a su amplio rango de actividades biológicas. Los diferentes compuestos, desde el punto de vista de caracterización espectroscópica no han sido completamente caracterizados. En este trabajo se presentan lo...
- Autores:
-
Baron Leon, Martha Milena
Comas Toscano, Sindy Marcela
- Tipo de recurso:
- http://purl.org/coar/version/c_b1a7d7d4d402bcce
- Fecha de publicación:
- 2016
- Institución:
- Universidad Industrial de Santander
- Repositorio:
- Repositorio UIS
- Idioma:
- spa
- OAI Identifier:
- oai:noesis.uis.edu.co:20.500.14071/34392
- Palabra clave:
- Tetrahidroquinolínas
Ftir
Fluorescencia
Uv-Vis
Raman
Pseudomona Aeruginosa
Escherichia Coli
Sthapylococcus Aerus Resistente A La Meticilina (Sarm).
Among the alkaloids
one of the most studied families are the quinoline compounds because of its biological activities wide range. Different compounds from the spectroscopic characterization viewpoint have not been fully characterized. In this paper are presented the characterization result through various spectroscopic techniques (fluorescence
FTIR
Raman and UV-visible) to determinate interesting parameters as the molar extinction coefficient; essential for studying fluorescence
structural factors (changes in functional groups) and evaluation of their possible antibacterial application. By signals characteristics or fingerprints are identified the links; C-Cl
NO2
amine and amide in the spectroscopic responses that confirm testing compounds; through these techniques are evidenced advantages such as sensitivity
preparation speed and data collection. In bioassay (antibacterial)
the effect of the bacterial derivatives growth against bacteria Pseudomonas aeruginosa
Escherichia coli
Sthapylococcus Aerus Methicillin Resistant (SAMR)
was studied by microdilution broth method in which inhibition is measured in the growth of each bacterial strain in the presence of each of quinolines in a concentration range of 1-100 µM comparing them with the positive and negative control in each case
which presented minimum inhibitory concentration above 50% especially for SAMR in the presence of tetrahydroquinolines
this concentration is within the range of therapeutic concentrations currently employed for the treatment of infections
- Rights
- License
- Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)