Biochemical characterization of the bifunctional enzyme dihydrofolate reductase-thymidylate synthase from Leishmania (Viannia) and its evaluation as a drug target

ABSTRACT : Introduction. Dihydrofolate reductase (DHFR) has been used successfully as a drug target in the area of anti-bacterial, anti-cancer and anti-malarial therapy. Although this bifunctional enzyme is also a potential drug target for treatment of leishmaniasis, there have been no reports on it...

Full description

Autores:

Osorio Durango, Edison
Aguilera Gálvez, Carolina
Naranjo Díaz, Nelson Jezzid
Marín Villa, Marcel
Muskus López, Carlos Enrique

Tipo de recurso:

Article of investigation

Fecha de publicación:

2013

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/29319

Acceso en línea:

http://hdl.handle.net/10495/29319

Palabra clave:

Leishmania braziliensis
Tetrahidrofolato Deshidrogenasa
Tetrahydrofolate Dehydrogenase
Timidilato Sintasa
Thymidylate Synthase
Antagonistas del Ácido Fólico
Folic Acid Antagonists

Rights

openAccess

License

http://creativecommons.org/licenses/by-nc-nd/2.5/co/