Assessment of a modified release verapamil.HCl matrix compacts : Effect of formulation composition on the in-vitro release kinetic
ABSTRACT: Verapamil hydrochloride is a drug used to treat arrhythmias. In this study, a D-optimal mixture design with 16 runs was used to select the best combination of three polymers into a matrix that rendered an 8 h in vitro release profile of verapamil. hydrochloride (HCl) which fulfill a once-a...
- Autores:
-
Rojas Camargo, John
Aristizábal, Julián
Sánchez, Joan
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2013
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/25207
- Acceso en línea:
- http://hdl.handle.net/10495/25207
- Palabra clave:
- Verapamilo
Verapamil
Dinámicas no Lineales
Nonlinear Dynamics
Diseño experimental
Experimental design
Controlled-release preparations
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by/2.5/co/
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| dc.title.spa.fl_str_mv |
Assessment of a modified release verapamil.HCl matrix compacts : Effect of formulation composition on the in-vitro release kinetic |
| title |
Assessment of a modified release verapamil.HCl matrix compacts : Effect of formulation composition on the in-vitro release kinetic |
| spellingShingle |
Assessment of a modified release verapamil.HCl matrix compacts : Effect of formulation composition on the in-vitro release kinetic Verapamilo Verapamil Dinámicas no Lineales Nonlinear Dynamics Diseño experimental Experimental design Controlled-release preparations |
| title_short |
Assessment of a modified release verapamil.HCl matrix compacts : Effect of formulation composition on the in-vitro release kinetic |
| title_full |
Assessment of a modified release verapamil.HCl matrix compacts : Effect of formulation composition on the in-vitro release kinetic |
| title_fullStr |
Assessment of a modified release verapamil.HCl matrix compacts : Effect of formulation composition on the in-vitro release kinetic |
| title_full_unstemmed |
Assessment of a modified release verapamil.HCl matrix compacts : Effect of formulation composition on the in-vitro release kinetic |
| title_sort |
Assessment of a modified release verapamil.HCl matrix compacts : Effect of formulation composition on the in-vitro release kinetic |
| dc.creator.fl_str_mv |
Rojas Camargo, John Aristizábal, Julián Sánchez, Joan |
| dc.contributor.author.none.fl_str_mv |
Rojas Camargo, John Aristizábal, Julián Sánchez, Joan |
| dc.subject.decs.none.fl_str_mv |
Verapamilo Verapamil Dinámicas no Lineales Nonlinear Dynamics |
| topic |
Verapamilo Verapamil Dinámicas no Lineales Nonlinear Dynamics Diseño experimental Experimental design Controlled-release preparations |
| dc.subject.lemb.none.fl_str_mv |
Diseño experimental Experimental design |
| dc.subject.proposal.spa.fl_str_mv |
Controlled-release preparations |
| description |
ABSTRACT: Verapamil hydrochloride is a drug used to treat arrhythmias. In this study, a D-optimal mixture design with 16 runs was used to select the best combination of three polymers into a matrix that rendered an 8 h in vitro release profile of verapamil. hydrochloride (HCl) which fulfill a once-a-day modified release in compliance with the United States Pharmacopeia (USP) specifications. The Korsmeyer-Peppas model was used to fit the dissolution data since it presented the best fitting characteristics. A cubic model predicted the best formulation of verapamil.HCl containing carnauba wax, hydroxypropyl methyl cellulose and Avicel_PH101 at the 40, 20 and 40% levels, respectively. Validation runs confirmed the accuracy of the cubic models which include these three components. |
| publishDate |
2013 |
| dc.date.issued.none.fl_str_mv |
2013 |
| dc.date.accessioned.none.fl_str_mv |
2022-01-08T16:28:25Z |
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2022-01-08T16:28:25Z |
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info:eu-repo/semantics/article |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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https://purl.org/redcol/resource_type/ART |
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Artículo de investigación |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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publishedVersion |
| dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10495/25207 |
| dc.identifier.doi.none.fl_str_mv |
10.5897/AJPP2013.3466 |
| dc.identifier.eissn.none.fl_str_mv |
1996-0816 |
| url |
http://hdl.handle.net/10495/25207 |
| identifier_str_mv |
10.5897/AJPP2013.3466 1996-0816 |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartofjournalabbrev.spa.fl_str_mv |
Afr. J. Pharm. Pharmacol. |
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info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by/2.5/co/ |
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https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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http://creativecommons.org/licenses/by/2.5/co/ http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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7 |
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application/pdf |
| dc.publisher.spa.fl_str_mv |
Academic Journals |
| dc.publisher.group.spa.fl_str_mv |
Diseño y Formulación de Medicamentos Cosméticos y Afines |
| dc.publisher.place.spa.fl_str_mv |
Lagos, Nigeria |
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Universidad de Antioquia |
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Rojas Camargo, JohnAristizábal, JuliánSánchez, Joan2022-01-08T16:28:25Z2022-01-08T16:28:25Z2013http://hdl.handle.net/10495/2520710.5897/AJPP2013.34661996-0816ABSTRACT: Verapamil hydrochloride is a drug used to treat arrhythmias. In this study, a D-optimal mixture design with 16 runs was used to select the best combination of three polymers into a matrix that rendered an 8 h in vitro release profile of verapamil. hydrochloride (HCl) which fulfill a once-a-day modified release in compliance with the United States Pharmacopeia (USP) specifications. The Korsmeyer-Peppas model was used to fit the dissolution data since it presented the best fitting characteristics. A cubic model predicted the best formulation of verapamil.HCl containing carnauba wax, hydroxypropyl methyl cellulose and Avicel_PH101 at the 40, 20 and 40% levels, respectively. Validation runs confirmed the accuracy of the cubic models which include these three components.COL00036237application/pdfengAcademic JournalsDiseño y Formulación de Medicamentos Cosméticos y AfinesLagos, Nigeriainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTArtículo de investigaciónhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/2.5/co/http://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by/4.0/Assessment of a modified release verapamil.HCl matrix compacts : Effect of formulation composition on the in-vitro release kineticVerapamiloVerapamilDinámicas no LinealesNonlinear DynamicsDiseño experimentalExperimental designControlled-release preparationsAfr. J. Pharm. Pharmacol.African Journal of Pharmacy and Pharmacology793800715CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8927http://bibliotecadigital.udea.edu.co/bitstream/10495/25207/2/license_rdf1646d1f6b96dbbbc38035efc9239ac9cMD52ORIGINALRojasJohn_2013_AssessmentModifiedVerapamil.pdfRojasJohn_2013_AssessmentModifiedVerapamil.pdfArtículo de investigaciónapplication/pdf534135http://bibliotecadigital.udea.edu.co/bitstream/10495/25207/1/RojasJohn_2013_AssessmentModifiedVerapamil.pdf7a15bd422d13fd35d069680d666328e2MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://bibliotecadigital.udea.edu.co/bitstream/10495/25207/3/license.txt8a4605be74aa9ea9d79846c1fba20a33MD5310495/25207oai:bibliotecadigital.udea.edu.co:10495/252072022-01-08 11:28:26.01Repositorio Institucional Universidad de Antioquiaandres.perez@udea.edu.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 |