Functional assessment of four types of disintegrants and their effect on the spironolactone release properties
ABSTRACT: Spironolactone is a drug derived from sterols that exhibits an incomplete oral absorption due to its low water solubility and slow dissolution rate. In this study, formulations of spironolactone with four disintegrants named as croscarmellose sodium, crospovidone, sodium starch glycolate a...
- Autores:
-
Rojas Camargo, John
Guisao Paniagua, Santiago
Ruge, Vanesa
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2012
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/20350
- Acceso en línea:
- http://hdl.handle.net/10495/20350
- Palabra clave:
- Espironolactona
Spironolactone
Disolución
Dissolution
Factorial experimental design
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by-nc-sa/2.5/co/