Functional assessment of four types of disintegrants and their effect on the spironolactone release properties

ABSTRACT: Spironolactone is a drug derived from sterols that exhibits an incomplete oral absorption due to its low water solubility and slow dissolution rate. In this study, formulations of spironolactone with four disintegrants named as croscarmellose sodium, crospovidone, sodium starch glycolate a...

Full description

Autores:
Rojas Camargo, John
Guisao Paniagua, Santiago
Ruge, Vanesa
Tipo de recurso:
Article of investigation
Fecha de publicación:
2012
Institución:
Universidad de Antioquia
Repositorio:
Repositorio UdeA
Idioma:
eng
OAI Identifier:
oai:bibliotecadigital.udea.edu.co:10495/20350
Acceso en línea:
http://hdl.handle.net/10495/20350
Palabra clave:
Espironolactona
Spironolactone
Disolución
Dissolution
Factorial experimental design
Rights
openAccess
License
http://creativecommons.org/licenses/by-nc-sa/2.5/co/