Identification of (4-(9H-fluoren-9-yl) piperazin-1-yl) methanone derivatives as falcipain 2 inhibitors active against Plasmodium falciparum cultures

ABSTRACT: Background: Falcipain 2 (FP-2) is the hemoglobin-degrading cysteine protease of Plasmodium falciparum most extensively targeted to develop novel antimalarials. However, no commercial antimalarial drugs based on FP-2 inhibition are available yet due to the low selectivity of most FP-2 inhib...

Full description

Autores:

Hernández González, Jorge Enrique
Salas Sarduy, Emir
Hernández Ramírez, Luisa Fernanda
Pascual, María José
Álvarez, Diego
Pabón Vidal, Adriana
Leitea, Vitor Barbanti
Pascuttie, Pedro
Valiente, Pedro

Tipo de recurso:

Article of investigation

Fecha de publicación:

2018

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/26424

Acceso en línea:

http://hdl.handle.net/10495/26424

Palabra clave:

Plasmodium falciparum
Simulación de Dinámica Molecular
Molecular Dynamics Simulation
Antimaláricos
Antimalarials
Cisteína Endopeptidasas
Cysteine Endopeptidases
Concentración 50 Inhibidora
Inhibitory Concentration 50
Relación Estructura-Actividad
Structure-Activity Relationship

Rights

openAccess

License

http://purl.org/coar/access_right/c_abf2