Synthesis and cytotoxic activity of per-acetylated and halogenated derivatives of nucleosides in breast cancer cells

ABSTRACT: Objectives. To make the synthesis of halogenated derivatives on the nitrogenous base and their respective acyl ester and amide type derivatives for all hydroxyl and amine groups of the uridine and cytarabine nucleosides, and evaluate cytotoxicity against breast cancer cell line. Methods. F...

Full description

Autores:

Berrío Escobar, Jhon Fernando
Pastrana Restrepo, Manuel Humberto
Galeano Jaramillo, Elkin de Jesús
Márquez Fernández, Diana Margarita
Márquez Fernández, María Elena
Martínez Martínez, Alejandro

Tipo de recurso:

Article of investigation

Fecha de publicación:

2017

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/24051

Acceso en línea:

http://hdl.handle.net/10495/24051
http://revistaseug.ugr.es/index.php/ars/article/view/6441

Palabra clave:

Neoplasias de la Mama
Breast Neoplasms
Nucleósidos
Nucleosides
Uridina
Uridine
Citarabina
Cytarabine
Citotoxicidad
Cytotoxicity
http://aims.fao.org/aos/agrovoc/c_34251

Rights

openAccess

License

http://creativecommons.org/licenses/by-nc-sa/2.5/co/