Preparation of Rotenone Derivatives and in Vitro Analysis of Their Antimalarial, Antileishmanial and Selective Cytotoxic Activities

ABSTRACT: Six derivatives of the known biopesticide rotenone were prepared by several chemical transformations. Rotenone and its derivatives showed differential in vitro antiparasitic activity and selective cytotoxicity. In general, compounds were more active against Plasmodium falciparum than Leish...

Full description

Autores:

Upegui Zapata, Yulieth Alexandra
Gil Romero, Juan Fernando
Quiñones Fletcher, Winston
Torres, Fernando
Escobar Peláez, Gustavo
Robledo Restrepo, Sara María
Echeverri López, Luis Fernando

Tipo de recurso:

Article of investigation

Fecha de publicación:

2014

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/23682

Acceso en línea:

http://hdl.handle.net/10495/23682

Palabra clave:

Rotenone
Rotenona
Cytotoxicity
Cytotoxicidad
Chemical transformations
Antiparasite
Differential activity
http://aims.fao.org/aos/agrovoc/c_6665
http://aims.fao.org/aos/agrovoc/c_34251

Rights

openAccess

License

http://creativecommons.org/licenses/by/2.5/co/