Formulation of a modified release metformin.HCl matrix tablets : influence of some hydrophilic polymers on the release rate and in-vitro evaluation

ABSTRACT: Metformin hydrochloride is an antidiabetic agent which improves glucose tolerance in patients with type 2 diabetes and reduces basal plasma levels of glucose. In this study, a simplex centroid experimental design with 69 runs was used to select the best combination of some hydrophilic poly...