Quantitative defects in invariant NKT cells and TLR responses in patients with hyper-IgE syndrome

ABSTRACT: Background Autosomal dominant hyper-IgE syndrome (AD-HIES) is a primary immunodeficiency mainly caused by mutations in STAT3, a signalling molecule implicated in the development of appropriate immune responses. We aimed to characterise the innate immune response in AD-HIES. Methods The fre...