Dynamic quantitative description of the metabolic capabilities of Streptomyces clavuligerus for clavulanic acid production

ABSTRACT: Clavulanic acid (CA) is a β-lactam antibiotic with potent inhibitory activity against β-lactamase enzymes, which are responsible for the antibiotic resistance phenomenon in several pathogenic bacteria. CA is a secondary metabolite of pharmaceutical and industrial interest naturally produce...

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Autores:

Gómez Ríos, David Andrés

Tipo de recurso:

Doctoral thesis

Fecha de publicación:

2020

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

spa

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/16422

Acceso en línea:

http://hdl.handle.net/10495/16422

Palabra clave:

Clavulanic acid
Enzymes
Enzima
Scientific information systems
Sistema de información científica
Metabolism
Metabolismo
Pharmaceutical technology
Tecnología farmacéutica
Bacteria
Bacteria
Hydrodynamics
Hidrodinámica
Resistance to antibiotics
Resistencia a los antibióticos
Dynamic flux balance analysis
Fed-batch
Flux balance analysis
Genome-scale model
Single-use bioreactor
Streptomyces clavuligerus
http://aims.fao.org/aos/agrovoc/c_8848
http://id.loc.gov/authorities/subjects/sh85026861
http://vocabularies.unesco.org/thesaurus/concept3945
http://vocabularies.unesco.org/thesaurus/concept3777
http://vocabularies.unesco.org/thesaurus/concept3954
http://vocabularies.unesco.org/thesaurus/concept4099
http://vocabularies.unesco.org/thesaurus/concept1950
http://vocabularies.unesco.org/thesaurus/concept8575

Rights

openAccess

License

Atribución-NoComercial-SinDerivadas 2.5 Colombia (CC BY-NC-ND 2.5 CO)