Prostaglandin F2αsynthase in Trypanosoma cruziplays critical roles in oxidative stress and susceptibility to benznidazole

ABSTRACT: Nifurtimox (Nfx) and benznidazole (Bz) are the current drugs used for the treatment of Chagas disease. The mechanisms of action and resistance to these drugs in this parasite are poorly known. Prostaglandin F2α synthase or old yellow enzyme (OYE), an NAD(P)H flavin oxidoreductase, has been...