The impact of different presenilin 1 and presenilin 2 mutations on amyloid pososition, neurofibrillary changes and neuronal loss in the familial Alzheimer's disease brain. Evidence for other phenotype-modifying factors

ABSTRACT: To assess the influence of the presenilin 1 (PS1) and 2 (PS2) mutations on amyloid deposition, neurofibrillary tangle (NFT) formation and neuronal loss, we performed stereologically based counts in a high-order association cortex, the superior temporal sulcus, of 30 familial Alzheimer'...

Full description

Autores:

Gómez Isla, Teresa
Growdon, Whitfield B.
McNamara, Megan J.
Nochlin, David
Bird, Thomas D.
Arango Viana, Juan Carlos
Lopera Restrepo, Francisco Javier
Kosik, Kenneth S.
Lantos, Peter L.
Cairns, Nigel J.
Hyman, Bradley T.

Tipo de recurso:

Article of investigation

Fecha de publicación:

1999

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/25831

Acceso en línea:

http://hdl.handle.net/10495/25831

Palabra clave:

Enfermedad de Alzheimer
Alzheimer Disease
Presenilina-1
Presenilin-1
Ovillos Neurofibrilares
Neurofibrillary Tangles
Presenilina-2
Presenilin-2
Aβ plaques

Rights

openAccess

License

http://creativecommons.org/licenses/by-nc/2.5/co/