Role of AKT/mTORC1 pathway in pancreatic β-cell proliferation
ABSTRACT: Growth factors, insulin signaling and nutrients are important regulators of β-cell mass and function. The events linking these signals to regulation of β-cell mass are not completely understood. Recent findings indicate that mTOR pathway integrates signals from growth factors and nutrients...
- Autores:
-
Balcázar Morales, Norman
Cecilia, Aguilar de Plata
- Tipo de recurso:
- Review article
- Fecha de publicación:
- 2012
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/22206
- Acceso en línea:
- http://hdl.handle.net/10495/22206
- Palabra clave:
- Islets of Langerhans
Islotes Pancreáticos
Signal Transduction
Transducción de Señal
Cell Proliferation
Proliferación Celular
Cell cycle
Ciclo Celular
Diabetes
Type 2
AKT/PKB/mTORC1
http://aims.fao.org/aos/agrovoc/c_10361
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by-nc-nd/2.5/co/
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| dc.title.spa.fl_str_mv |
Role of AKT/mTORC1 pathway in pancreatic β-cell proliferation |
| dc.title.alternative.spa.fl_str_mv |
Participación de la vía de señalización AKT/mTORC1 en la proliferación de las células β del páncreas |
| title |
Role of AKT/mTORC1 pathway in pancreatic β-cell proliferation |
| spellingShingle |
Role of AKT/mTORC1 pathway in pancreatic β-cell proliferation Islets of Langerhans Islotes Pancreáticos Signal Transduction Transducción de Señal Cell Proliferation Proliferación Celular Cell cycle Ciclo Celular Diabetes Type 2 AKT/PKB/mTORC1 http://aims.fao.org/aos/agrovoc/c_10361 |
| title_short |
Role of AKT/mTORC1 pathway in pancreatic β-cell proliferation |
| title_full |
Role of AKT/mTORC1 pathway in pancreatic β-cell proliferation |
| title_fullStr |
Role of AKT/mTORC1 pathway in pancreatic β-cell proliferation |
| title_full_unstemmed |
Role of AKT/mTORC1 pathway in pancreatic β-cell proliferation |
| title_sort |
Role of AKT/mTORC1 pathway in pancreatic β-cell proliferation |
| dc.creator.fl_str_mv |
Balcázar Morales, Norman Cecilia, Aguilar de Plata |
| dc.contributor.author.none.fl_str_mv |
Balcázar Morales, Norman Cecilia, Aguilar de Plata |
| dc.subject.decs.none.fl_str_mv |
Islets of Langerhans Islotes Pancreáticos Signal Transduction Transducción de Señal Cell Proliferation Proliferación Celular Cell cycle Ciclo Celular |
| topic |
Islets of Langerhans Islotes Pancreáticos Signal Transduction Transducción de Señal Cell Proliferation Proliferación Celular Cell cycle Ciclo Celular Diabetes Type 2 AKT/PKB/mTORC1 http://aims.fao.org/aos/agrovoc/c_10361 |
| dc.subject.agrovoc.none.fl_str_mv |
Diabetes |
| dc.subject.proposal.spa.fl_str_mv |
Type 2 AKT/PKB/mTORC1 |
| dc.subject.agrovocuri.none.fl_str_mv |
http://aims.fao.org/aos/agrovoc/c_10361 |
| description |
ABSTRACT: Growth factors, insulin signaling and nutrients are important regulators of β-cell mass and function. The events linking these signals to regulation of β-cell mass are not completely understood. Recent findings indicate that mTOR pathway integrates signals from growth factors and nutrients with transcription, translation, cell size, cytoskeleton remodeling and mitochondrial metabolism. mTOR is a part of two distinct complexes; mTORC1 and mTORC2. The mammalian TORC1 is sensitive to rapamycin and contains Raptor, deptor, PRAS40 and the G protein β-subunit-like protein (GβL). mTORC1 activates key regulators of protein translation; ribosomal S6 kinase (S6K) and eukaryote initiation factor 4E-binding protein 1. This review summarizes current findings about the role of AKT/mTORC1 signaling in regulation of pancreatic β cell mass and proliferation. mTORC1 is a major regulator of β-cell cycle progression by modulation of cyclins D2, D3 and cdk4/cyclin D activity. These studies uncovered key novel pathways controlling cell cycle progression in β-cells in vivo. This information can be used to develop alternative approaches to expand β-cell mass in vivo and in vitro without the risk of oncogenic transformation. The acquisition of such knowledge is critical for the design of improved therapeutic strategies for the treatment and cure of diabetes as well as to understand the effects of mTOR inhibitors in β-cell function. |
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2012 |
| dc.date.issued.none.fl_str_mv |
2012 |
| dc.date.accessioned.none.fl_str_mv |
2021-09-04T15:38:57Z |
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2021-09-04T15:38:57Z |
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info:eu-repo/semantics/article |
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Balcázar, N. & Aguilar, C. (2012). Papel de la vía AKT / mTORC1 en la proliferación de células β pancreáticas. Colombia Médica , 43 (3), 235-243. https://doi.org/10.25100/cm.v43i3.783 |
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0120-8322 |
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http://hdl.handle.net/10495/22206 |
| dc.identifier.doi.none.fl_str_mv |
10.25100/cm.v43i3.783 |
| dc.identifier.eissn.none.fl_str_mv |
1657-9534 |
| identifier_str_mv |
Balcázar, N. & Aguilar, C. (2012). Papel de la vía AKT / mTORC1 en la proliferación de células β pancreáticas. Colombia Médica , 43 (3), 235-243. https://doi.org/10.25100/cm.v43i3.783 0120-8322 10.25100/cm.v43i3.783 1657-9534 |
| url |
http://hdl.handle.net/10495/22206 |
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eng |
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eng |
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Colomb. med. |
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Universidad del Valle |
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Genética Molecular (GENMOL) |
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Cali, Colombia |
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Universidad de Antioquia |
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Balcázar Morales, NormanCecilia, Aguilar de Plata2021-09-04T15:38:57Z2021-09-04T15:38:57Z2012Balcázar, N. & Aguilar, C. (2012). Papel de la vía AKT / mTORC1 en la proliferación de células β pancreáticas. Colombia Médica , 43 (3), 235-243. https://doi.org/10.25100/cm.v43i3.7830120-8322http://hdl.handle.net/10495/2220610.25100/cm.v43i3.7831657-9534ABSTRACT: Growth factors, insulin signaling and nutrients are important regulators of β-cell mass and function. The events linking these signals to regulation of β-cell mass are not completely understood. Recent findings indicate that mTOR pathway integrates signals from growth factors and nutrients with transcription, translation, cell size, cytoskeleton remodeling and mitochondrial metabolism. mTOR is a part of two distinct complexes; mTORC1 and mTORC2. The mammalian TORC1 is sensitive to rapamycin and contains Raptor, deptor, PRAS40 and the G protein β-subunit-like protein (GβL). mTORC1 activates key regulators of protein translation; ribosomal S6 kinase (S6K) and eukaryote initiation factor 4E-binding protein 1. This review summarizes current findings about the role of AKT/mTORC1 signaling in regulation of pancreatic β cell mass and proliferation. mTORC1 is a major regulator of β-cell cycle progression by modulation of cyclins D2, D3 and cdk4/cyclin D activity. These studies uncovered key novel pathways controlling cell cycle progression in β-cells in vivo. This information can be used to develop alternative approaches to expand β-cell mass in vivo and in vitro without the risk of oncogenic transformation. The acquisition of such knowledge is critical for the design of improved therapeutic strategies for the treatment and cure of diabetes as well as to understand the effects of mTOR inhibitors in β-cell function.RESUMEN: Factores de crecimiento y nutrientes son reguladores muy importantes de la masa y función de las células β, pero las vías de señalización que unen estas señales a estos procesos no han sido completamente elucidadas. Estudios recientes han demostrado que la proteína mTOR integra señales provenientes de factores de crecimiento y disponibilidad de nutrientes con procesos celulares como transcripción, traducción, organización del citoesqueleto y metabolismo mitocondrial. mTOR puede hacer parte de dos complejos diferentes, mTORC1 y mTORC2. En el complejo mTORC1, la proteina mTOR la cual es sensible a rapamicina y se encuentra asociada a las proteínas Raptor, G β L, deptor y PRAS40, activa reguladores claves en la síntesis de proteínas, tales como la proteína cinasa ribosomal S6 (S6K) y la proteína de unión al factor eucariótico de iniciación 4E.El presente trabajo recopila información reciente sobre la participación de la vía de señalización AKT/mTORC1 en la regulación de la proliferación y masa de las células β del páncreas. mTORC1 regula la progresión del ciclo celular en células β, mediante la modulación de los niveles de las ciclinas D2 y D3 y la actividad del complejo Cdk4/ciclina D. Estos estudios que revelan nuevos puntos de control del ciclo celular en células β, pueden ser utilizados en el desarrollo de nuevos enfoques para expandir la masa de células β, sin el riesgo de inducir una transformación oncogénica. Los resultados relacionados en el presente trabajo aportan información muy valiosa para el desarrollo de nuevas estrategias terapéuticas para el tratamiento la diabetes tipo 2.COL00067238application/pdfengUniversidad del ValleGenética Molecular (GENMOL)Cali, Colombiainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bchttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTREVArtículo de revisiónhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/2.5/co/http://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by-nc-nd/4.0/Role of AKT/mTORC1 pathway in pancreatic β-cell proliferationParticipación de la vía de señalización AKT/mTORC1 en la proliferación de las células β del páncreasIslets of LangerhansIslotes PancreáticosSignal TransductionTransducción de SeñalCell ProliferationProliferación CelularCell cycleCiclo CelularDiabetesType 2AKT/PKB/mTORC1http://aims.fao.org/aos/agrovoc/c_10361Colomb. med.Colombia Médica235243433CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8823https://bibliotecadigital.udea.edu.co/bitstream/10495/22206/2/license_rdfb88b088d9957e670ce3b3fbe2eedbc13MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://bibliotecadigital.udea.edu.co/bitstream/10495/22206/3/license.txt8a4605be74aa9ea9d79846c1fba20a33MD53ORIGINALMoralesNorman_2012_PancreaticβCellProliferation.pdfMoralesNorman_2012_PancreaticβCellProliferation.pdfArtículo de revisiónapplication/pdf614417https://bibliotecadigital.udea.edu.co/bitstream/10495/22206/1/MoralesNorman_2012_Pancreatic%ce%b2CellProliferation.pdfb63191ccde4d9b08610b400594b6647dMD5110495/22206oai:bibliotecadigital.udea.edu.co:10495/222062023-04-25 12:24:35.829Repositorio Institucional Universidad de Antioquiaandres.perez@udea.edu.coTk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0Cm93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLAp0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZwp0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sCmluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlCnN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yCnB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZQp0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQKdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uCmFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LAp5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZQpjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdApzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkCndpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRApCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUKRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSApDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZQpzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMKbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo= |