Exploring the scope of new arylamino alcohol derivatives: Synthesis, antimalarial evaluation, toxicological studies, and target exploration

ABSTRACT: Synthesis of new 1-aryl-3-substituted propanol derivatives followed by structure-activity relationship, in silico drug-likeness, cytotoxicity, genotoxicity, in silico metabolism, in silico pharmacophore modeling, and in vivo studies led to the identification of compounds 22 and 23 with sig...

Full description

Autores:

Pabón Vidal, Adriana Lucía
Quiliano, Miguel
Mendoza, Adela
Fong, Kim
Goldfarb, Nathan
Fabing, Isabelle
Vettorazzi, Ariane
López de Cerain, Adela
Dunn, Ben
Garavito, Giovanny
Wright, David
DeHaro, Eric
Pérez Silanes, Silvia
Aldana, Ignacio
Galiano, Silvia

Tipo de recurso:

Article of investigation

Fecha de publicación:

2016

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/32004

Acceso en línea:

https://hdl.handle.net/10495/32004

Palabra clave:

Drug-Related Side Effects and Adverse Reactions
Antimaláricos
Antimalarials
Amino Alcoholes
Amino Alcohols
Modelos Animales de Enfermedad
Disease Models, Animal
Concentración 50 Inhibidora
Inhibitory Concentration 50
Malaria Falciparum
Malaria, Falciparum
Plasmodium falciparum
Relación Estructura-Actividad
Structure-Activity Relationship
Resultado del Tratamiento
Treatment Outcome
Análisis de Supervivencia
Survival Analysis
Ratones
Mice
http://id.nlm.nih.gov/mesh/D064420

Rights

openAccess

License

http://creativecommons.org/licenses/by-nc-nd/2.5/co/