Search of Allosteric Inhibitors and Associated Proteins of an AKT-like Kinase from Trypanosoma cruzi

ABSTRACT: Proteins associated to the PI3K/AKT/mTOR signaling pathway are widely used targets for cancer treatment, and in recent years they have also been evaluated as putative targets in trypanosomatids parasites, such as Trypanosoma cruzi. Here, we performed a virtual screening approach to find ca...

Full description

Autores:
Ochoa de Ossa, Rodrigo Alonso
Rocha Roa, Cristian
Marín Villa, Marcel
Robledo Restrepo, Sara María
Varela Miranda, Rubén Eduardo
Tipo de recurso:
Article of investigation
Fecha de publicación:
2018
Institución:
Universidad de Antioquia
Repositorio:
Repositorio UdeA
Idioma:
eng
OAI Identifier:
oai:bibliotecadigital.udea.edu.co:10495/32013
Acceso en línea:
https://hdl.handle.net/10495/32013
Palabra clave:
Trypanosoma cruzi
Dominios Homólogos a Pleckstrina
Pleckstrin Homology Domains
Descubrimiento de Drogas
Drug Discovery
Proteínas Proto-Oncogénicas c-akt
Proto-Oncogene Proteins c-akt
Rights
openAccess
License
http://creativecommons.org/licenses/by/2.5/co/