Obtaining nettle extracts (Urtica dioica L) by means of hydrocavitation

La ortiga (Urtica dioica L.) se considera una gran fuente de metabolitos secundarios de interés comercial y la extracción de este tipo de metabolitos es importante para la viabilidad y escalado del proceso. Se han evaluado diferentes alternativas, incluida la extracción Soxhlet y el uso de fluidos s...

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Autores:: Aguirre Dúran, Esteban Felipe

Tipo de recurso:: Trabajo de grado de pregrado

Fecha de publicación:: 2021

Institución:: Universidad Santo Tomás

Repositorio:: Repositorio Institucional USTA

Idioma:: spa

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dc.title.spa.fl_str_mv	Obtaining nettle extracts (Urtica dioica L) by means of hydrocavitation
title	Obtaining nettle extracts (Urtica dioica L) by means of hydrocavitation
spellingShingle	Obtaining nettle extracts (Urtica dioica L) by means of hydrocavitation ß-carotenes hydro-cavitation Urtica dioica L chlorophyll A chlorophyll B Extraction Stinging nettle Cavitation hydro-cavitation Urtica dioica L chlorophyll A chlorophyll B ß-carotenes
title_short	Obtaining nettle extracts (Urtica dioica L) by means of hydrocavitation
title_full	Obtaining nettle extracts (Urtica dioica L) by means of hydrocavitation
title_fullStr	Obtaining nettle extracts (Urtica dioica L) by means of hydrocavitation
title_full_unstemmed	Obtaining nettle extracts (Urtica dioica L) by means of hydrocavitation
title_sort	Obtaining nettle extracts (Urtica dioica L) by means of hydrocavitation
dc.creator.fl_str_mv	Aguirre Dúran, Esteban Felipe
dc.contributor.advisor.none.fl_str_mv	Malagón Romero, Dionisio Humberto
dc.contributor.author.none.fl_str_mv	Aguirre Dúran, Esteban Felipe
dc.contributor.orcid.spa.fl_str_mv	https://orcid.org/0000-0003-2890-2180
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dc.contributor.corporatename.spa.fl_str_mv	Universidad Santo Tomás
dc.subject.keyword.spa.fl_str_mv	ß-carotenes hydro-cavitation Urtica dioica L chlorophyll A chlorophyll B
topic	ß-carotenes hydro-cavitation Urtica dioica L chlorophyll A chlorophyll B Extraction Stinging nettle Cavitation hydro-cavitation Urtica dioica L chlorophyll A chlorophyll B ß-carotenes
dc.subject.lemb.spa.fl_str_mv	Extraction Stinging nettle Cavitation
dc.subject.proposal.spa.fl_str_mv	hydro-cavitation Urtica dioica L chlorophyll A chlorophyll B ß-carotenes
description	La ortiga (Urtica dioica L.) se considera una gran fuente de metabolitos secundarios de interés comercial y la extracción de este tipo de metabolitos es importante para la viabilidad y escalado del proceso. Se han evaluado diferentes alternativas, incluida la extracción Soxhlet y el uso de fluidos supercríticos, principalmente a escala de laboratorio. Como enfoque innovador, la hidrocavitación ha surgido como una alternativa eficiente para extraer principios de plantas a bajas temperaturas y tiempos operativos cortos. Este trabajo presenta la extracción experimental de ß-caroteno de ortiga mediante hidrocavitación. Se utilizó etanol como disolvente a diferentes concentraciones (100%, 90%, 80% y 60%) y dos proporciones p / v soluto / disolvente (1:30 y 2:30). Se determinó la concentración de clorofila A, B, clorofilas totales (A + B), carotenos y ß-carotenos. La mejor concentración de ß-carotenos se obtuvo a razón soluto / disolvente 2:30 con etanol al 100% y un tiempo de operación de 2 minutos, correspondiente a 153,975 mg ß-carotenos / kg, con un consumo de energía de 0,7698 kJ / mg ß -caroteno extraído. Los resultados avalan la viabilidad del uso de la hidrocavitación para la obtención rápida y eficiente de extractos de ortiga a escala piloto y abren la posibilidad para el diseño de procesos a escala industrial.
publishDate	2021
dc.date.accessioned.none.fl_str_mv	2021-07-22T20:03:01Z
dc.date.available.none.fl_str_mv	2021-07-22T20:03:01Z
dc.date.issued.none.fl_str_mv	2021-06-07
dc.type.local.spa.fl_str_mv	Trabajo de grado
dc.type.version.none.fl_str_mv	info:eu-repo/semantics/acceptedVersion
dc.type.category.spa.fl_str_mv	Formación de Recurso Humano para la Ctel: Trabajo de grado de Pregrado
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dc.identifier.citation.spa.fl_str_mv	A. D. E. Felipe, N. Galeano, G. Astrid, and M. Dionisio, “Obtaining nettle extracts ( Urtica dioica L ) by means of hydrocavitation.”retroexcavadoras [Trabajo de Pregrado Ingeniería Mecanica]. Repositorio institucional.
dc.identifier.uri.none.fl_str_mv	http://hdl.handle.net/11634/34996
dc.identifier.reponame.spa.fl_str_mv	reponame:Repositorio Institucional Universidad Santo Tomás
dc.identifier.instname.spa.fl_str_mv	instname:Universidad Santo Tomás
dc.identifier.repourl.spa.fl_str_mv	repourl:https://repository.usta.edu.co
identifier_str_mv	A. D. E. Felipe, N. Galeano, G. Astrid, and M. Dionisio, “Obtaining nettle extracts ( Urtica dioica L ) by means of hydrocavitation.”retroexcavadoras [Trabajo de Pregrado Ingeniería Mecanica]. Repositorio institucional. reponame:Repositorio Institucional Universidad Santo Tomás instname:Universidad Santo Tomás repourl:https://repository.usta.edu.co
url	http://hdl.handle.net/11634/34996
dc.language.iso.spa.fl_str_mv	spa
language	spa
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Upton, “Stinging nettles leaf (Urtica dioica L.): Extraordinary vegetable medicine,” J. Herb. Med., 2013. N. A. Salih, “Effect of nettle (Urtica dioica) extract on gentamicin induced nephrotoxicity in male rabbits,” Asian Pac. J. Trop. Biomed., 2015. Ahmed A. Abdeltawab, “Evaluation of the chemical composition and element analysis of Urtica dioica,” African J. Pharm. Pharmacol., vol. 6, no. 21, pp. 1555–1558, 2012. S. Đurović et al., “Chemical composition of stinging nettle leaves obtained by different analytical approaches,” J. Funct. Foods, vol. 32, pp. 18–26, 2017. S. Polat, “An in vitro evaluation of the effects of Urtica dioica and Fructus Urtica Piluliferae extracts on the crystallization of calcium oxalate,” J. Cryst. Growth, vol. 522, no. April, pp. 92–102, 2019. R. Kargozar, R. Salari, L. Jarahi, M. Yousefi, and S. 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Wielgusz, “The potential of stinging nettle (Urtica dioica L.) as a crop with multiple uses,” Ind. Crops Prod., 2015. C. C. XU, B. WANG, Y. Q. PU, J. S. TAO, and T. ZHANG, “Advances in extraction and analysis of phenolic compounds from plant materials,” Chin. J. Nat. Med., vol. 15, no. 10, pp. 721–731, 2017. U. J. Vajić et al., “Optimization of extraction of stinging nettle leaf phenolic compounds using response surface methodology,” Ind. Crops Prod., 2015. T. T. Shonte, K. G. Duodu, and H. L. de Kock, “Effect of drying methods on chemical composition and antioxidant activity of underutilized stinging nettle leaves,” Heliyon, vol. 6, no. 5, 2020. M. Chaijan, K. Srirattanachot, M. Nisoa, L. Z. Cheong, and W. Panpipat, “Role of antioxidants on physicochemical properties and in vitro bioaccessibility of β-carotene loaded nanoemulsion under thermal and cold plasma discharge accelerated tests,” Food Chem., vol. 339, no. September 2020, p. 128157, 2021. M. A. T. Phan, M. Bucknall, and J. Arcot, “Interactive effects of β-carotene and anthocyanins on cellular uptake, antioxidant activity and anti-inflammatory activity in vitro and ex vivo,” J. Funct. Foods, vol. 45, no. February, pp. 129–137, 2018. C. Ba et al., “Effects of environmental stresses on physiochemical stability of β-carotene in zein-carboxymethyl chitosan-tea polyphenols ternary delivery system,” Food Chem., vol. 311, p. 125878, 2020. N. Y. Lee, Y. Kim, Y. S. Kim, J. H. Shin, L. P. Rubin, and Y. Kim, “β-Carotene exerts anti-colon cancer effects by regulating M2 macrophages and activated fibroblasts,” J. Nutr. Biochem., vol. 82, p. 108402, 2020. U. Blume-Peytavi et al., “Cutaneous lycopene and β-carotene levels measured by resonance Raman spectroscopy: High reliability and sensitivity to oral lactolycopene deprivation and supplementation,” Eur. J. Pharm. Biopharm., vol. 73, no. 1, pp. 187–194, 2009. J. V. Freitas, F. S. G. Praça, M. V. L. B. Bentley, and L. R. 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Laukagalis, “Influence of harvesting time on the chemical composition of wild stinging nettle (Urtica dioica L.),” Plants, vol. 10, no. 4, 2021. M. Hojnik, M. Škerget, and Ž. Knez, “Isolation of chlorophylls from stinging nettle (Urtica dioica L.),” Sep. Purif. Technol., 2007. E. Food et al., “Scientific Opinion on the re-evaluation of chlorophylls (E 140(i)) as food additives,” EFSA J., vol. 13, no. 5, pp. 1–51, 2015. S. M. Nadakatti, J. H. Kim, and S. A. Stern, “Solubility of light gases in poly ( n-butyl methacrylate ) at elevated pressures,” J. Memb. Sci., vol. 108, pp. 279–291, 1995. S. Zeipiņa, I. Alsiņa, and L. Lepse, “Stinging nettle - the source of biologically active compounds as sustainable daily diet supplement,” Res. Rural Dev., vol. 1, pp. 34–38, 2014. D. Mihaylova et al., “Carotenoids, tocopherols, organic acids, carbohydrate and mineral content in different medicinal plant extracts,” Zeitschrift fur Naturforsch. - Sect. C J. 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spelling	Malagón Romero, Dionisio HumbertoAguirre Dúran, Esteban Felipehttps://orcid.org/0000-0003-2890-2180https://scholar.google.es/citations?user=b0ldFjcAAAAJ&hl=eshttp://scienti.colciencias.gov.co:8081/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000167061Universidad Santo Tomás2021-07-22T20:03:01Z2021-07-22T20:03:01Z2021-06-07A. D. E. Felipe, N. Galeano, G. Astrid, and M. Dionisio, “Obtaining nettle extracts ( Urtica dioica L ) by means of hydrocavitation.”retroexcavadoras [Trabajo de Pregrado Ingeniería Mecanica]. Repositorio institucional.http://hdl.handle.net/11634/34996reponame:Repositorio Institucional Universidad Santo Tomásinstname:Universidad Santo Tomásrepourl:https://repository.usta.edu.coLa ortiga (Urtica dioica L.) se considera una gran fuente de metabolitos secundarios de interés comercial y la extracción de este tipo de metabolitos es importante para la viabilidad y escalado del proceso. Se han evaluado diferentes alternativas, incluida la extracción Soxhlet y el uso de fluidos supercríticos, principalmente a escala de laboratorio. Como enfoque innovador, la hidrocavitación ha surgido como una alternativa eficiente para extraer principios de plantas a bajas temperaturas y tiempos operativos cortos. Este trabajo presenta la extracción experimental de ß-caroteno de ortiga mediante hidrocavitación. Se utilizó etanol como disolvente a diferentes concentraciones (100%, 90%, 80% y 60%) y dos proporciones p / v soluto / disolvente (1:30 y 2:30). Se determinó la concentración de clorofila A, B, clorofilas totales (A + B), carotenos y ß-carotenos. La mejor concentración de ß-carotenos se obtuvo a razón soluto / disolvente 2:30 con etanol al 100% y un tiempo de operación de 2 minutos, correspondiente a 153,975 mg ß-carotenos / kg, con un consumo de energía de 0,7698 kJ / mg ß -caroteno extraído. Los resultados avalan la viabilidad del uso de la hidrocavitación para la obtención rápida y eficiente de extractos de ortiga a escala piloto y abren la posibilidad para el diseño de procesos a escala industrial.Abstract- Stinging nettle (Urtica dioica L.) is considered a great source of secondary metabolites of commercial interest and the extraction of this kind of metabolites is important for the process viability and scale-up. Different alternatives have been evaluated, including Soxhlet extraction and the use of super critic fluids, mainly on laboratory scale. As an innovative approach, hydro-cavitation has emerged as an efficient alternative for extracting principles from plants at low temperatures and short operational times. This work presents the experimental extraction of ß-carotene from Stinging nettle employing hydro-cavitation. Ethanol was used as solvent at different concentrations (100%, 90%, 80% and 60%) and two w/v solute/solvent ratio (1:30 and 2:30). The concentration of chlorophyll A, B, total chlorophylls (A+B), carotenes, and ß-carotenes were determined. The best concentration of ß-carotenes was obtained at 2:30 solute/solvent ratio with ethanol at 100% and an operational time of 2 minutes, corresponding to 153.975 mg ß-carotenes/ kg, with a power consumption of 0.7698 kJ/mg ß-carotene extracted. The results support the viability of the use of hydro-cavitation for the rapid and efficient obtaining of Stinging nettle extracts on a pilot scale and open the possibility for the design of processes on an industrial scale.Ingeniero Mecánicohttp://unidadinvestigacion.usta.edu.coPregradoapplication/pdfspaUniversidad Santo TomásPregrado Ingeniería MecánicaFacultad de Ingeniería MecánicaAtribución-NoComercial-SinDerivadas 2.5 Colombiahttp://creativecommons.org/licenses/by-nc-nd/2.5/co/Abierto (Texto Completo)info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Obtaining nettle extracts (Urtica dioica L) by means of hydrocavitationß-caroteneshydro-cavitationUrtica dioica Lchlorophyll Achlorophyll BExtractionStinging nettleCavitationhydro-cavitationUrtica dioica Lchlorophyll Achlorophyll Bß-carotenesTrabajo de gradoinfo:eu-repo/semantics/acceptedVersionFormación de Recurso Humano para la Ctel: Trabajo de grado de Pregradohttp://purl.org/coar/resource_type/c_7a1finfo:eu-repo/semantics/bachelorThesisCRAI-USTA BogotáD. Viboral, E. Retiro, and E. Santuario, “Medicinal plants used in some townships of municipalities in the high plainish,” vol. 33, no. 95, pp. 219–250, 2011.D. Orcic et al., “Quantitative determination of plant phenolics in Urtica dioica extracts by high-performance liquid chromatography coupled with tandem mass spectrometric detection,” Food Chem., vol. 143, pp. 48–53, 2014.C. Proestos, I. S. Boziaris, G. J. E. Nychas, and M. Komaitis, “Analysis of flavonoids and phenolic acids in Greek aromatic plants: Investigation of their antioxidant capacity and antimicrobial activity,” Food Chem., vol. 95, no. 4, pp. 664–671, 2006.R. Dhouibi et al., “Screening of pharmacological uses of Urtica dioica and others benefits,” Prog. Biophys. Mol. Biol., vol. 150, pp. 67–77, 2020.S. Otles and B. Yalcin, “Phenolic compounds analysis of root, stalk, and leaves of nettle,” Sci. World J., vol. 2012, 2012.R. Upton, “Stinging nettles leaf (Urtica dioica L.): Extraordinary vegetable medicine,” J. Herb. 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Biosci., vol. 73, no. 11–12, pp. 439–448, 2018.LICENSElicense.txtlicense.txttext/plain; charset=utf-8807https://repository.usta.edu.co/bitstream/11634/34996/7/license.txtaedeaf396fcd827b537c73d23464fc27MD57open accessORIGINAL2021estebanaguirre.pdf2021estebanaguirre.pdfTrabajo de gradoapplication/pdf332584https://repository.usta.edu.co/bitstream/11634/34996/1/2021estebanaguirre.pdf6b6105c2584b19ae897b02a4750b78bdMD51open accessCARTA CRAI USTA Esteban Felipe Aguirre.pdfCARTA CRAI USTA Esteban Felipe Aguirre.pdfCarta facultadapplication/pdf125623https://repository.usta.edu.co/bitstream/11634/34996/2/CARTA%20CRAI%20USTA%20Esteban%20Felipe%20Aguirre.pdf0ee69a299969db02f1faedd725185ca6MD52metadata only accessCarta_autorizacion_autoarchivo.pdfCarta_autorizacion_autoarchivo.pdfCarta autorizacion auto archivoapplication/pdf285710https://repository.usta.edu.co/bitstream/11634/34996/6/Carta_autorizacion_autoarchivo.pdf68b4aec44768b2deed0c2c6b81aafe45MD56metadata only accessCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8811https://repository.usta.edu.co/bitstream/11634/34996/4/license_rdf217700a34da79ed616c2feb68d4c5e06MD54open accessTHUMBNAIL2021estebanaguirre.pdf.jpg2021estebanaguirre.pdf.jpgIM Thumbnailimage/jpeg9210https://repository.usta.edu.co/bitstream/11634/34996/8/2021estebanaguirre.pdf.jpg860453bcee758577303dab2a5fca3730MD58open accessCARTA CRAI USTA Esteban Felipe Aguirre.pdf.jpgCARTA CRAI USTA Esteban Felipe Aguirre.pdf.jpgIM Thumbnailimage/jpeg6725https://repository.usta.edu.co/bitstream/11634/34996/9/CARTA%20CRAI%20USTA%20Esteban%20Felipe%20Aguirre.pdf.jpg66c2d900ef192e3646fd01cb3a31d34cMD59open accessCarta_autorizacion_autoarchivo.pdf.jpgCarta_autorizacion_autoarchivo.pdf.jpgIM Thumbnailimage/jpeg6777https://repository.usta.edu.co/bitstream/11634/34996/10/Carta_autorizacion_autoarchivo.pdf.jpgc73784ad580c6c944bf67eb148d9722cMD510open access11634/34996oai:repository.usta.edu.co:11634/349962022-10-10 16:04:45.981open accessRepositorio Universidad Santo Tomásrepositorio@usantotomas.edu.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

Obtaining nettle extracts (Urtica dioica L) by means of hydrocavitation

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