Rapid evolution of the Helicobacter pylori AlpA adhesin in a high gastric cancer risk region from Colombia

To be able to survive, Helicobacter pylori must adhere to the gastric epithelial cells of its human host. For this purpose, the bacterium employs an array of adhesins, for example, AlpA. The adhesin AlpA has been proposed as a major adhesin because of its critical role in human stomach colonization....

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Autores:
Gutiérrez Escobar, Andrés Julián
Méndez Callejas, Gina
Acevedo, Orlando
Bravo, Maria Mercedes
Tipo de recurso:
Article of journal
Fecha de publicación:
2018
Institución:
Universidad de Ciencias Aplicadas y Ambientales U.D.C.A
Repositorio:
Repositorio Institucional UDCA
Idioma:
eng
OAI Identifier:
oai:repository.udca.edu.co:11158/2265
Acceso en línea:
https://peerj.com/articles/4846/
Palabra clave:
Helicobacter pylori
Píloro
Neoplasias gástricas
AlpA adhesin
Gene convergence
Helicobacter pylori
Purifying selection
Rapid evolution
Rights
closedAccess
License
Derechos Reservados - Universidad de Ciencias Aplicadas y Ambientales
Description
Summary:To be able to survive, Helicobacter pylori must adhere to the gastric epithelial cells of its human host. For this purpose, the bacterium employs an array of adhesins, for example, AlpA. The adhesin AlpA has been proposed as a major adhesin because of its critical role in human stomach colonization. Therefore, understanding how AlpA evolved could be important for the development of new diagnostic strategies. However, the genetic variation and microevolutionary patterns of alpA have not been described in Colombia. The study aim was to describe the variation patterns and microevolutionary process of alpA in Colombian clinical isolates of H. pylori. The existing polymorphisms, which are deviations from the neutral model of molecular evolution, and the genetic differentiation of the alpA gene from Colombian clinical isolates of H. pylori were determined. The analysis shows that gene conversion and purifying selection have shaped the evolution of three different variants of alpA in Colombia.