Interactome Analysis of Microtubule-targeting Agents Reveals Cytotoxicity Bases in Normal Cells

Cancer causes millions of deaths annually and microtubule-targeting agents (MTAs) are the most commonly-used anti-cancer drugs. However, the high toxicity of MTAs on normal cells raises great concern. Due to the non-selectivity of MTA targets, we analyzed the interaction network in a non-cancerous h...

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Autores:
Gutiérrez Escobar, Andrés Julián
Méndez Callejas, Gina
Tipo de recurso:
Article of journal
Fecha de publicación:
2017
Institución:
Universidad de Ciencias Aplicadas y Ambientales U.D.C.A
Repositorio:
Repositorio Institucional UDCA
Idioma:
eng
OAI Identifier:
oai:repository.udca.edu.co:11158/2143
Acceso en línea:
https://pdf.sciencedirectassets.com/273534/1-s2.0-S1672022917X00077/1-s2.0-S1672022917301717/main.pdf?X-Amz-Security-Token=AgoJb3JpZ2luX2VjEFgaCXVzLWVhc3QtMSJHMEUCIQDV%2B1N%2BNKRKWiKEWx0V262vsZ4fztbB9qafsp0%2FIiYHAAIgBGzMQYi5zp2QOVn2rHMG34OY8gf3qI4s8X0oo59n3ekq2gMIMRACGgwwNTkwMDM1NDY4NjUiDOkXsFRAetvGn%2BCksSq3AzLmqc0u0WkuVA54BTvlGjT5kGK5z5BjYzA4olk2YpVTzqLv27LEK8ICV2%2BfjTBoEVE9vkGSoBryoyfAwWY0PkscwtjVuVIjJd8aL3SrEnxeNuarqCOtQfDGTGS8Wy56eNnmzuPyajb3Axpdk6wMd4PQ%2FgyTOekAbZN2b%2Bbb%2FKbLTDKnKSX2eQCeFJAfn8tz%2FIJ%2F3an1%2FNPcWYb0t2R%2BvWKu6AK%2BSlRxG6M2FoSHuHdbONXSWTtRTuFywfHDkgMQxr%2FQqEsGcFP%2F9%2FT8sTRiKEdqrnF%2Fs3iM5ASVuSa2xGG%2B%2BDv6CW1Ur2EpHeba6yPki9PgDVDFPKeNdQzY4LgGZkwJfXwrMvre4CDNO%2F5q6J%2BdiFOnAdC6Ks9sJR2tjnRqRGHD3zuMhA0palvj5W%2FWoeYlBaVHGJjHj4kOgBoBC04gYliJ%2B00v1giHjTcz3KcjUeibCiF1hmJza7A1i9j5E2XDnEdnCZN3Eug717i6Cf%2FWHjI8HPSVbsjBRidCebsPHr%2Fy9JCkGDL2VycI%2B2ydzupcbmm4UJAkIDhszLWsp8o4kXcPiSmG1E4aN2KLlwOvy0Z39disJnww6O2o7AU6tAGdgFE1KaV%2BvpO2Wx7wVGXkqTFis%2FjN1Bx%2FxbZqmvgUhQAFDXcXb3URKtlr6kKnRMYxm3qYG%2B0c9Wz7Gb3hqV1hoRH6Pycl3x0n0KosaAh0Mc6S%2B6smccDoda6YhOuohCn0gvT5F0Ss%2F%2F5hjsHNxiZ8pHN0P%2FaOe0umusoKkuH8RR8rHie%2FdmtLePSzgRnHA3gTsAnP1VMe2lLjvQGLUpqYgOB9iNugF09QPhkk5FoTjuLGwBI%3D&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Date=20190924T165807Z&X-Amz-SignedHeaders=host&X-Amz-Expires=300&X-Amz-Credential=ASIAQ3PHCVTYQ5FTCZIB%2F20190924%2Fus-east-1%2Fs3%2Faws4_request&X-Amz-Signature=1974310edf90f26bd754e89b3947f07120bf1a6916e7966b4ab132d1caf5e36e&hash=b46e93c8caa03bbef25fffdd1cbd274a3618ab8d1c9981c12cccc29d156e97c3&host=68042c943591013ac2b2430a89b270f6af2c76d8dfd086a07176afe7c76c2c61&pii=S1672022917301717&tid=spdf-f0a6b5af-50c7-4b11-b3d8-0489c53a79ab&sid=0afd8af420e30448121a47726d7031f046eegxrqa&type=client
https://doi.org/10.1016/j.gpb.2017.04.006
Palabra clave:
Neoplasias
Apoptosis
Cinesina
Neoplasm
Apoptosis
Kinesin spindle
Rights
openAccess
License
Derechos Reservados - Universidad de Ciencias Aplicadas y Ambientales