Synthesis and in vitro antiproliferative activity of flavone and 6-hydroxyflavone oxime ethers derivatives

Herein we report the synthesis of a series of O-alkyl oximes of flavone and 6-hydroxyflavone using a simple experimental protocol under solvent free conditions with yields up to 87%. Cytotoxicity of all compounds was evaluated against MDA-MB-231, PC-3, A-549 and MRC-5 cells. IC50 values for two comp...

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Autores:: Díaz, John E.
Martinez, Diana C.
López, Lina V.
Mendez, Gina M.
Vera, Ricardo
Loaiza, Alix E.

Tipo de recurso:: Article of journal

Fecha de publicación:: 2018

Institución:: Universidad de Ciencias Aplicadas y Ambientales U.D.C.A

Repositorio:: Repositorio Institucional UDCA

Idioma:: eng

Description
Summary:	Herein we report the synthesis of a series of O-alkyl oximes of flavone and 6-hydroxyflavone using a simple experimental protocol under solvent free conditions with yields up to 87%. Cytotoxicity of all compounds was evaluated against MDA-MB-231, PC-3, A-549 and MRC-5 cells. IC50 values for two compounds were determined to be in the range 28.7-47.8 μM against all tested cell lines. Oxime ethers derivatives showed IC50 values between 28.7 and 49.5 μM against MDA-MB-231, while the best activity was obtained for 6-hydroxyflavone with an IC50 of 3.4 μM against this cell line. Compounds containing the substituent hydroxyl at the position six of flavone system displayed the best antiproliferative activity over MDA-MB-231 cells, being necessary this group to improve the sensibility on this type of cells. The antiproliferative activity of 6-hydroxyflavone is drastically diminished when the carbonyl group of flavone is changed by an oxime ether.

Synthesis and in vitro antiproliferative activity of flavone and 6-hydroxyflavone oxime ethers derivatives

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