Synthesis and in vitro antiproliferative activity of flavone and 6-hydroxyflavone oxime ethers derivatives

Herein we report the synthesis of a series of O-alkyl oximes of flavone and 6-hydroxyflavone using a simple experimental protocol under solvent free conditions with yields up to 87%. Cytotoxicity of all compounds was evaluated against MDA-MB-231, PC-3, A-549 and MRC-5 cells. IC50 values for two comp...

Full description

Autores:

Díaz, John E.
Martinez, Diana C.
López, Lina V.
Mendez, Gina M.
Vera, Ricardo
Loaiza, Alix E.

Tipo de recurso:

Article of journal

Fecha de publicación:

2018

Institución:

Universidad de Ciencias Aplicadas y Ambientales U.D.C.A

Repositorio:

Repositorio Institucional UDCA

Idioma:

eng

OAI Identifier:

oai:repository.udca.edu.co:11158/2220

Acceso en línea:

http://jbcs.sbq.org.br/imagebank/pdf/2017-0062AR.pdf

Palabra clave:

Cromonas
Éteres
Síntesis química
6-hydroxyflavone
Antiproliferative activity
Flavone
Oxime ethers
Synthesis

Rights

openAccess

License

Derechos Reservados - Universidad de Ciencias Aplicadas y Ambientales