Achyrocline B (3,5 dihydroxy-6,7,8-trimethoxyflavone) synergizes with 5-fluorouracil allowing for dose reduction and reduced off-target toxicity in the treatment of colonic and pancreatic cancers

Surgically unresectable colorectal and pancreatic carcinomas have a high rate of mortality as current therapeutic options are limited. One common chemotherapeutic used to broadly treat both cancers is 5-flurouracil (5-Fu); however, treatment serves only to slow progression of the disease and comes w...

Full description

Autores:

Cartwright, Brian M.
Corso, Jaclyn N.
Lightner, James
Whitted, Crystal
Torrenegra G., Ruben Dario
Koyamangalath, Krishnan
Palau, Victoria E.

Tipo de recurso:

Article of investigation

Fecha de publicación:

2023

Institución:

Universidad de Ciencias Aplicadas y Ambientales U.D.C.A

Repositorio:

Repositorio Institucional UDCA

Idioma:

eng

OAI Identifier:

oai:repository.udca.edu.co:11158/5452

Acceso en línea:

https://repository.udca.edu.co/handle/11158/5452
https://doi.org/10.1016/j.biopha.2023.115546

Palabra clave:

Neoplasias del Colon
Neoplasias Pancreáticas
Flavonas
Antineoplásicos
Fluorouracilo

Rights

closedAccess

License

https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode.es